ENSG00000107643

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374174 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding processed_transcript 10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 1.7561836 0.2850196 3.1414000 0.2850196 0.81846288 3.417110 0.10717500 0.08326667 0.14930000 0.06603333 5.043587e-01 2.255723e-06 FALSE TRUE
ENST00000395611 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding protein_coding 10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 0.3357021 0.1714750 0.0000000 0.1011493 0.00000000 -4.181699 0.03624583 0.07166667 0.00000000 -0.07166667 4.803247e-02 2.255723e-06 FALSE TRUE
ENST00000432379 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding protein_coding 10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 1.8373264 0.4044739 3.5266628 0.2033458 0.41887774 3.093035 0.12134583 0.14686667 0.17476667 0.02790000 9.040264e-01 2.255723e-06 FALSE FALSE
ENST00000471272 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding retained_intron 10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 0.9531668 0.2445118 1.7003402 0.1223695 0.88829384 2.748479 0.07384583 0.08573333 0.07416667 -0.01156667 9.954923e-01 2.255723e-06 FALSE TRUE
ENST00000476134 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding protein_coding 10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 0.3324202 0.2630621 0.6010145 0.1445522 0.06228359 1.161977 0.06638333 0.11046667 0.02930000 -0.08116667 7.456573e-01 2.255723e-06 FALSE TRUE
MSTRG.3948.4 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding   10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 2.0898793 0.6783327 3.9262141 0.2490275 0.36505000 2.515631 0.19055417 0.23546667 0.19626667 -0.03920000 9.088283e-01 2.255723e-06 FALSE TRUE
MSTRG.3948.5 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding   10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 0.9696420 0.1739742 0.9135869 0.0930994 0.36136711 2.327745 0.11826667 0.07460000 0.04973333 -0.02486667 9.527009e-01 2.255723e-06 FALSE TRUE
MSTRG.3948.8 ENSG00000107643 HEK293_OSMI2_6hA HEK293_TMG_6hB MAPK8 protein_coding   10.8487 2.713675 20.59723 0.3595606 2.389691 2.919524 0.4653008 0.0000000 2.0526292 0.0000000 0.24366035 7.688341 0.04026667 0.00000000 0.10010000 0.10010000 2.255723e-06 2.255723e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107643 E001 0.0000000       10 48306639 48306654 16 +      
ENSG00000107643 E002 0.1779838 0.0357676389 1.0000000000   10 48306655 48306661 7 + 0.054 0.000 -7.866
ENSG00000107643 E003 0.1779838 0.0357676389 1.0000000000   10 48306662 48306662 1 + 0.054 0.000 -9.969
ENSG00000107643 E004 0.6648197 0.5778598860 0.5665543027   10 48306663 48306676 14 + 0.151 0.245 0.873
ENSG00000107643 E005 1.1764059 0.5488253378 0.1686554330   10 48306677 48306679 3 + 0.192 0.519 2.051
ENSG00000107643 E006 3.4165309 0.1336220347 0.1824950974 0.407239942 10 48306680 48306693 14 + 0.479 0.754 1.214
ENSG00000107643 E007 13.2960059 0.0233747089 0.0002756818 0.003485231 10 48306694 48306752 59 + 0.914 1.360 1.605
ENSG00000107643 E008 23.9315297 0.0016472659 0.0032013792 0.024612605 10 48306753 48306821 69 + 1.207 1.466 0.904
ENSG00000107643 E009 0.0000000       10 48307026 48307147 122 +      
ENSG00000107643 E010 27.5515093 0.0012314462 0.4367746880 0.656271127 10 48308095 48308215 121 + 1.300 1.376 0.266
ENSG00000107643 E011 30.0302589 0.0011660500 0.4494541950 0.665280744 10 48308216 48308288 73 + 1.357 1.298 -0.205
