ENSG00000107021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372648 ENSG00000107021 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D13 protein_coding protein_coding 32.98284 46.90871 23.99187 7.402176 0.715627 -0.9670167 30.18010 44.57246 20.471338 6.924705 0.7956291 -1.122166 0.9061500 0.9512 0.8532667 -0.09793333 1.964438e-03 5.280722e-17 FALSE TRUE
MSTRG.33471.2 ENSG00000107021 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D13 protein_coding   32.98284 46.90871 23.99187 7.402176 0.715627 -0.9670167 1.27075 0.00000 3.231214 0.000000 0.6648661 8.340391 0.0511375 0.0000 0.1346333 0.13463333 5.280722e-17 5.280722e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107021 E001 1.440715 0.0127231678 6.857866e-01 8.263583e-01 9 128787253 128787262 10 + 0.302 0.390 0.537
ENSG00000107021 E002 3.885461 0.2660057879 7.601948e-01 8.726473e-01 9 128787263 128787269 7 + 0.712 0.627 -0.363
ENSG00000107021 E003 51.130124 0.0076662509 1.340697e-01 3.381998e-01 9 128787270 128787332 63 + 1.581 1.709 0.436
ENSG00000107021 E004 84.678853 0.0069624682 2.497064e-01 4.875517e-01 9 128787333 128787348 16 + 1.825 1.916 0.306
ENSG00000107021 E005 114.110084 0.0005090375 9.342875e-02 2.700839e-01 9 128787349 128787376 28 + 1.959 2.045 0.286
ENSG00000107021 E006 189.123551 0.0021538803 4.507337e-01 6.661928e-01 9 128788334 128788407 74 + 2.242 2.234 -0.026
ENSG00000107021 E007 0.000000       9 128789874 128789949 76 +      
ENSG00000107021 E008 174.486587 0.0035696673 1.346651e-01 3.391651e-01 9 128790735 128790775 41 + 2.231 2.188 -0.145
ENSG00000107021 E009 198.058334 0.0003513183 2.947841e-02 1.258101e-01 9 128791380 128791441 62 + 2.285 2.245 -0.134
ENSG00000107021 E010 244.002312 0.0005641995 1.333081e-02 7.177346e-02 9 128791594 128791693 100 + 2.379 2.334 -0.151
ENSG00000107021 E011 248.924246 0.0051723856 7.578943e-02 2.363503e-01 9 128792492 128792574 83 + 2.398 2.339 -0.198
ENSG00000107021 E012 324.753955 0.0015414215 3.537906e-02 1.425589e-01 9 128797055 128797214 160 + 2.500 2.460 -0.134
ENSG00000107021 E013 365.005953 0.0002282236 4.601302e-03 3.248399e-02 9 128803250 128803460 211 + 2.548 2.511 -0.123
ENSG00000107021 E014 353.209509 0.0002251077 1.596336e-03 1.429922e-02 9 128803956 128804119 164 + 2.540 2.496 -0.145
ENSG00000107021 E015 211.610479 0.0002301195 3.638485e-01 5.989201e-01 9 128805859 128805921 63 + 2.290 2.287 -0.011
ENSG00000107021 E016 247.485736 0.0014515979 2.227061e-01 4.566549e-01 9 128805922 128806019 98 + 2.368 2.350 -0.062
ENSG00000107021 E017 191.454766 0.0002745367 3.285302e-01 5.675235e-01 9 128806254 128806311 58 + 2.249 2.243 -0.022
ENSG00000107021 E018 2360.886681 0.0010553945 3.516253e-07 1.134601e-05 9 128807814 128810430 2617 + 3.276 3.352 0.251