ENSG00000107651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369075 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding protein_coding 26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 4.884782 3.242801 7.014417 0.7718834 0.04083376 1.1106958 0.21057500 0.2537333 0.1575667 -0.09616667 7.941542e-02 1.739093e-16 FALSE TRUE
ENST00000442952 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding protein_coding 26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 1.531773 2.202996 1.331333 0.1199421 0.13278900 -0.7223331 0.09880000 0.1941333 0.0302000 -0.16393333 5.117190e-05 1.739093e-16 FALSE TRUE
ENST00000446561 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding protein_coding 26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 2.748723 0.000000 6.030469 0.0000000 0.99939727 9.2385168 0.06775833 0.0000000 0.1325667 0.13256667 1.739093e-16 1.739093e-16 FALSE FALSE
ENST00000475542 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding processed_transcript 26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 4.395611 1.244135 8.108098 1.2441346 0.76548428 2.6944496 0.15501250 0.0677000 0.1797333 0.11203333 3.008173e-01 1.739093e-16 FALSE TRUE
MSTRG.4735.4 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding   26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 6.500339 2.801636 12.459475 0.6647057 1.49064282 2.1489192 0.19745000 0.2297667 0.2751333 0.04536667 8.211819e-01 1.739093e-16 TRUE TRUE
MSTRG.4735.7 ENSG00000107651 HEK293_OSMI2_6hA HEK293_TMG_6hB SEC23IP protein_coding   26.62709 12.88828 44.95037 3.305376 2.922445 1.801475 4.690166 2.595542 7.253387 1.1400815 0.31614384 1.4790589 0.20028750 0.1797000 0.1636667 -0.01603333 9.745710e-01 1.739093e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107651 E001 1.0185584 0.0153787590 8.261500e-01   10 119892683 119892704 22 + 0.261 0.304 0.295
ENSG00000107651 E002 3.6888003 0.0072716018 4.330862e-01 6.535205e-01 10 119892705 119892717 13 + 0.673 0.547 -0.553
ENSG00000107651 E003 5.3036929 0.0054946998 5.393653e-01 7.285474e-01 10 119892718 119892725 8 + 0.789 0.703 -0.349
ENSG00000107651 E004 6.3079120 0.0047333581 4.013793e-01 6.294716e-01 10 119892726 119892729 4 + 0.856 0.744 -0.444
ENSG00000107651 E005 6.3079120 0.0047333581 4.013793e-01 6.294716e-01 10 119892730 119892730 1 + 0.856 0.744 -0.444
ENSG00000107651 E006 12.8481512 0.0024772742 5.623509e-02 1.941855e-01 10 119892731 119892739 9 + 1.158 0.958 -0.730
ENSG00000107651 E007 24.1357026 0.0232939326 9.828537e-01 9.932055e-01 10 119892740 119892744 5 + 1.366 1.355 -0.039
ENSG00000107651 E008 139.4006333 0.0054218982 2.919642e-01 5.326380e-01 10 119892745 119892945 201 + 2.124 2.075 -0.165
ENSG00000107651 E009 11.1806673 0.0049427900 7.819890e-01 8.858170e-01 10 119898244 119898426 183 + 1.029 1.065 0.131
ENSG00000107651 E010 131.4026527 0.0003946685 5.958525e-03 3.952861e-02 10 119898427 119898518 92 + 2.110 2.019 -0.304
ENSG00000107651 E011 185.9096641 0.0013097141 3.065049e-02 1.293014e-01 10 119898519 119898740 222 + 2.253 2.186 -0.222
ENSG00000107651 E012 166.0294013 0.0051528532 7.354651e-01 8.575923e-01 10 119898741 119898959 219 + 2.188 2.181 -0.023
ENSG00000107651 E013 56.6136139 0.0134431761 9.260419e-01 9.651307e-01 10 119902799 119902806 8 + 1.720 1.741 0.072
ENSG00000107651 E014 104.3778243 0.0016157181 9.563357e-01 9.800665e-01 10 119902807 119902900 94 + 1.983 1.988 0.016
ENSG00000107651 E015 136.9229978 0.0011764625 5.481612e-01 7.350306e-01 10 119902901 119903009 109 + 2.106 2.089 -0.057
ENSG00000107651 E016 163.1926878 0.0010599744 7.900891e-01 8.905966e-01 10 119904084 119904193 110 + 2.177 2.173 -0.016
