ENSG00000107854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371627 ENSG00000107854 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS2 protein_coding protein_coding 12.10184 3.338359 22.61641 0.7097404 0.5785468 2.756481 6.951973 1.397382 7.971262 0.1365505 0.1648998 2.503603 0.4875875 0.4532000 0.3531667 -0.1000333 7.690102e-01 1.48186e-19 FALSE TRUE
MSTRG.4372.3 ENSG00000107854 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS2 protein_coding   12.10184 3.338359 22.61641 0.7097404 0.5785468 2.756481 2.347794 0.000000 10.185427 0.0000000 0.4837930 9.993706 0.1149167 0.0000000 0.4515667 0.4515667 1.481860e-19 1.48186e-19 FALSE TRUE
MSTRG.4372.5 ENSG00000107854 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS2 protein_coding   12.10184 3.338359 22.61641 0.7097404 0.5785468 2.756481 2.410183 1.809169 3.653370 0.5783854 0.9159495 1.009892 0.3661042 0.5134667 0.1598000 -0.3536667 1.004853e-02 1.48186e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107854 E001 6.217917 0.0761213710 7.713780e-02 0.2390731339 10 91798426 91798478 53 + 0.614 1.036 1.665
ENSG00000107854 E002 11.742096 0.0747097601 7.168154e-02 0.2281879063 10 91798479 91798723 245 + 0.857 1.259 1.468
ENSG00000107854 E003 3.473444 0.0582320799 4.935658e-01 0.6963193074 10 91798724 91798732 9 + 0.512 0.443 -0.344
ENSG00000107854 E004 26.027564 0.0015450408 2.901615e-02 0.1244000515 10 91798733 91798889 157 + 1.270 1.152 -0.416
ENSG00000107854 E005 1.200009 0.1759906459 9.676372e-01   10 91798890 91798952 63 + 0.259 0.272 0.091
ENSG00000107854 E006 70.529710 0.0053010574 4.514259e-04 0.0052350792 10 91812983 91813207 225 + 1.689 1.546 -0.486
ENSG00000107854 E007 56.120036 0.0018750828 7.145650e-03 0.0453084341 10 91817134 91817229 96 + 1.585 1.502 -0.283
ENSG00000107854 E008 48.711958 0.0007352827 3.596248e-04 0.0043332313 10 91819270 91819306 37 + 1.536 1.362 -0.599
ENSG00000107854 E009 65.155810 0.0007120162 2.328208e-03 0.0192369133 10 91819482 91819557 76 + 1.649 1.559 -0.308
ENSG00000107854 E010 81.438280 0.0098039584 4.760458e-03 0.0333320382 10 91819939 91820033 95 + 1.744 1.638 -0.360
ENSG00000107854 E011 66.352578 0.0199895473 4.625251e-02 0.1706661876 10 91822296 91822362 67 + 1.654 1.572 -0.278
ENSG00000107854 E012 96.358983 0.0203155424 2.444146e-03 0.0199729622 10 91827017 91827203 187 + 1.822 1.654 -0.567
ENSG00000107854 E013 77.018550 0.0149837045 5.334745e-04 0.0059801330 10 91828285 91828406 122 + 1.729 1.535 -0.661
ENSG00000107854 E014 72.724119 0.0164088722 1.121967e-04 0.0016448189 10 91830923 91831014 92 + 1.710 1.461 -0.848
ENSG00000107854 E015 77.123023 0.0016499374 4.928757e-05 0.0008214269 10 91831103 91831181 79 + 1.730 1.579 -0.515
ENSG00000107854 E016 122.552739 0.0011131339 2.263132e-03 0.0188158133 10 91833853 91834024 172 + 1.914 1.880 -0.116
ENSG00000107854 E017 4.084975 0.0065868465 5.042589e-01 0.7037624700 10 91836796 91836884 89 + 0.527 0.733 0.897
ENSG00000107854 E018 89.738495 0.0236726582 2.273211e-01 0.4621869222 10 91836919 91836998 80 + 1.775 1.772 -0.010
ENSG00000107854 E019 105.838687 0.0192878455 2.022828e-01 0.4325012672 10 91840561 91840706 146 + 1.843 1.858 0.051
ENSG00000107854 E020 99.589712 0.0131812996 1.930943e-02 0.0935390153 10 91841283 91841448 166 + 1.826 1.764 -0.209
ENSG00000107854 E021 110.247219 0.0037527288 6.420026e-05 0.0010314740 10 91842172 91842391 220 + 1.876 1.752 -0.419
ENSG00000107854 E022 77.091119 0.0123206103 3.177578e-03 0.0244739364 10 91844919 91845028 110 + 1.724 1.597 -0.431
ENSG00000107854 E023 115.044945 0.0084185609 5.325183e-02 0.1873465241 10 91845752 91845940 189 + 1.882 1.874 -0.027
ENSG00000107854 E024 150.154844 0.0118038847 3.601927e-01 0.5958696783 10 91848383 91848635 253 + 1.988 2.046 0.194
ENSG00000107854 E025 95.884734 0.0192059094 1.929426e-01 0.4207158373 10 91849512 91849594 83 + 1.801 1.814 0.045
ENSG00000107854 E026 121.497082 0.0140287055 3.209411e-01 0.5605362409 10 91851216 91851336 121 + 1.897 1.949 0.172
ENSG00000107854 E027 112.159222 0.0108605202 6.053244e-01 0.7737401525 10 91855029 91855126 98 + 1.858 1.951 0.311
ENSG00000107854 E028 106.262433 0.0099121823 9.942025e-01 0.9986814369 10 91855614 91855688 75 + 1.831 1.958 0.429
ENSG00000107854 E029 103.269647 0.0033421227 2.729133e-01 0.5127364513 10 91857425 91857530 106 + 1.809 1.986 0.595
ENSG00000107854 E030 110.494345 0.0004329047 5.856049e-02 0.1995689039 10 91859462 91859648 187 + 1.837 2.035 0.665
ENSG00000107854 E031 98.462549 0.0159663239 1.345917e-03 0.0125036970 10 91861999 91862155 157 + 1.759 2.093 1.125
ENSG00000107854 E032 580.882375 1.5131013542 3.182270e-01 0.5581447445 10 91862937 91865475 2539 + 2.497 2.934 1.453