ENSG00000107104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382289 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding protein_coding 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.5706970 0.8925273 0.08664813 0.4880056 0.08664813 -3.223157 0.09382500 0.1414667 0.01826667 -0.12320000 6.451962e-01 1.694778e-05 FALSE TRUE
ENST00000382297 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding protein_coding 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 1.2581569 0.8130192 2.00869898 0.4318822 0.11779541 1.294428 0.25070000 0.1482333 0.45510000 0.30686667 5.185958e-01 1.694778e-05 FALSE TRUE
ENST00000674102 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding protein_coding 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.3016397 0.7831315 0.21209910 0.1865366 0.21209910 -1.836356 0.05798333 0.1453000 0.04900000 -0.09630000 3.750371e-01 1.694778e-05 FALSE TRUE
ENST00000685947 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding protein_coding 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.1662804 0.0000000 0.31031959 0.0000000 0.25429165 5.001440 0.03137917 0.0000000 0.06616667 0.06616667 3.721579e-01 1.694778e-05 FALSE TRUE
ENST00000688321 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding retained_intron 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.0511576 0.0000000 0.27564485 0.0000000 0.02149814 4.836151 0.01075417 0.0000000 0.06256667 0.06256667 1.694778e-05 1.694778e-05 FALSE TRUE
ENST00000692345 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding protein_coding 5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.4420002 0.6420331 0.09773922 0.1383286 0.09773922 -2.597402 0.08234167 0.1156000 0.02313333 -0.09246667 2.546885e-01 1.694778e-05 FALSE TRUE
MSTRG.32308.24 ENSG00000107104 HEK293_OSMI2_6hA HEK293_TMG_6hB KANK1 protein_coding   5.37214 5.493311 4.434222 0.8841929 0.1591397 -0.308369 0.5215834 0.8123946 0.20563199 0.3789490 0.10620021 -1.931260 0.09334583 0.1419000 0.04816667 -0.09373333 6.375361e-01 1.694778e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107104 E001 0.1723744 0.033953400 0.6084435430   9 470291 470294 4 + 0.000 0.108 9.819
ENSG00000107104 E002 0.1723744 0.033953400 0.6084435430   9 470295 470297 3 + 0.000 0.108 11.962
ENSG00000107104 E003 2.1169682 0.223516129 0.0368146059 0.146426372 9 470298 470374 77 + 0.135 0.646 3.233
ENSG00000107104 E004 2.5568760 0.281545650 0.2616341989 0.500706148 9 470375 470555 181 + 0.323 0.668 1.728
ENSG00000107104 E005 2.5928453 0.088533338 0.2105208775 0.442439044 9 470556 470591 36 + 0.393 0.643 1.205
ENSG00000107104 E006 3.3380732 0.024650751 0.0358404423 0.143808039 9 470592 470677 86 + 0.392 0.745 1.635
ENSG00000107104 E007 1.8800549 0.011528709 0.0775754833 0.239991843 9 470678 470682 5 + 0.239 0.551 1.800
ENSG00000107104 E008 5.1646105 0.123976798 0.0617916412 0.206852787 9 470683 471261 579 + 0.507 0.914 1.700
ENSG00000107104 E009 2.7127548 0.029149169 0.2645184084 0.503754608 9 471262 471445 184 + 0.453 0.643 0.883
ENSG00000107104 E010 1.1622228 0.043732596 0.1110602323   9 471446 471448 3 + 0.136 0.432 2.212
ENSG00000107104 E011 2.0539772 0.010381787 0.1290890375 0.330347732 9 471449 471466 18 + 0.322 0.583 1.364
ENSG00000107104 E012 2.1850330 0.010050380 0.2552328969 0.493846532 9 471467 471586 120 + 0.392 0.583 0.948
ENSG00000107104 E013 1.8510707 0.020186588 0.6623670476 0.811358784 9 473194 473273 80 + 0.506 0.430 -0.381
