ENSG00000106868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355396 ENSG00000106868 HEK293_OSMI2_6hA HEK293_TMG_6hB SUSD1 protein_coding protein_coding 2.648084 1.952479 2.339241 0.2677431 0.2076547 0.2595175 0.1496230 0.00000 0.2804799 0.0000000 0.1706753 4.8603664 0.05430833 0.0000000 0.13550000 0.13550000 0.39033011 0.03706619 FALSE TRUE
ENST00000374270 ENSG00000106868 HEK293_OSMI2_6hA HEK293_TMG_6hB SUSD1 protein_coding protein_coding 2.648084 1.952479 2.339241 0.2677431 0.2076547 0.2595175 2.1086730 1.86513 1.6710741 0.2170804 0.2857419 -0.1576071 0.81256250 0.9602667 0.70840000 -0.25186667 0.03706619 0.03706619 FALSE TRUE
MSTRG.33232.5 ENSG00000106868 HEK293_OSMI2_6hA HEK293_TMG_6hB SUSD1 protein_coding   2.648084 1.952479 2.339241 0.2677431 0.2076547 0.2595175 0.1200516 0.00000 0.1285450 0.0000000 0.1285450 3.7922823 0.04098750 0.0000000 0.05393333 0.05393333 0.86862177 0.03706619 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106868 E001 1.7662029 0.129112516 0.52467264 0.71824176 9 112040783 112040784 2 - 0.485 0.354 -0.704
ENSG00000106868 E002 14.6412635 0.002930722 0.03294341 0.13590878 9 112040785 112041078 294 - 1.073 1.262 0.674
ENSG00000106868 E003 5.6181951 0.005851288 0.01262168 0.06893014 9 112041079 112041082 4 - 0.607 0.940 1.339
ENSG00000106868 E004 22.0302371 0.002201997 0.54390347 0.73185421 9 112041083 112041257 175 - 1.335 1.377 0.144
ENSG00000106868 E005 26.5733051 0.006042443 0.29088799 0.53150421 9 112041258 112041492 235 - 1.398 1.472 0.257
ENSG00000106868 E006 12.2742628 0.024232452 0.18931890 0.41612570 9 112041867 112041960 94 - 1.032 1.184 0.549
ENSG00000106868 E007 0.4929928 0.022898679 0.51915571   9 112042101 112042165 65 - 0.224 0.117 -1.133
ENSG00000106868 E008 0.3751086 0.027442404 0.22347400   9 112052155 112052349 195 - 0.000 0.209 11.502
ENSG00000106868 E009 8.4277168 0.023998226 0.05580536 0.19318412 9 112052399 112052438 40 - 0.828 1.072 0.917
ENSG00000106868 E010 23.7353696 0.013409869 0.62110778 0.78459915 9 112058428 112058686 259 - 1.378 1.417 0.133
ENSG00000106868 E011 16.5012999 0.002387055 0.45016334 0.66580232 9 112062937 112063033 97 - 1.210 1.269 0.208
ENSG00000106868 E012 20.1870387 0.001931708 0.37795481 0.61050818 9 112078538 112078724 187 - 1.284 1.348 0.222
ENSG00000106868 E013 15.8884424 0.002214712 0.19164785 0.41896546 9 112080074 112080165 92 - 1.162 1.269 0.379
ENSG00000106868 E014 18.6708186 0.002277226 0.83741341 0.91800057 9 112098470 112098581 112 - 1.277 1.290 0.047
ENSG00000106868 E015 12.8331444 0.006629066 0.55542099 0.74005146 9 112098582 112098662 81 - 1.172 1.114 -0.210
ENSG00000106868 E016 11.8969876 0.002812352 0.16108713 0.37842964 9 112102176 112102285 110 - 1.172 1.036 -0.492
ENSG00000106868 E017 0.1614157 0.032187689 0.44929566   9 112103129 112103163 35 - 0.126 0.000 -10.802
ENSG00000106868 E018 0.0000000       9 112104729 112104958 230 -      
ENSG00000106868 E019 0.1614157 0.032187689 0.44929566   9 112111650 112111653 4 - 0.126 0.000 -10.802
ENSG00000106868 E020 17.0329813 0.002023882 0.95745201 0.98057142 9 112111654 112111840 187 - 1.253 1.254 0.004
ENSG00000106868 E021 0.0000000       9 112111841 112112083 243 -      
ENSG00000106868 E022 9.8203352 0.006045917 0.07254379 0.22987768 9 112112771 112112791 21 - 1.119 0.925 -0.714
ENSG00000106868 E023 13.5120654 0.009229369 0.12214245 0.31925580 9 112112792 112112868 77 - 1.236 1.083 -0.546
ENSG00000106868 E024 11.7810891 0.081399880 0.31799274 0.55792299 9 112124257 112124295 39 - 1.184 1.029 -0.557
ENSG00000106868 E025 17.5385681 0.003047560 0.09879026 0.27968784 9 112124296 112124436 141 - 1.335 1.198 -0.480
ENSG00000106868 E026 20.3401092 0.002170035 0.91201911 0.95816412 9 112142320 112142499 180 - 1.334 1.323 -0.040
ENSG00000106868 E027 0.0000000       9 112142500 112142588 89 -      
ENSG00000106868 E028 19.9292756 0.002718020 0.21014247 0.44202069 9 112143471 112143623 153 - 1.361 1.262 -0.346
ENSG00000106868 E029 0.4764247 0.021768165 0.52025651   9 112145979 112146176 198 - 0.224 0.117 -1.132
ENSG00000106868 E030 14.6908479 0.025174846 0.10112688 0.28383418 9 112149244 112149399 156 - 1.269 1.091 -0.633
ENSG00000106868 E031 8.4130375 0.022714245 0.13334338 0.33701695 9 112157500 112157613 114 - 1.048 0.859 -0.705
ENSG00000106868 E032 0.0000000       9 112173091 112173143 53 -      
ENSG00000106868 E033 3.2912905 0.032376931 0.53684754 0.72691586 9 112175133 112175297 165 - 0.570 0.672 0.446