ENSG00000107290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000224140 ENSG00000107290 HEK293_OSMI2_6hA HEK293_TMG_6hB SETX protein_coding protein_coding 6.514312 2.995208 10.40088 0.3815475 0.5071631 1.792556 2.8641611 0.8252086 5.49580965 0.1132495 0.59420547 2.72074632 0.3628083 0.2754000 0.525266667 0.2498667 4.438869e-03 2.064592e-10 FALSE TRUE
ENST00000436441 ENSG00000107290 HEK293_OSMI2_6hA HEK293_TMG_6hB SETX protein_coding protein_coding 6.514312 2.995208 10.40088 0.3815475 0.5071631 1.792556 1.2859343 1.1791896 1.11432782 0.3461791 0.15173540 -0.08091603 0.2350167 0.3752667 0.108000000 -0.2672667 1.557640e-02 2.064592e-10 FALSE TRUE
ENST00000477049 ENSG00000107290 HEK293_OSMI2_6hA HEK293_TMG_6hB SETX protein_coding processed_transcript 6.514312 2.995208 10.40088 0.3815475 0.5071631 1.792556 0.7558833 0.8248190 0.04825908 0.1706029 0.04825908 -3.84090872 0.2169917 0.2832333 0.005133333 -0.2781000 4.109575e-04 2.064592e-10 FALSE TRUE
MSTRG.33553.5 ENSG00000107290 HEK293_OSMI2_6hA HEK293_TMG_6hB SETX protein_coding   6.514312 2.995208 10.40088 0.3815475 0.5071631 1.792556 0.9780801 0.0000000 2.36872053 0.0000000 0.15806833 7.89404197 0.1001500 0.0000000 0.230400000 0.2304000 2.064592e-10 2.064592e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107290 E001 245.5593976 1.3713166921 0.1683177885 0.388325229 9 132261356 132263956 2601 - 2.088 2.695 2.026
ENSG00000107290 E002 90.4288028 0.8315729926 0.2661685097 0.505672228 9 132263957 132264570 614 - 1.759 2.114 1.194
ENSG00000107290 E003 20.2697624 0.4307468159 0.4952683640 0.697662962 9 132264571 132264587 17 - 1.188 1.350 0.571
ENSG00000107290 E004 42.0639066 0.6072005389 0.3415992565 0.579435250 9 132264588 132264730 143 - 1.465 1.721 0.873
ENSG00000107290 E005 54.4027603 0.6597926520 0.2539959740 0.492378867 9 132264731 132264985 255 - 1.544 1.896 1.194
ENSG00000107290 E006 1.8342652 0.0113296410 0.4102047151 0.636137956 9 132266127 132266249 123 - 0.341 0.578 1.224
ENSG00000107290 E007 8.6441329 0.1750436524 0.2815259831 0.521841875 9 132269403 132269489 87 - 0.815 1.110 1.103
ENSG00000107290 E008 36.3193734 0.5346812525 0.2502275011 0.488211129 9 132269615 132269702 88 - 1.379 1.714 1.144
ENSG00000107290 E009 44.2693940 0.0009091736 0.0461005582 0.170264568 9 132271710 132271808 99 - 1.493 1.748 0.869
ENSG00000107290 E010 3.8538002 0.3024313516 0.3291551038 0.568168184 9 132274923 132275255 333 - 0.616 0.495 -0.556
ENSG00000107290 E011 59.2031067 0.0528854554 0.6437599902 0.799383256 9 132275256 132275420 165 - 1.645 1.757 0.381
ENSG00000107290 E012 38.3486142 0.0890045055 0.1926008513 0.420271559 9 132277060 132277152 93 - 1.490 1.448 -0.145
ENSG00000107290 E013 46.2917997 0.0815840323 0.1603280822 0.377291660 9 132278070 132278257 188 - 1.572 1.530 -0.141
ENSG00000107290 E014 32.8745249 0.0414957898 0.1621345371 0.379949405 9 132281467 132281574 108 - 1.423 1.422 -0.004
ENSG00000107290 E015 0.4820342 0.0217681645 0.5078912676   9 132282770 132282792 23 - 0.161 0.000 -12.828