ENSG00000107651 E017 159.8621024 0.0007514517 4.529641e-01 6.678993e-01 10 119904194 119904277 84 + 2.172 2.152 -0.069
ENSG00000107651 E018 16.6521890 0.0179561287 3.894425e-11 3.000739e-09 10 119904278 119904662 385 + 0.881 1.561 2.424
ENSG00000107651 E019 144.5246315 0.0047270182 6.467708e-02 2.131637e-01 10 119909041 119909130 90 + 2.145 2.058 -0.292
ENSG00000107651 E020 186.7474114 0.0022147682 6.174975e-02 2.067655e-01 10 119912044 119912164 121 + 2.251 2.185 -0.220
ENSG00000107651 E021 0.6622309 0.1932714047 2.673890e-01   10 119914500 119914729 230 + 0.263 0.000 -11.033
ENSG00000107651 E022 157.6135893 0.0004837976 3.015208e-02 1.277925e-01 10 119914730 119914819 90 + 2.179 2.115 -0.214
ENSG00000107651 E023 178.5001010 0.0002476958 1.236160e-01 3.214486e-01 10 119915748 119915889 142 + 2.227 2.187 -0.131
ENSG00000107651 E024 172.7437134 0.0009099462 9.233167e-01 9.639547e-01 10 119917836 119918044 209 + 2.198 2.206 0.027
ENSG00000107651 E025 142.0533192 0.0069416674 5.928680e-01 7.655523e-01 10 119918393 119918511 119 + 2.104 2.135 0.101
ENSG00000107651 E026 191.0645808 0.0002668796 7.817051e-01 8.856460e-01 10 119919444 119919596 153 + 2.240 2.254 0.046
ENSG00000107651 E027 165.0422163 0.0003033517 5.013776e-01 7.017907e-01 10 119920889 119920984 96 + 2.185 2.171 -0.047
ENSG00000107651 E028 208.1890322 0.0094533940 7.955887e-01 8.937772e-01 10 119926036 119926227 192 + 2.277 2.288 0.034
ENSG00000107651 E029 93.5798749 0.0132183938 4.932147e-01 6.961139e-01 10 119929607 119929644 38 + 1.942 1.921 -0.070
ENSG00000107651 E030 170.3078933 0.0015085184 2.042776e-01 4.350027e-01 10 119929645 119929762 118 + 2.203 2.167 -0.120
ENSG00000107651 E031 164.4584439 0.0003581831 3.186652e-01 5.584679e-01 10 119930329 119930431 103 + 2.185 2.160 -0.083
ENSG00000107651 E032 226.1156737 0.0002678225 7.164712e-02 2.281217e-01 10 119932133 119932318 186 + 2.328 2.287 -0.138
ENSG00000107651 E033 79.6220469 0.0013298379 3.818460e-01 6.137777e-01 10 119933005 119933007 3 + 1.880 1.846 -0.116
ENSG00000107651 E034 194.5718947 0.0011056323 6.594286e-01 8.096340e-01 10 119933008 119933167 160 + 2.245 2.266 0.068
ENSG00000107651 E035 161.4706688 0.0003519407 3.563993e-03 2.672631e-02 10 119933686 119933785 100 + 2.140 2.234 0.313
ENSG00000107651 E036 78.2705815 0.0044637692 1.247830e-01 3.233950e-01 10 119933786 119933787 2 + 1.827 1.913 0.289
ENSG00000107651 E037 278.2261510 0.0002019354 1.147710e-04 1.676048e-03 10 119940586 119940792 207 + 2.375 2.469 0.312
ENSG00000107651 E038 244.1481041 0.0021314908 8.860481e-03 5.319264e-02 10 119940793 119941111 319 + 2.320 2.412 0.308
ENSG00000107651 E039 143.3843739 0.0019816726 2.781689e-01 5.182975e-01 10 119941112 119941180 69 + 2.130 2.094 -0.121
ENSG00000107651 E040 178.8589040 0.0003595784 1.494334e-01 3.614474e-01 10 119941181 119941308 128 + 2.226 2.189 -0.123
ENSG00000107651 E041 226.1589567 0.0129683024 8.873226e-02 2.614609e-01 10 119941309 119942173 865 + 2.274 2.400 0.422
ENSG00000107651 E042 10.6275882 0.0172270195 1.252341e-01 3.241470e-01 10 119942174 119942892 719 + 0.956 1.138 0.665
ENSG00000107651 E043 30.6694309 0.0259585152 8.443541e-07 2.452801e-05 10 119942893 119944657 1765 + 1.254 1.735 1.652
ENSG00000107651 E044 0.1426347 0.0329003211 1.000000e+00   10 119949044 119949102 59 + 0.081 0.000 -9.018
ENSG00000107651 E045 0.2027342 0.0323123525 1.944156e-01   10 119949257 119949383 127 + 0.000 0.178 11.575
ENSG00000107651 E046 0.1308682 0.0326491905 1.956360e-01   10 119949987 119950083 97 + 0.000 0.177 11.568
ENSG00000107651 E047 0.0000000       10 119951401 119951429 29 +