ENSG00000107036

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251879 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding protein_coding 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.2781707 0.15826182 0.7988179 0.04011208 0.19384916 2.2651071 0.07390000 0.1009667 0.10783333 0.006866667 9.718213e-01 2.413618e-09 FALSE TRUE
ENST00000414202 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding protein_coding 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 2.0154493 0.83512839 3.7313655 0.21124338 0.18474279 2.1463225 0.50972917 0.4983667 0.50510000 0.006733333 1.000000e+00 2.413618e-09 FALSE TRUE
ENST00000418622 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding protein_coding 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.2005639 0.53327201 0.0000000 0.19370095 0.00000000 -5.7636028 0.11317500 0.3061333 0.00000000 -0.306133333 1.217216e-08 2.413618e-09 FALSE TRUE
ENST00000490816 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding protein_coding 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.2422203 0.00000000 0.8868634 0.00000000 0.33208116 6.4868164 0.04776667 0.0000000 0.11976667 0.119766667 3.428032e-02 2.413618e-09 FALSE TRUE
ENST00000545243 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding nonsense_mediated_decay 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.1022897 0.09695692 0.0000000 0.09695692 0.00000000 -3.4189580 0.05600417 0.0424000 0.00000000 -0.042400000 6.306056e-01 2.413618e-09 FALSE TRUE
ENST00000545641 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding protein_coding 3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.7985810 0.00000000 1.8261323 0.00000000 0.06713586 7.5205262 0.12779583 0.0000000 0.24720000 0.247200000 2.413618e-09 2.413618e-09 FALSE TRUE
MSTRG.32370.2 ENSG00000107036 HEK293_OSMI2_6hA HEK293_TMG_6hB RIC1 protein_coding   3.892686 1.709032 7.392588 0.3877545 0.07163742 2.106434 0.2275711 0.07748128 0.1325687 0.05695115 0.07023170 0.7046112 0.06454583 0.0487000 0.01783333 -0.030866667 8.001813e-01 2.413618e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107036 E001 0.5474829 0.1997951886 1.287360e-02   9 5629025 5629106 82 + 0.000 0.444 14.191
ENSG00000107036 E002 0.6783511 0.0204695839 1.776599e-03   9 5629107 5629118 12 + 0.000 0.522 14.626
ENSG00000107036 E003 13.6107845 0.0028322026 6.259857e-01 7.879396e-01 9 5629119 5629453 335 + 1.077 1.157 0.291
ENSG00000107036 E004 17.0263122 0.0020558165 1.427166e-02 7.541405e-02 9 5656583 5656653 71 + 1.234 1.013 -0.795
ENSG00000107036 E005 15.5543299 0.0023719162 1.359802e-06 3.712631e-05 9 5656654 5656690 37 + 1.238 0.652 -2.227
ENSG00000107036 E006 22.2084075 0.0017791592 2.084787e-04 2.767056e-03 9 5689959 5690038 80 + 1.359 1.036 -1.147
ENSG00000107036 E007 0.4950181 0.0217681645 1.326593e-01   9 5712845 5713895 1051 + 0.072 0.335 2.696
ENSG00000107036 E008 24.9738826 0.0308863640 2.548845e-02 1.137197e-01 9 5713896 5714003 108 + 1.397 1.156 -0.845
ENSG00000107036 E009 24.5602191 0.0547124896 2.082842e-01 4.397682e-01 9 5720182 5720324 143 + 1.378 1.220 -0.556
ENSG00000107036 E010 27.7126943 0.0015386066 1.174569e-02 6.542104e-02 9 5720614 5720750 137 + 1.434 1.265 -0.587