ENSG00000107104 E014 7.7184346 0.018663955 0.1906132945 0.417678759 9 473274 475211 1938 + 0.837 1.002 0.624
ENSG00000107104 E015 1.8168190 0.011123401 0.9076362492 0.955962200 9 475212 475465 254 + 0.453 0.432 -0.110
ENSG00000107104 E016 0.0000000       9 476628 476769 142 +      
ENSG00000107104 E017 0.1308682 0.031072634 0.6099047658   9 484282 484491 210 + 0.000 0.108 11.969
ENSG00000107104 E018 1.2780092 0.562832027 0.5640586343   9 490985 492793 1809 + 0.234 0.435 1.272
ENSG00000107104 E019 0.0000000       9 504219 504243 25 +      
ENSG00000107104 E020 0.9568432 0.076577574 0.1899754149   9 504680 504683 4 + 0.136 0.382 1.939
ENSG00000107104 E021 1.1292176 0.210244763 0.1804916100   9 504684 504694 11 + 0.137 0.430 2.193
ENSG00000107104 E022 1.1292176 0.210244763 0.1804916100   9 504695 504701 7 + 0.137 0.430 2.193
ENSG00000107104 E023 1.2010836 0.120492947 0.1361645760   9 504702 504702 1 + 0.136 0.435 2.221
ENSG00000107104 E024 1.2010836 0.120492947 0.1361645760   9 504703 504703 1 + 0.136 0.435 2.221
ENSG00000107104 E025 1.3734580 0.212965055 0.1312776625   9 504704 504708 5 + 0.137 0.480 2.451
ENSG00000107104 E026 2.8594511 0.260377165 0.7458318369 0.864250720 9 504709 504717 9 + 0.512 0.620 0.496
ENSG00000107104 E027 3.2401691 0.237589261 0.7184771800 0.847295562 9 504718 504729 12 + 0.560 0.652 0.406
ENSG00000107104 E028 3.4540497 0.370150641 0.7880240911 0.889397523 9 504730 504732 3 + 0.563 0.686 0.538
ENSG00000107104 E029 8.2458601 0.081585609 0.8239768689 0.910260427 9 504733 504754 22 + 0.925 0.974 0.182
ENSG00000107104 E030 0.5061644 0.333739335 0.7851588853   9 506282 506516 235 + 0.136 0.197 0.645
ENSG00000107104 E031 0.3447487 0.474103855 0.3988624037   9 508789 508827 39 + 0.000 0.198 12.325
ENSG00000107104 E032 3.4140736 0.373128389 0.4683583377 0.678953273 9 523891 524006 116 + 0.516 0.697 0.804
ENSG00000107104 E033 0.1614157 0.032193921 0.3847066202   9 538437 538601 165 + 0.136 0.000 -13.078
ENSG00000107104 E034 0.0000000       9 539512 539515 4 +      
ENSG00000107104 E035 5.3007129 0.019889529 0.0017113642 0.015096042 9 539516 539591 76 + 0.453 0.938 2.061
ENSG00000107104 E036 6.0912238 0.007451490 0.0021552182 0.018109229 9 539592 539633 42 + 0.553 0.978 1.725
ENSG00000107104 E037 0.8150164 0.019863666 0.8706559079   9 539677 539703 27 + 0.239 0.267 0.210
ENSG00000107104 E038 1.2906332 0.136050655 0.3631483590   9 539704 539764 61 + 0.240 0.431 1.198
ENSG00000107104 E039 13.2084753 0.002423062 0.0259779849 0.115250120 9 540508 540667 160 + 1.008 1.220 0.765
ENSG00000107104 E040 0.0000000       9 547135 547137 3 +      
ENSG00000107104 E041 0.0000000       9 547138 547155 18 +      
ENSG00000107104 E042 0.0000000       9 547156 547316 161 +      
ENSG00000107104 E043 0.0000000       9 547317 547317 1 +      
ENSG00000107104 E044 0.0000000       9 547318 547341 24 +      
ENSG00000107104 E045 1.6849554 0.011311506 0.1207468656 0.317046167 9 549107 549189 83 + 0.239 0.514 1.627
ENSG00000107104 E046 12.5901358 0.002606504 0.0003758864 0.004495998 9 549190 549721 532 + 0.881 1.242 1.317
ENSG00000107104 E047 2.5817668 0.200421108 0.7800138903 0.884752763 9 549722 549967 246 + 0.555 0.526 -0.133
ENSG00000107104 E048 0.5059767 0.021241595 0.1299111242   9 587015 587414 400 + 0.000 0.267 13.484
ENSG00000107104 E049 9.2459822 0.050699152 0.5446134474 0.732363268 9 593609 596997 3389 + 1.062 0.974 -0.322
ENSG00000107104 E050 9.0786690 0.046510603 0.8884943660 0.945903726 9 676890 676917 28 + 0.976 1.000 0.089
