ENSG00000107821

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370200 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding protein_coding 5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.9265270 0.9004811 0.56343999 0.1264002 0.09525808 -0.66698659 0.18364167 0.12510000 0.24110000 0.11600000 4.812257e-01 1.044101e-07 FALSE TRUE
ENST00000465807 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding processed_transcript 5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.8704392 1.7708830 0.00000000 0.4330912 0.00000000 -7.47644890 0.15082917 0.23123333 0.00000000 -0.23123333 1.044101e-07 1.044101e-07 FALSE FALSE
ENST00000477267 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding processed_transcript 5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 1.4420955 1.6775107 1.12851406 0.2382012 0.24163245 -0.56774455 0.26840833 0.23506667 0.46156667 0.22650000 2.656373e-01 1.044101e-07 FALSE FALSE
ENST00000477979 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding processed_transcript 5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.6838143 1.0691630 0.20155590 0.1343000 0.10786185 -2.35080197 0.13583333 0.14276667 0.08100000 -0.06176667 7.088010e-01 1.044101e-07 FALSE TRUE
MSTRG.4521.1 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding   5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.4508833 0.4172830 0.41246400 0.2921859 0.09979581 -0.01636348 0.08754583 0.06470000 0.17813333 0.11343333 4.198935e-01 1.044101e-07 FALSE TRUE
MSTRG.4521.2 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding   5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.3876200 0.5578743 0.00000000 0.3390014 0.00000000 -5.82749982 0.08285417 0.06973333 0.00000000 -0.06973333 5.299106e-01 1.044101e-07 FALSE TRUE
MSTRG.4521.3 ENSG00000107821 HEK293_OSMI2_6hA HEK293_TMG_6hB KAZALD1 protein_coding   5.244385 7.468829 2.400934 0.6854316 0.1526094 -1.63322 0.4192570 0.7940776 0.09496033 0.3987949 0.04752635 -2.93749054 0.08257500 0.09800000 0.03823333 -0.05976667 9.208391e-01 1.044101e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107821 E001 5.976840 0.0046330953 0.03022086 0.12799771 10 101061818 101061835 18 + 0.456 0.828 1.626
ENSG00000107821 E002 8.648261 0.0034707690 0.01807533 0.08929634 10 101061836 101061915 80 + 0.611 0.966 1.418
ENSG00000107821 E003 8.460006 0.0040950782 0.46146980 0.67418164 10 101061916 101061988 73 + 0.817 0.916 0.384
ENSG00000107821 E004 6.257996 0.0152887628 0.52832044 0.72086913 10 101061989 101062003 15 + 0.855 0.759 -0.377
ENSG00000107821 E005 10.329553 0.0048126486 0.98167355 0.99261539 10 101062004 101062072 69 + 0.984 0.982 -0.009
ENSG00000107821 E006 12.495377 0.0243209498 0.99708408 1.00000000 10 101062073 101062115 43 + 1.059 1.060 0.004
ENSG00000107821 E007 23.293213 0.0515704098 0.24328004 0.48032993 10 101062542 101062985 444 + 1.179 1.335 0.550
ENSG00000107821 E008 14.794577 0.0772341307 0.90058499 0.95216337 10 101062986 101063077 92 + 1.107 1.117 0.037
ENSG00000107821 E009 12.931864 0.0047805280 0.84328901 0.92128241 10 101063078 101063103 26 + 1.037 1.060 0.084
ENSG00000107821 E010 5.382218 0.0823060224 0.19612262 0.42468768 10 101064206 101064260 55 + 0.891 0.675 -0.862
ENSG00000107821 E011 32.450773 0.0013958273 0.23817345 0.47450872 10 101064261 101064421 161 + 1.504 1.425 -0.271
ENSG00000107821 E012 34.844127 0.0016418165 0.53616695 0.72642871 10 101064501 101064648 148 + 1.504 1.464 -0.136
ENSG00000107821 E013 24.094111 0.0016883037 0.65213762 0.80483048 10 101064826 101064920 95 + 1.291 1.330 0.137
ENSG00000107821 E014 10.715925 0.0031239539 0.97144897 0.98759259 10 101064921 101064943 23 + 0.984 0.990 0.020
ENSG00000107821 E015 57.285185 0.0009313602 0.01431350 0.07556928 10 101064944 101066298 1355 + 1.771 1.651 -0.407
ENSG00000107821 E016 9.239157 0.0154538464 0.15479802 0.36910146 10 101066299 101066394 96 + 1.062 0.888 -0.648
ENSG00000107821 E017 12.248279 0.0040322553 0.75462921 0.86947288 10 101066395 101066548 154 + 1.061 1.026 -0.125
ENSG00000107821 E018 11.983904 0.0517319606 0.32991743 0.56889443 10 101066549 101067059 511 + 1.141 0.992 -0.542
ENSG00000107821 E019 83.334988 0.0009824561 0.01559938 0.08035959 10 101067248 101068131 884 + 1.753 1.863 0.371