ENSG00000107669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000224652 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding protein_coding 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 0.84039962 0.27108039 2.550398 0.27108039 0.8867634 3.1873132 0.11840833 0.08443333 0.1932000 0.10876667 0.5024252669 0.0001279561 FALSE TRUE
ENST00000369043 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding protein_coding 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 2.69917794 0.67538085 4.130007 0.34220231 0.3416158 2.5946552 0.26686250 0.22043333 0.3156667 0.09523333 0.8345321281 0.0001279561 FALSE TRUE
ENST00000686786 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding nonsense_mediated_decay 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 0.06951185 0.17577687 0.000000 0.10485066 0.0000000 -4.2154990 0.02599583 0.08106667 0.0000000 -0.08106667 0.0935507589 0.0001279561 FALSE TRUE
ENST00000687458 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding protein_coding 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 0.32982922 0.27052370 0.146056 0.04500685 0.0317032 -0.8460588 0.08200417 0.10323333 0.0113000 -0.09193333 0.0001279561 0.0001279561 FALSE TRUE
ENST00000689455 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding nonsense_mediated_decay 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 1.14704117 0.05060925 1.289477 0.05060925 0.6499235 4.4222494 0.08882500 0.02676667 0.1000667 0.07330000 0.7789738465 0.0001279561 FALSE TRUE
ENST00000690355 ENSG00000107669 HEK293_OSMI2_6hA HEK293_TMG_6hB ATE1 protein_coding protein_coding 8.129353 2.684372 13.06309 0.4040011 0.3110057 2.278579 0.81920733 0.34478185 1.371840 0.09111567 0.7112270 1.9615862 0.11196667 0.14620000 0.1068000 -0.03940000 0.9054494227 0.0001279561 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107669 E001 0.0000000       10 121709393 121709483 91 -      
ENSG00000107669 E002 0.9888187 0.0154719898 8.214006e-01   10 121740424 121740431 8 - 0.262 0.212 -0.390
ENSG00000107669 E003 0.9888187 0.0154719898 8.214006e-01   10 121740432 121740432 1 - 0.262 0.212 -0.390
ENSG00000107669 E004 6.8607874 0.0045738952 4.478234e-01 0.6641040136 10 121740433 121740474 42 - 0.842 0.733 -0.435
ENSG00000107669 E005 22.4397986 0.0015977575 7.165751e-01 0.8459837069 10 121740475 121740546 72 - 1.279 1.312 0.116
ENSG00000107669 E006 146.1149429 0.0005201891 5.365549e-01 0.7267249863 10 121740547 121741489 943 - 2.076 2.099 0.079
ENSG00000107669 E007 78.9246488 0.0157292146 2.430100e-01 0.4800079487 10 121741490 121741853 364 - 1.794 1.875 0.273
ENSG00000107669 E008 155.6911833 0.0004030523 5.236652e-01 0.7175741255 10 121741854 121742940 1087 - 2.104 2.127 0.077
ENSG00000107669 E009 58.8952881 0.0006875293 2.995776e-01 0.5400015382 10 121742941 121743183 243 - 1.704 1.648 -0.191
ENSG00000107669 E010 71.2008217 0.0022088939 2.333799e-01 0.4690161019 10 121743184 121743417 234 - 1.789 1.726 -0.214
ENSG00000107669 E011 32.6991430 0.0011572147 7.630796e-01 0.8744810614 10 121743418 121743468 51 - 1.444 1.467 0.081
ENSG00000107669 E012 22.9233055 0.0018677509 3.463760e-01 0.5839399156 10 121743469 121743472 4 - 1.283 1.362 0.278
ENSG00000107669 E013 31.9124250 0.0053985326 6.926521e-01 0.8308019421 10 121743473 121743550 78 - 1.429 1.458 0.100
ENSG00000107669 E014 15.0045848 0.0192420443 2.240281e-01 0.4582345297 10 121743551 121743575 25 - 1.155 0.993 -0.589
ENSG00000107669 E015 13.5149509 0.0219550500 2.890036e-01 0.5295462794 10 121743576 121743576 1 - 1.113 0.964 -0.546
ENSG00000107669 E016 30.5615654 0.0015249279 7.368558e-01 0.8585283207 10 121743577 121743658 82 - 1.422 1.397 -0.088
ENSG00000107669 E017 32.0423743 0.0014162925 3.157242e-01 0.5557284088 10 121743659 121743728 70 - 1.420 1.494 0.255
ENSG00000107669 E018 32.1007337 0.0013200099 8.033721e-01 0.8982878925 10 121743729 121743791 63 - 1.444 1.428 -0.055
ENSG00000107669 E019 38.3108846 0.0080437531 7.638245e-02 0.2374818600 10 121743792 121743858 67 - 1.536 1.395 -0.486
ENSG00000107669 E020 2.1424114 0.0104859764 2.167309e-05 0.0004089998 10 121763476 121763897 422 - 0.175 0.863 3.668
