ENSG00000107485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346208 ENSG00000107485 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA3 protein_coding protein_coding 2.24018 3.259898 1.785699 0.3626452 0.05348744 -0.8647004 0.3169091 0.5681528 0.2517479 0.22312102 0.01485387 -1.143273 0.1353958 0.16200000 0.1407333 -0.02126667 1.0000000 0.0365164 FALSE TRUE
MSTRG.3515.1 ENSG00000107485 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA3 protein_coding   2.24018 3.259898 1.785699 0.3626452 0.05348744 -0.8647004 1.1990967 2.4060278 0.9140336 0.32381979 0.12131145 -1.386620 0.5133708 0.73373333 0.5143333 -0.21940000 0.2052044 0.0365164 FALSE TRUE
MSTRG.3515.4 ENSG00000107485 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA3 protein_coding   2.24018 3.259898 1.785699 0.3626452 0.05348744 -0.8647004 0.5589683 0.1159869 0.6199172 0.07375053 0.14124083 2.321888 0.2794500 0.04143333 0.3449667 0.30353333 0.0365164 0.0365164 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107485 E001 7.7431857 0.004417078 0.69176279 0.83018672 10 8045256 8045377 122 + 0.857 0.917 0.228
ENSG00000107485 E002 10.8604135 0.003565126 0.21546764 0.44800080 10 8045378 8045515 138 + 0.915 1.067 0.563
ENSG00000107485 E003 0.4812263 0.021459257 0.81744994   10 8050157 8050184 28 + 0.181 0.147 -0.358
ENSG00000107485 E004 1.4396852 0.013696863 0.01651283 0.08368422 10 8053604 8053778 175 + 0.613 0.205 -2.357
ENSG00000107485 E005 0.0000000       10 8054688 8054809 122 +      
ENSG00000107485 E006 0.2617363 0.140314251 0.69946332   10 8054810 8054891 82 + 0.001 0.145 7.900
ENSG00000107485 E007 44.6104376 0.004856126 0.93624293 0.97032848 10 8055287 8055896 610 + 1.610 1.620 0.034
ENSG00000107485 E008 19.4444316 0.001931024 0.62082185 0.78439560 10 8058305 8058398 94 + 1.230 1.282 0.181
ENSG00000107485 E009 47.2287516 0.001358382 0.47109125 0.68092135 10 8058399 8058841 443 + 1.604 1.653 0.165
ENSG00000107485 E010 10.9561442 0.087953469 0.72162733 0.84912196 10 8063993 8063995 3 + 1.053 1.028 -0.093
ENSG00000107485 E011 33.6394558 0.022400375 0.22870624 0.46370635 10 8063996 8064138 143 + 1.551 1.463 -0.301
ENSG00000107485 E012 30.1947639 0.010220530 0.12772321 0.32824363 10 8069473 8069598 126 + 1.518 1.411 -0.368
ENSG00000107485 E013 87.0720939 0.721086255 0.49184991 0.69522183 10 8073739 8075198 1460 + 1.845 1.915 0.237