ENSG00000107036 E011 20.9290883 0.0034379543 2.078986e-02 9.864241e-02 9 5732388 5732479 92 + 1.320 1.138 -0.642
ENSG00000107036 E012 16.4689163 0.0023868547 1.014684e-02 5.875703e-02 9 5738450 5738538 89 + 1.225 0.987 -0.857
ENSG00000107036 E013 24.8520956 0.0014587625 3.661801e-03 2.726643e-02 9 5742869 5743013 145 + 1.392 1.174 -0.764
ENSG00000107036 E014 18.2972645 0.0019208303 1.789950e-02 8.870993e-02 9 5743689 5743737 49 + 1.260 1.059 -0.718
ENSG00000107036 E015 33.0719350 0.0093174818 3.802991e-02 1.497103e-01 9 5745931 5746083 153 + 1.494 1.352 -0.487
ENSG00000107036 E016 45.6906112 0.0092175869 4.601970e-01 6.732601e-01 9 5747302 5747505 204 + 1.604 1.584 -0.068
ENSG00000107036 E017 0.6675801 0.6856909500 4.289363e-01   9 5748585 5748714 130 + 0.134 0.340 1.723
ENSG00000107036 E018 22.1692006 0.0172167698 5.826029e-01 7.587688e-01 9 5753200 5753238 39 + 1.276 1.356 0.278
ENSG00000107036 E019 19.3726498 0.0434935217 7.478409e-01 8.654096e-01 9 5753536 5753646 111 + 1.222 1.288 0.231
ENSG00000107036 E020 26.9922982 0.0202346934 9.044440e-01 9.541864e-01 9 5754841 5754930 90 + 1.374 1.388 0.048
ENSG00000107036 E021 31.3372137 0.0022094602 3.378825e-01 5.761682e-01 9 5756212 5756372 161 + 1.451 1.414 -0.126
ENSG00000107036 E022 28.8955229 0.0045483606 5.957966e-01 7.675905e-01 9 5757313 5757451 139 + 1.411 1.405 -0.021
ENSG00000107036 E023 30.0224667 0.0023637444 9.028740e-01 9.532807e-01 9 5762541 5762660 120 + 1.416 1.460 0.152
ENSG00000107036 E024 49.1814621 0.0008438646 4.183493e-01 6.423885e-01 9 5763140 5763396 257 + 1.612 1.692 0.270
ENSG00000107036 E025 60.7127176 0.0008877978 2.333540e-01 4.689919e-01 9 5763397 5763868 472 + 1.698 1.792 0.318
ENSG00000107036 E026 28.6343114 0.6850765035 2.598917e-01 4.989045e-01 9 5765414 5765572 159 + 1.311 1.616 1.052
ENSG00000107036 E027 25.8885649 0.6806383791 3.065784e-01 5.472192e-01 9 5765662 5765798 137 + 1.290 1.539 0.860
ENSG00000107036 E028 37.2976604 0.0131301418 1.523915e-02 7.898616e-02 9 5768970 5769256 287 + 1.456 1.680 0.766
ENSG00000107036 E029 6.6535954 0.0073808592 3.798596e-01 6.120692e-01 9 5769257 5769674 418 + 0.850 0.752 -0.388
ENSG00000107036 E030 25.7182736 0.0276761910 4.037395e-01 6.313266e-01 9 5770087 5770205 119 + 1.377 1.331 -0.160
ENSG00000107036 E031 21.6566799 0.0016664886 5.111946e-01 7.088716e-01 9 5770206 5770278 73 + 1.301 1.279 -0.078
ENSG00000107036 E032 32.8683563 0.0013960087 5.570285e-01 7.411644e-01 9 5772564 5772741 178 + 1.467 1.460 -0.023
ENSG00000107036 E033 31.6268231 0.0012793031 6.176359e-01 7.822319e-01 9 5772892 5773080 189 + 1.434 1.502 0.234
ENSG00000107036 E034 2.5449832 0.0110933329 5.157509e-02 1.834807e-01 9 5773081 5773204 124 + 0.567 0.199 -2.209
ENSG00000107036 E035 46.3011441 0.0011897903 7.809612e-03 4.843063e-02 9 5773958 5774357 400 + 1.562 1.744 0.620
ENSG00000107036 E036 150.1741112 0.0107772908 2.169868e-03 1.820390e-02 9 5774358 5776557 2200 + 2.051 2.254 0.677
ENSG00000107036 E037 3.3067268 0.0081835276 8.930168e-01 9.481565e-01 9 5776689 5776856 168 + 0.587 0.591 0.016
ENSG00000107036 E038 0.1779838 0.0399663623 1.000000e+00   9 5800920 5801045 126 + 0.072 0.000 -9.268