ENSG00000107521

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414009 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding protein_coding 58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 7.295228 11.8537558 4.100070 2.1269939 0.1960734 -1.5293259 0.11947500 0.13016667 0.11766667 -0.012500000 0.86851024 0.0007595163 FALSE TRUE
ENST00000474873 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding processed_transcript 58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 3.094140 3.7944979 2.047970 0.6887997 0.3622327 -0.8864842 0.06337500 0.04543333 0.05970000 0.014266667 0.83476690 0.0007595163 FALSE TRUE
ENST00000480020 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding processed_transcript 58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 4.621818 9.5936610 2.928094 1.4658540 1.5983663 -1.7087038 0.08135833 0.10656667 0.08186667 -0.024700000 0.88250496 0.0007595163 FALSE TRUE
MSTRG.4473.26 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding   58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 2.753430 0.8596453 6.124384 0.8596453 0.5755681 2.8184194 0.06653333 0.00800000 0.17673333 0.168733333 0.03716957 0.0007595163   FALSE
MSTRG.4473.27 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding   58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 3.003004 2.7281568 0.000000 1.5602537 0.0000000 -8.0970613 0.05165833 0.03586667 0.00000000 -0.035866667 0.45790808 0.0007595163   FALSE
MSTRG.4473.5 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding   58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 4.200814 5.7182753 2.011489 0.6669096 0.4757094 -1.5026825 0.06692917 0.06440000 0.05883333 -0.005566667 0.93954231 0.0007595163 FALSE TRUE
MSTRG.4473.7 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding   58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 3.997125 6.1918793 1.288716 1.1608140 0.6465478 -2.2556191 0.06457917 0.06783333 0.03636667 -0.031466667 0.77324501 0.0007595163 FALSE TRUE
MSTRG.4473.8 ENSG00000107521 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS1 protein_coding   58.38388 89.67408 34.81596 10.83241 1.342651 -1.364689 17.784971 30.8483887 8.756180 5.6464865 0.8350540 -1.8156425 0.28290000 0.33866667 0.25046667 -0.088200000 0.40811407 0.0007595163 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107521 E001 4.518615 0.0380100661 5.449769e-02 1.902317e-01 10 98415730 98415756 27 - 0.906 0.576 -1.351
ENSG00000107521 E002 24.317761 0.0016325438 2.477692e-01 4.855907e-01 10 98416198 98416359 162 - 1.246 1.329 0.294
ENSG00000107521 E003 44.598455 0.0043397860 7.456083e-01 8.640495e-01 10 98416360 98416483 124 - 1.601 1.555 -0.158
ENSG00000107521 E004 105.671510 0.0042659381 4.954135e-01 6.977269e-01 10 98416484 98416971 488 - 1.977 1.919 -0.197
ENSG00000107521 E005 16.870602 0.0027341517 2.220558e-01 4.559469e-01 10 98416972 98416972 1 - 1.262 1.127 -0.479
ENSG00000107521 E006 28.708428 0.0014582707 2.901376e-01 5.307485e-01 10 98416973 98417014 42 - 1.455 1.355 -0.343
ENSG00000107521 E007 32.746935 0.0010548447 3.069746e-01 5.475753e-01 10 98417015 98417037 23 - 1.509 1.419 -0.312
ENSG00000107521 E008 54.533838 0.0006704035 3.047424e-01 5.453405e-01 10 98417038 98417059 22 - 1.712 1.635 -0.259
ENSG00000107521 E009 230.050267 0.0008145338 7.540611e-03 4.722037e-02 10 98417060 98417198 139 - 2.218 2.286 0.226
ENSG00000107521 E010 375.382797 0.0002398930 8.627347e-05 1.320882e-03 10 98417199 98417392 194 - 2.423 2.498 0.249
ENSG00000107521 E011 548.311498 0.0001260852 5.943509e-06 1.337815e-04 10 98417393 98417726 334 - 2.591 2.659 0.226
ENSG00000107521 E012 3.384524 0.0079106227 4.289430e-01 6.502861e-01 10 98418152 98418174 23 - 0.684 0.537 -0.649
ENSG00000107521 E013 252.651856 0.0002508605 7.657043e-02 2.378877e-01 10 98418175 98418257 83 - 2.285 2.315 0.102
ENSG00000107521 E014 308.874874 0.0002374100 3.426578e-03 2.591804e-02 10 98420045 98420158 114 - 2.351 2.408 0.190
