ENSG00000106689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373615 ENSG00000106689 HEK293_OSMI2_6hA HEK293_TMG_6hB LHX2 protein_coding protein_coding 2.081902 2.395543 0.940082 0.269582 0.09367458 -1.340239 0.5302570 0.94271256 0.1037549 0.21359574 0.007206609 -3.066112 0.25319583 0.39073333 0.1129333 -0.27780000 0.05940415 0.04045068 FALSE TRUE
ENST00000446480 ENSG00000106689 HEK293_OSMI2_6hA HEK293_TMG_6hB LHX2 protein_coding protein_coding 2.081902 2.395543 0.940082 0.269582 0.09367458 -1.340239 0.1411775 0.07046226 0.0000000 0.07046226 0.000000000 -3.008312 0.06980417 0.02450000 0.0000000 -0.02450000 0.95223836 0.04045068 FALSE TRUE
ENST00000488674 ENSG00000106689 HEK293_OSMI2_6hA HEK293_TMG_6hB LHX2 protein_coding protein_coding 2.081902 2.395543 0.940082 0.269582 0.09367458 -1.340239 0.1527878 0.11002196 0.0000000 0.11002196 0.000000000 -3.585227 0.05154167 0.05663333 0.0000000 -0.05663333 0.97856535 0.04045068 FALSE FALSE
MSTRG.33345.1 ENSG00000106689 HEK293_OSMI2_6hA HEK293_TMG_6hB LHX2 protein_coding   2.081902 2.395543 0.940082 0.269582 0.09367458 -1.340239 1.0306942 0.35916348 0.8363270 0.35916348 0.094155143 1.196955 0.54090000 0.15166667 0.8870667 0.73540000 0.04045068 0.04045068 FALSE TRUE
MSTRG.33345.3 ENSG00000106689 HEK293_OSMI2_6hA HEK293_TMG_6hB LHX2 protein_coding   2.081902 2.395543 0.940082 0.269582 0.09367458 -1.340239 0.2269854 0.91318278 0.0000000 0.49056536 0.000000000 -6.528544 0.08456667 0.37650000 0.0000000 -0.37650000 0.39576410 0.04045068 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106689 E001 0.9995898 0.046071142 0.12374222   9 124000194 124000249 56 + 0.455 0.178 -1.870
ENSG00000106689 E002 0.0000000       9 124001670 124001697 28 +      
ENSG00000106689 E003 0.5955263 0.021768165 0.85633570   9 124008837 124008897 61 + 0.209 0.177 -0.296
ENSG00000106689 E004 8.1940138 0.004120291 0.01074489 0.06130227 9 124011768 124012356 589 + 0.541 0.950 1.676
ENSG00000106689 E005 5.2704669 0.007512341 0.22003962 0.45355864 9 124012357 124012468 112 + 0.541 0.757 0.932
ENSG00000106689 E006 12.2410358 0.003104775 0.14083948 0.34880318 9 124013961 124014163 203 + 1.145 1.011 -0.487
ENSG00000106689 E007 0.1308682 0.033450159 1.00000000   9 124015098 124015121 24 + 0.000 0.067 7.450
ENSG00000106689 E008 13.8536974 0.004059470 0.27784626 0.51790924 9 124015122 124015396 275 + 1.164 1.076 -0.317
ENSG00000106689 E009 8.7135652 0.005606040 0.42591451 0.64793826 9 124015397 124015525 129 + 0.817 0.941 0.473
ENSG00000106689 E010 19.2126251 0.002245232 0.35680814 0.59317712 9 124021099 124021304 206 + 1.277 1.217 -0.212
ENSG00000106689 E011 0.0000000       9 124021819 124021867 49 +      
ENSG00000106689 E012 44.6590871 0.241402966 0.42551956 0.64769116 9 124032420 124033301 882 + 1.530 1.584 0.185