ENSG00000107719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263563 ENSG00000107719 HEK293_OSMI2_6hA HEK293_TMG_6hB PALD1 protein_coding protein_coding 18.8458 30.98795 10.56827 5.10907 0.1319373 -1.551069 5.9584264 10.975650 0.2164154 4.1414888 0.2164154 -5.6005044 0.33288333 0.33603333 0.02000000 -0.31603333 0.0377840 0.03266436 FALSE TRUE
MSTRG.4120.11 ENSG00000107719 HEK293_OSMI2_6hA HEK293_TMG_6hB PALD1 protein_coding   18.8458 30.98795 10.56827 5.10907 0.1319373 -1.551069 9.3894580 13.439462 7.9146960 1.4495591 0.6813169 -0.7631210 0.47164167 0.45496667 0.74780000 0.29283333 0.1092022 0.03266436 FALSE TRUE
MSTRG.4120.4 ENSG00000107719 HEK293_OSMI2_6hA HEK293_TMG_6hB PALD1 protein_coding   18.8458 30.98795 10.56827 5.10907 0.1319373 -1.551069 1.2354011 2.649078 0.6371842 1.0784397 0.0829994 -2.0386776 0.05430417 0.08550000 0.06050000 -0.02500000 0.9033210 0.03266436 FALSE TRUE
MSTRG.4120.5 ENSG00000107719 HEK293_OSMI2_6hA HEK293_TMG_6hB PALD1 protein_coding   18.8458 30.98795 10.56827 5.10907 0.1319373 -1.551069 0.8284069 1.576414 0.8352207 0.2910868 0.2165175 -0.9083698 0.05203333 0.05063333 0.07956667 0.02893333 0.7272323 0.03266436 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107719 E001 0.1308682 0.0326491905 1.0000000000   10 70478767 70478778 12 + 0.000 0.068 7.721
ENSG00000107719 E002 2.0045285 0.6740196397 0.3017541159 0.542291575 10 70478779 70478795 17 + 0.000 0.505 12.170
ENSG00000107719 E003 6.6592826 0.2021970033 0.0235819423 0.107796939 10 70478796 70478815 20 + 0.207 0.902 3.519
ENSG00000107719 E004 7.7909580 0.2071921333 0.0140411748 0.074502107 10 70478816 70478819 4 + 0.207 0.961 3.739
ENSG00000107719 E005 11.2296642 0.1254225601 0.0040218291 0.029286870 10 70478820 70478828 9 + 0.348 1.101 3.245
ENSG00000107719 E006 11.7356409 0.1076399375 0.0019790218 0.016927744 10 70478829 70478829 1 + 0.348 1.120 3.311
ENSG00000107719 E007 19.9077373 0.0333057827 0.0005792202 0.006392728 10 70478830 70478866 37 + 0.772 1.320 2.019
ENSG00000107719 E008 56.6175956 0.0278336613 0.0052275061 0.035816621 10 70478867 70479059 193 + 1.422 1.728 1.045
ENSG00000107719 E009 4.7835604 0.0055703634 0.0592288276 0.201074217 10 70479060 70479170 111 + 0.889 0.625 -1.068
ENSG00000107719 E010 0.9867257 0.2198829896 0.2277127338   10 70482963 70482992 30 + 0.452 0.217 -1.498
ENSG00000107719 E011 0.6661073 0.3639111230 0.8829369844   10 70482993 70482998 6 + 0.206 0.213 0.066
ENSG00000107719 E012 1.2812224 0.4879782066 0.2202409383   10 70482999 70483007 9 + 0.537 0.249 -1.657
ENSG00000107719 E013 2.5654613 0.0095274865 0.0207297689 0.098428930 10 70483008 70483064 57 + 0.771 0.402 -1.687
ENSG00000107719 E014 155.2578111 0.0003071193 0.0069675068 0.044489506 10 70525923 70526136 214 + 2.176 2.096 -0.268
ENSG00000107719 E015 141.6201006 0.0004188807 0.0486937010 0.176575666 10 70529229 70529331 103 + 2.119 2.058 -0.207
ENSG00000107719 E016 194.1027347 0.0004051942 0.2119385488 0.444028059 10 70529889 70530068 180 + 2.231 2.202 -0.099
ENSG00000107719 E017 183.8535926 0.0002483807 0.0008753763 0.008893750 10 70531290 70531454 165 + 2.256 2.164 -0.306
ENSG00000107719 E018 141.8682424 0.0004184638 0.0137515616 0.073363281 10 70532621 70532714 94 + 2.135 2.058 -0.259
ENSG00000107719 E019 102.7691275 0.0004012058 0.0701631035 0.225110214 10 70532715 70532781 67 + 1.988 1.923 -0.217
ENSG00000107719 E020 99.1406817 0.0011028167 0.3376162867 0.576005492 10 70532995 70533070 76 + 1.945 1.912 -0.112
ENSG00000107719 E021 159.3441607 0.0003260936 0.1415438859 0.349792741 10 70533922 70534073 152 + 2.154 2.114 -0.135
ENSG00000107719 E022 136.6163969 0.0005910124 0.3980507023 0.626785268 10 70534425 70534524 100 + 2.075 2.052 -0.075
ENSG00000107719 E023 129.5331224 0.0127598801 0.7347460235 0.857136678 10 70534739 70534843 105 + 2.048 2.026 -0.072
ENSG00000107719 E024 114.1028038 0.0018576684 0.7578895263 0.871315082 10 70537811 70537906 96 + 1.965 1.985 0.066
ENSG00000107719 E025 79.8351242 0.0108904427 0.3968123910 0.625798600 10 70538280 70538302 23 + 1.870 1.809 -0.206
ENSG00000107719 E026 138.5064631 0.0004861626 0.6164699034 0.781370753 10 70538303 70538408 106 + 2.042 2.068 0.088
ENSG00000107719 E027 156.8767509 0.0005159329 0.0095831350 0.056326333 10 70538892 70539008 117 + 2.037 2.139 0.341
ENSG00000107719 E028 135.0784212 0.0030476349 0.0602758303 0.203442757 10 70539092 70539154 63 + 1.980 2.067 0.294
ENSG00000107719 E029 140.7369256 0.0029966988 0.6159423314 0.780967123 10 70539155 70539247 93 + 2.047 2.071 0.081
ENSG00000107719 E030 126.8027054 0.0084811296 0.8830114641 0.942832704 10 70539580 70539675 96 + 2.028 2.020 -0.027
ENSG00000107719 E031 137.2964913 0.0045170925 0.6490249671 0.802874156 10 70539676 70539762 87 + 2.038 2.062 0.082
ENSG00000107719 E032 189.0807929 0.0002566271 0.6916715417 0.830138148 10 70541102 70541242 141 + 2.200 2.197 -0.013
ENSG00000107719 E033 159.5849026 0.0003250572 0.0312117237 0.130953369 10 70541463 70541534 72 + 2.174 2.113 -0.206
ENSG00000107719 E034 174.2326394 0.0003770786 0.4533019074 0.668203825 10 70547306 70547446 141 + 2.175 2.159 -0.052
ENSG00000107719 E035 20.7700403 0.0338646629 0.5998368085 0.770105406 10 70551037 70551361 325 + 1.304 1.246 -0.206
ENSG00000107719 E036 169.9853771 0.0003124500 0.4541041624 0.668799275 10 70564364 70564519 156 + 2.164 2.148 -0.052
ENSG00000107719 E037 1106.3582270 0.0003584006 0.0002048971 0.002728583 10 70566581 70568450 1870 + 2.916 2.972 0.184