ENSG00000107521 E015 1.856420 0.0585333892 3.545977e-01 5.913799e-01 10 98420159 98420369 211 - 0.551 0.360 -0.985
ENSG00000107521 E016 313.632647 0.0010254004 1.232676e-02 6.774431e-02 10 98422369 98422513 145 - 2.360 2.412 0.176
ENSG00000107521 E017 115.861293 0.0040336500 7.034931e-02 2.254393e-01 10 98423603 98423607 5 - 1.913 1.987 0.248
ENSG00000107521 E018 121.857703 0.0015182525 1.205222e-01 3.166570e-01 10 98423608 98423616 9 - 1.956 2.005 0.164
ENSG00000107521 E019 203.773282 0.0002678110 4.816153e-05 8.055269e-04 10 98423617 98423668 52 - 2.127 2.240 0.378
ENSG00000107521 E020 288.435148 0.0001716898 2.489066e-05 4.597570e-04 10 98423753 98423879 127 - 2.292 2.386 0.315
ENSG00000107521 E021 146.249556 0.0003561627 4.306122e-02 1.627342e-01 10 98423880 98423887 8 - 2.030 2.086 0.189
ENSG00000107521 E022 195.702339 0.0003065025 4.072567e-03 2.957897e-02 10 98424313 98424374 62 - 2.139 2.214 0.251
ENSG00000107521 E023 342.529988 0.0002253816 6.998610e-04 7.442187e-03 10 98425541 98425720 180 - 2.389 2.454 0.217
ENSG00000107521 E024 227.475055 0.0029881467 2.786089e-01 5.186879e-01 10 98425818 98425905 88 - 2.244 2.267 0.077
ENSG00000107521 E025 207.566975 0.0003699772 2.928594e-01 5.335614e-01 10 98425906 98425985 80 - 2.214 2.228 0.047
ENSG00000107521 E026 9.950739 0.1703308555 5.461667e-01 7.335743e-01 10 98425986 98426103 118 - 1.049 0.922 -0.474
ENSG00000107521 E027 169.436031 0.0009923570 3.729714e-01 6.064968e-01 10 98427215 98427264 50 - 2.129 2.144 0.050
ENSG00000107521 E028 0.333790 0.0331755673 3.387602e-01   10 98429151 98429155 5 - 0.215 0.066 -1.970
ENSG00000107521 E029 6.856708 0.0047610467 2.660667e-01 5.055410e-01 10 98429156 98429299 144 - 0.684 0.837 0.615
ENSG00000107521 E030 76.791202 0.0004961038 4.845514e-01 6.902364e-01 10 98429300 98429458 159 - 1.841 1.789 -0.175
ENSG00000107521 E031 102.308896 0.0004834688 8.006437e-01 8.966776e-01 10 98429459 98429572 114 - 1.944 1.914 -0.100
ENSG00000107521 E032 277.322491 0.0015577110 6.589404e-01 8.093727e-01 10 98429573 98429642 70 - 2.355 2.351 -0.012
ENSG00000107521 E033 86.846655 0.0042153569 1.275522e-01 3.279730e-01 10 98429791 98429889 99 - 1.795 1.868 0.247
ENSG00000107521 E034 308.884104 0.0026892593 3.260138e-01 5.652453e-01 10 98430571 98430670 100 - 2.384 2.402 0.059
ENSG00000107521 E035 299.488641 0.0014104862 4.534942e-02 1.684593e-01 10 98431131 98431291 161 - 2.351 2.394 0.142
ENSG00000107521 E036 39.688298 0.0011262298 5.089396e-01 7.070952e-01 10 98433940 98433982 43 - 1.500 1.528 0.093
ENSG00000107521 E037 296.848514 0.0002082023 5.200423e-03 3.567712e-02 10 98433983 98434091 109 - 2.338 2.392 0.182
ENSG00000107521 E038 15.466607 0.0977946040 3.783619e-01 6.108196e-01 10 98435086 98435271 186 - 1.248 1.089 -0.568
ENSG00000107521 E039 333.236962 0.0001820726 9.778409e-01 9.907043e-01 10 98435272 98435414 143 - 2.446 2.428 -0.060
ENSG00000107521 E040 414.478619 0.0001774324 9.658888e-01 9.848355e-01 10 98435635 98435772 138 - 2.541 2.523 -0.060
ENSG00000107521 E041 44.997213 0.0452018469 1.066253e-07 3.927007e-06 10 98442388 98442480 93 - 1.983 1.344 -2.175
ENSG00000107521 E042 35.600082 0.0629795234 3.340679e-05 5.918257e-04 10 98442481 98442536 56 - 1.861 1.274 -2.009
ENSG00000107521 E043 126.724428 0.0633129180 1.660951e-06 4.432936e-05 10 98442537 98442957 421 - 2.422 1.791 -2.113
ENSG00000107521 E044 431.810904 0.0011262603 5.620978e-07 1.718400e-05 10 98443124 98443240 117 - 2.653 2.507 -0.488
ENSG00000107521 E045 340.146132 0.0002631107 1.940675e-08 8.529276e-07 10 98445300 98445404 105 - 2.553 2.406 -0.490
ENSG00000107521 E046 142.851585 0.0013233741 1.184292e-04 1.720162e-03 10 98445405 98445413 9 - 2.190 2.025 -0.554
ENSG00000107521 E047 16.141229 0.1195305667 4.910473e-01 6.947201e-01 10 98446647 98446806 160 - 1.087 1.160 0.261
ENSG00000107521 E048 185.765209 0.0002479107 2.706289e-06 6.790635e-05 10 98446807 98446886 80 - 2.302 2.142 -0.532
ENSG00000107521 E049 103.352696 0.0003674383 6.304677e-05 1.015825e-03 10 98446887 98448014 1128 - 2.062 1.885 -0.595