ENSG00000107554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324109 ENSG00000107554 HEK293_OSMI2_6hA HEK293_TMG_6hB DNMBP protein_coding protein_coding 4.697496 7.447071 3.826599 1.260256 0.3617085 -0.9587811 2.880077 4.019693 3.4446873 0.5980213 0.2464102 -0.2221148 0.6529375 0.5448000 0.90956667 0.3647667 0.04315813 0.04315813 FALSE TRUE
ENST00000543621 ENSG00000107554 HEK293_OSMI2_6hA HEK293_TMG_6hB DNMBP protein_coding protein_coding 4.697496 7.447071 3.826599 1.260256 0.3617085 -0.9587811 1.707220 3.136954 0.3011307 0.6371248 0.3011307 -3.3383633 0.3246250 0.4150333 0.06923333 -0.3458000 0.14135122 0.04315813 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107554 E001 249.8488640 1.1544680059 3.136049e-01 0.5538206740 10 99875577 99877042 1466 - 2.142 2.460 1.062
ENSG00000107554 E002 74.5255482 0.4812433402 2.782016e-01 0.5183203531 10 99877043 99877336 294 - 1.689 1.921 0.782
ENSG00000107554 E003 113.5169567 0.0016860920 7.269233e-01 0.8523630812 10 99879811 99880361 551 - 2.000 2.057 0.190
ENSG00000107554 E004 47.3670894 0.0028116808 2.541299e-01 0.4925539776 10 99884011 99884209 199 - 1.658 1.664 0.022
ENSG00000107554 E005 45.2982843 0.0250543136 7.685186e-01 0.8777466471 10 99885687 99885866 180 - 1.600 1.661 0.207
ENSG00000107554 E006 29.7405297 0.0210339947 8.806373e-01 0.9415705084 10 99886300 99886403 104 - 1.398 1.498 0.344
ENSG00000107554 E007 49.6759040 0.0086817062 5.511254e-01 0.7371217222 10 99886404 99886632 229 - 1.657 1.695 0.130
ENSG00000107554 E008 38.0455469 0.0021839917 3.723604e-01 0.6059522598 10 99888825 99888953 129 - 1.488 1.612 0.426
ENSG00000107554 E009 1.8515326 0.0109085351 8.875506e-03 0.0532602504 10 99888954 99889495 542 - 0.000 0.554 11.160
ENSG00000107554 E010 29.0844238 0.0016599502 5.145152e-01 0.7113597656 10 99894946 99895050 105 - 1.374 1.488 0.392
ENSG00000107554 E011 27.8019521 0.0013633359 7.520304e-01 0.8679533239 10 99896267 99896397 131 - 1.406 1.450 0.153
ENSG00000107554 E012 38.4303787 0.0363277552 1.204326e-01 0.3165351681 10 99898086 99898285 200 - 1.627 1.544 -0.282
ENSG00000107554 E013 14.7806912 0.0642258726 8.045530e-02 0.2457824023 10 99898743 99898760 18 - 1.285 1.113 -0.610
ENSG00000107554 E014 36.2706118 0.0437465724 4.886351e-02 0.1769183110 10 99899919 99900066 148 - 1.637 1.495 -0.485
ENSG00000107554 E015 33.8298124 0.0311963017 1.344647e-01 0.3388263048 10 99907995 99908094 100 - 1.563 1.490 -0.251
ENSG00000107554 E016 40.4442647 0.0098412516 7.765628e-02 0.2401147410 10 99908953 99909146 194 - 1.626 1.570 -0.190
ENSG00000107554 E017 0.8098394 0.0173699162 5.959297e-01   10 99913953 99914082 130 - 0.160 0.287 1.076
ENSG00000107554 E018 1.3334997 0.0170518889 5.713174e-01   10 99929608 99930996 1389 - 0.276 0.420 0.877
ENSG00000107554 E019 183.8731489 0.0005314778 9.008908e-06 0.0001918154 10 99955214 99957205 1992 - 2.278 2.229 -0.164
ENSG00000107554 E020 19.8468904 0.0018512796 4.512510e-02 0.1679402257 10 99969115 99969237 123 - 1.357 1.263 -0.329
ENSG00000107554 E021 23.1049532 0.0139179267 1.062848e-01 0.2928182002 10 99971980 99972134 155 - 1.406 1.327 -0.275
ENSG00000107554 E022 0.0000000       10 100006237 100006248 12 -      
ENSG00000107554 E023 12.6916143 0.0051654722 3.016835e-01 0.5422444154 10 100009838 100009947 110 - 1.143 1.104 -0.141