ENSG00000107290 E016 0.6246688 0.0199482828 0.3388779168   9 132282793 132282857 65 - 0.203 0.000 -13.242
ENSG00000107290 E017 0.1426347 0.0309356325 1.0000000000   9 132282858 132282874 17 - 0.060 0.000 -11.241
ENSG00000107290 E018 0.1426347 0.0309356325 1.0000000000   9 132282875 132282902 28 - 0.060 0.000 -11.241
ENSG00000107290 E019 1.6559215 0.0115460067 0.7058743970 0.839275097 9 132282903 132283263 361 - 0.370 0.379 0.051
ENSG00000107290 E020 40.3119311 0.0843589127 0.6278870457 0.789142041 9 132283264 132283413 150 - 1.482 1.600 0.403
ENSG00000107290 E021 31.5008650 0.0941798582 0.5728293217 0.752245699 9 132286423 132286494 72 - 1.382 1.492 0.378
ENSG00000107290 E022 0.3150090 0.0304575501 0.3714989570   9 132286495 132286497 3 - 0.060 0.230 2.225
ENSG00000107290 E023 36.6319941 0.1001981552 0.6697992830 0.816147718 9 132288236 132288351 116 - 1.441 1.561 0.413
ENSG00000107290 E024 40.9840294 0.0505106550 0.2994513727 0.539859981 9 132288550 132288651 102 - 1.504 1.556 0.178
ENSG00000107290 E025 54.1039547 0.0461606707 0.2271424069 0.461924014 9 132295872 132296028 157 - 1.623 1.661 0.131
ENSG00000107290 E026 49.7520637 0.0509556961 0.1637646641 0.382287132 9 132296887 132297054 168 - 1.593 1.597 0.014
ENSG00000107290 E027 49.0981773 0.0801370678 0.2437479859 0.480777388 9 132298080 132298274 195 - 1.588 1.601 0.046
ENSG00000107290 E028 24.7185845 0.0742986096 0.1765399683 0.399147903 9 132298275 132298312 38 - 1.309 1.283 -0.093
ENSG00000107290 E029 37.2203058 0.0609205271 0.5641650535 0.746256868 9 132300630 132300803 174 - 1.451 1.561 0.378
ENSG00000107290 E030 27.4431430 0.0013589930 0.8626767224 0.931836572 9 132311757 132311856 100 - 1.328 1.450 0.422
ENSG00000107290 E031 70.6094834 0.8033827873 0.5546795922 0.739550686 9 132326324 132326952 629 - 1.721 1.830 0.366
ENSG00000107290 E032 277.9393078 1.6128251513 0.8905654295 0.946970891 9 132326953 132330499 3547 - 2.347 2.257 -0.300
ENSG00000107290 E033 21.3333272 0.0024336866 0.0029685750 0.023209443 9 132331052 132331139 88 - 1.273 1.109 -0.583
ENSG00000107290 E034 31.6856161 0.0329599940 0.0031203253 0.024140267 9 132331277 132331448 172 - 1.434 1.232 -0.705
ENSG00000107290 E035 31.0987005 0.0619195579 0.0010335882 0.010165921 9 132334608 132334727 120 - 1.441 1.107 -1.172
ENSG00000107290 E036 41.0936049 0.0843437565 0.0007817079 0.008130825 9 132336296 132336515 220 - 1.560 1.192 -1.279
ENSG00000107290 E037 27.2368692 0.0573670910 0.0018416721 0.016000322 9 132342690 132342799 110 - 1.382 1.083 -1.059
ENSG00000107290 E038 31.9803201 0.0830883970 0.0016571766 0.014722268 9 132346261 132346471 211 - 1.455 1.102 -1.241
ENSG00000107290 E039 27.0726434 0.0776085064 0.0005168448 0.005829324 9 132349252 132349435 184 - 1.390 0.971 -1.494
ENSG00000107290 E040 21.0424966 0.0832414344 0.0011452948 0.011011221 9 132353649 132353755 107 - 1.285 0.863 -1.539
ENSG00000107290 E041 12.3221076 0.1105905250 0.0071529827 0.045339690 9 132354917 132355027 111 - 1.069 0.653 -1.616