ENSG00000107669 E021 3.4469768 0.0496358724 1.008582e-02 0.0585233755 10 121763898 121764479 582 - 0.424 0.869 1.949
ENSG00000107669 E022 0.9217543 0.0161219275 4.887520e-01   10 121782494 121782699 206 - 0.221 0.353 0.926
ENSG00000107669 E023 0.0000000       10 121789439 121789551 113 -      
ENSG00000107669 E024 0.6190593 0.0220428728 8.353587e-01   10 121789552 121790168 617 - 0.175 0.212 0.348
ENSG00000107669 E025 45.4376255 0.0017452234 7.783616e-02 0.2404870560 10 121790169 121790289 121 - 1.603 1.485 -0.401
ENSG00000107669 E026 0.0000000       10 121790290 121790532 243 -      
ENSG00000107669 E027 48.4451865 0.0052241570 3.987913e-01 0.6272709722 10 121836718 121836817 100 - 1.620 1.559 -0.208
ENSG00000107669 E028 0.1779838 0.0355928124 1.000000e+00   10 121837340 121837376 37 - 0.067 0.000 -8.694
ENSG00000107669 E029 67.6682469 0.0007729442 5.338756e-02 0.1876448319 10 121841082 121841259 178 - 1.770 1.666 -0.352
ENSG00000107669 E030 26.6426351 0.0017804173 4.576273e-01 0.6715233216 10 121841260 121841263 4 - 1.373 1.312 -0.213
ENSG00000107669 E031 0.0000000       10 121841621 121841667 47 -      
ENSG00000107669 E032 0.0000000       10 121841874 121841971 98 -      
ENSG00000107669 E033 0.0000000       10 121845148 121845219 72 -      
ENSG00000107669 E034 1.3110299 0.2601991314 7.647517e-01   10 121851295 121851412 118 - 0.300 0.357 0.356
ENSG00000107669 E035 1.0348663 0.5032154905 2.983562e-02   10 121857059 121857606 548 - 0.065 0.634 4.343
ENSG00000107669 E036 34.8235947 0.0115914579 3.892710e-01 0.6199353975 10 121870006 121870038 33 - 1.489 1.407 -0.283
ENSG00000107669 E037 0.4514866 0.0217681645 5.974028e-01   10 121878333 121878583 251 - 0.124 0.212 0.928
ENSG00000107669 E038 5.4187784 0.0055121843 2.930785e-03 0.0229848886 10 121888998 121890100 1103 - 0.617 1.019 1.588
ENSG00000107669 E039 39.3496860 0.0011172272 8.484322e-02 0.2543279248 10 121898841 121898969 129 - 1.497 1.609 0.382
ENSG00000107669 E040 0.3559677 0.5083730757 1.000000e+00   10 121899313 121899865 553 - 0.127 0.000 -8.764
ENSG00000107669 E041 31.3689361 0.0013051161 1.517415e-01 0.3648581504 10 121899866 121899994 129 - 1.449 1.338 -0.384
ENSG00000107669 E042 61.3557314 0.0007765656 3.196840e-01 0.5594338931 10 121902391 121902504 114 - 1.725 1.671 -0.180
ENSG00000107669 E043 57.6838038 0.0007064043 9.086919e-02 0.2652905572 10 121902505 121902620 116 - 1.705 1.609 -0.327
ENSG00000107669 E044 1.2437282 0.0140254077 5.542518e-01   10 121910413 121910905 493 - 0.334 0.212 -0.875
ENSG00000107669 E045 82.7821969 0.0005059592 7.341460e-02 0.2316373127 10 121910906 121911112 207 - 1.855 1.770 -0.285
ENSG00000107669 E046 42.9392768 0.0008612708 6.474178e-01 0.8017678467 10 121911113 121911151 39 - 1.551 1.581 0.105
ENSG00000107669 E047 49.1450767 0.0009763959 1.661114e-01 0.3853183786 10 121913790 121913893 104 - 1.600 1.683 0.281
ENSG00000107669 E048 1.0399283 0.2281014602 1.549502e-01   10 121917529 121922348 4820 - 0.178 0.463 1.908
ENSG00000107669 E049 40.9500381 0.0009554156 8.713266e-02 0.2585057825 10 121922349 121922411 63 - 1.513 1.622 0.373
ENSG00000107669 E050 42.8841493 0.0008560648 1.137747e-01 0.3054269506 10 121924266 121924329 64 - 1.536 1.635 0.337
ENSG00000107669 E051 3.6351677 0.0069941530 6.753017e-01 0.8197468633 10 121926423 121926733 311 - 0.617 0.546 -0.321
ENSG00000107669 E052 2.3821259 0.0273895652 9.473847e-01 0.9759877629 10 121926734 121926995 262 - 0.451 0.462 0.058
ENSG00000107669 E053 1.3650427 0.0864351392 4.236091e-01   10 121926996 121927137 142 - 0.298 0.458 0.922
ENSG00000107669 E054 2.3508407 0.0088626637 9.773450e-02 0.2777901380 10 121927138 121927317 180 - 0.396 0.679 1.344
ENSG00000107669 E055 2.0940937 0.0163947745 4.074281e-01 0.6340263508 10 121927503 121927843 341 - 0.396 0.546 0.760
ENSG00000107669 E056 30.0367826 0.0014099999 2.756460e-01 0.5157445025 10 121927844 121928075 232 - 1.394 1.476 0.282
ENSG00000107669 E057 3.9223741 0.0074062322 1.094202e-02 0.0621238109 10 121928347 121928801 455 - 0.520 0.899 1.583