ENSG00000107643 E012 17.9518881 0.0023139084 0.6953715634 0.832479639 10 48325897 48325965 69 + 1.129 1.180 0.182
ENSG00000107643 E013 0.1308682 0.0308389735 0.0634461843   10 48364612 48364656 45 + 0.000 0.251 12.430
ENSG00000107643 E014 33.5122963 0.0018237332 0.8493406802 0.924552474 10 48401612 48401642 31 + 1.397 1.390 -0.025
ENSG00000107643 E015 27.9100585 0.0131761828 0.6524769764 0.805048026 10 48401643 48401647 5 + 1.312 1.362 0.174
ENSG00000107643 E016 32.9466340 0.0206619355 0.8643062168 0.932768574 10 48401648 48401660 13 + 1.392 1.376 -0.057
ENSG00000107643 E017 61.3707273 0.0042118454 0.8012941176 0.897080697 10 48401661 48401782 122 + 1.653 1.645 -0.030
ENSG00000107643 E018 65.4030297 0.0017677589 0.6683566219 0.815131542 10 48404852 48404981 130 + 1.678 1.661 -0.059
ENSG00000107643 E019 61.3057338 0.0025548226 0.3002592418 0.540679312 10 48409879 48409937 59 + 1.635 1.710 0.254
ENSG00000107643 E020 94.6088473 0.0011762601 0.7334535606 0.856322431 10 48410030 48410168 139 + 1.829 1.855 0.090
ENSG00000107643 E021 1.7437355 0.0111582743 0.2875863562 0.528326924 10 48410169 48410328 160 + 0.314 0.526 1.152
ENSG00000107643 E022 115.3781417 0.0020398477 0.0426037853 0.161530277 10 48420155 48420320 166 + 1.931 1.836 -0.318
ENSG00000107643 E023 12.5172072 0.0045761854 0.0690996757 0.222974732 10 48424088 48424159 72 + 1.018 0.757 -0.998
ENSG00000107643 E024 48.9237702 0.0008037900 0.0426703992 0.161714468 10 48424514 48424518 5 + 1.572 1.430 -0.486
ENSG00000107643 E025 64.3537359 0.0006990726 0.0970791320 0.276659554 10 48424519 48424568 50 + 1.684 1.588 -0.327
ENSG00000107643 E026 41.3206975 0.0049655155 0.1153996958 0.308145637 10 48424569 48424585 17 + 1.502 1.376 -0.436
ENSG00000107643 E027 4.2653758 0.0482370696 0.6526964946 0.805204253 10 48425179 48425188 10 + 0.610 0.525 -0.390
ENSG00000107643 E028 4.9611029 0.0366029397 0.7880088691 0.889397523 10 48425189 48425219 31 + 0.637 0.693 0.236
ENSG00000107643 E029 10.3443280 0.0402061125 0.7052742212 0.838878972 10 48425220 48425749 530 + 0.923 0.863 -0.231
ENSG00000107643 E030 5.4054569 0.0050907512 0.3070409289 0.547644782 10 48425750 48425853 104 + 0.708 0.526 -0.802
ENSG00000107643 E031 4.1617287 0.0066054790 0.2777821476 0.517858450 10 48425854 48425887 34 + 0.621 0.410 -1.019
ENSG00000107643 E032 107.1177499 0.0006765449 0.0491102273 0.177462229 10 48425888 48426043 156 + 1.899 1.811 -0.298
ENSG00000107643 E033 59.5194957 0.0025242089 0.5952830556 0.767209088 10 48426044 48426070 27 + 1.640 1.613 -0.090
ENSG00000107643 E034 5.7346336 0.0049756428 0.8913302196 0.947289721 10 48426071 48426379 309 + 0.708 0.693 -0.065
ENSG00000107643 E035 93.7552302 0.0054140979 0.6549868503 0.806714776 10 48426380 48426504 125 + 1.833 1.815 -0.061
ENSG00000107643 E036 10.6240649 0.0028771438 0.0791052397 0.243041740 10 48426505 48427079 575 + 0.958 0.693 -1.040
ENSG00000107643 E037 84.9984369 0.0008048830 0.5003145081 0.700966095 10 48427080 48427143 64 + 1.793 1.766 -0.091
ENSG00000107643 E038 2.0332429 0.1082159676 0.1792487122 0.402947306 10 48427144 48427410 267 + 0.340 0.616 1.401
ENSG00000107643 E039 12.3100643 0.2008888541 0.1386505391 0.345462756 10 48429893 48431192 1300 + 0.898 1.301 1.460
ENSG00000107643 E040 87.7683154 0.0004810061 0.4854110473 0.690829830 10 48431193 48431270 78 + 1.797 1.841 0.150
ENSG00000107643 E041 38.2146978 0.0009011056 0.9574024168 0.980558188 10 48434879 48434883 5 + 1.450 1.455 0.017
ENSG00000107643 E042 458.2399063 0.0021001520 0.0938446494 0.270848216 10 48434884 48439360 4477 + 2.505 2.557 0.174