ENSG00000107104 E051 14.7077820 0.025996883 0.1065508598 0.293245554 9 676918 677009 92 + 1.279 1.097 -0.645
ENSG00000107104 E052 0.0000000       9 686764 686786 23 +      
ENSG00000107104 E053 0.0000000       9 686787 686921 135 +      
ENSG00000107104 E054 0.0000000       9 693339 693343 5 +      
ENSG00000107104 E055 0.0000000       9 693344 693455 112 +      
ENSG00000107104 E056 0.0000000       9 693456 693625 170 +      
ENSG00000107104 E057 0.0000000       9 693626 693688 63 +      
ENSG00000107104 E058 0.0000000       9 693689 693702 14 +      
ENSG00000107104 E059 0.0000000       9 693703 693762 60 +      
ENSG00000107104 E060 0.0000000       9 693763 693782 20 +      
ENSG00000107104 E061 0.0000000       9 693783 693786 4 +      
ENSG00000107104 E062 0.0000000       9 706684 706888 205 +      
ENSG00000107104 E063 0.0000000       9 706889 707247 359 +      
ENSG00000107104 E064 25.3226448 0.013562151 0.0065687549 0.042551330 9 710804 711016 213 + 1.527 1.294 -0.808
ENSG00000107104 E065 22.5528427 0.001507850 0.0028938053 0.022764242 9 711017 711172 156 + 1.472 1.256 -0.751
ENSG00000107104 E066 180.1558360 0.002084754 0.0010002547 0.009918039 9 711173 713464 2292 + 2.304 2.210 -0.311
ENSG00000107104 E067 0.0000000       9 713465 713749 285 +      
ENSG00000107104 E068 28.5498914 0.004478908 0.7224398302 0.849596965 9 730051 730194 144 + 1.483 1.458 -0.086
ENSG00000107104 E069 19.5811436 0.003874520 0.2745384729 0.514522558 9 730195 730248 54 + 1.362 1.275 -0.305
ENSG00000107104 E070 0.1614157 0.032193921 0.3847066202   9 730249 731157 909 + 0.136 0.000 -13.078
ENSG00000107104 E071 26.4889042 0.001680979 0.0484590992 0.176087934 9 731158 731266 109 + 1.503 1.369 -0.462
ENSG00000107104 E072 0.4812263 0.021768165 0.7246399387   9 731267 731404 138 + 0.136 0.195 0.624
ENSG00000107104 E073 1.3226088 0.013846169 0.0772226644   9 731405 732377 973 + 0.506 0.195 -1.956
ENSG00000107104 E074 37.3859343 0.001298098 0.6839679323 0.825264383 9 732378 732617 240 + 1.560 1.582 0.076
ENSG00000107104 E075 5.1594426 0.005564787 0.0370166380 0.146943966 9 732618 734110 1493 + 0.921 0.644 -1.110
ENSG00000107104 E076 0.4341107 0.022786025 0.1311845275   9 734111 734162 52 + 0.000 0.267 13.476
ENSG00000107104 E077 3.3742008 0.006736308 0.2239217249 0.458110113 9 734163 734747 585 + 0.733 0.550 -0.789
ENSG00000107104 E078 20.4382442 0.007077190 0.1694507171 0.389843506 9 734748 734835 88 + 1.244 1.361 0.408
ENSG00000107104 E079 0.1723744 0.033953400 0.6084435430   9 735712 735780 69 + 0.000 0.108 11.962
ENSG00000107104 E080 0.2922838 0.026426267 0.8508961899   9 736352 736557 206 + 0.136 0.108 -0.376
ENSG00000107104 E081 39.8551644 0.002822559 0.7137185493 0.844198678 9 738285 738504 220 + 1.613 1.592 -0.074
ENSG00000107104 E082 32.3672424 0.060082980 0.5974695179 0.768614761 9 740792 740934 143 + 1.539 1.501 -0.128
ENSG00000107104 E083 30.3788136 0.028401053 0.6710345804 0.817008091 9 742205 742405 201 + 1.464 1.515 0.174
ENSG00000107104 E084 4.5257725 0.037818471 0.8744608687 0.938452431 9 742406 744490 2085 + 0.762 0.739 -0.094
ENSG00000107104 E085 21.2380597 0.023852156 0.7154689361 0.845209427 9 744491 744589 99 + 1.323 1.362 0.136
ENSG00000107104 E086 12.3760741 0.003384709 0.5604491462 0.743623812 9 744590 745172 583 + 1.092 1.147 0.197
ENSG00000107104 E087 86.7303532 0.002123723 0.2194469473 0.452761942 9 745173 746105 933 + 1.907 1.957 0.169