ENSG00000106683

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336180 ENSG00000106683 HEK293_OSMI2_6hA HEK293_TMG_6hB LIMK1 protein_coding protein_coding 20.02406 28.87309 10.88341 6.008553 0.2566927 -1.40677 15.097811 25.13980 7.347422 5.6823380 0.3052221 -1.7732744 0.7442333 0.8614000 0.6747000 -0.1867 0.012567050 0.002277952 FALSE TRUE
ENST00000435201 ENSG00000106683 HEK293_OSMI2_6hA HEK293_TMG_6hB LIMK1 protein_coding nonsense_mediated_decay 20.02406 28.87309 10.88341 6.008553 0.2566927 -1.40677 4.468891 3.25305 3.013036 0.6042462 0.1844088 -0.1102231 0.2262417 0.1169667 0.2771667 0.1602 0.002277952 0.002277952 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106683 E001 0.0000000       7 74082933 74083179 247 +      
ENSG00000106683 E002 7.5041068 0.0039508257 4.628931e-01 0.6750577148 7 74083804 74083990 187 + 0.790 0.896 0.411
ENSG00000106683 E003 32.5701454 0.0039306919 3.937492e-01 0.6233169953 7 74083991 74084045 55 + 1.506 1.443 -0.215
ENSG00000106683 E004 82.5644682 0.0004989503 2.704415e-01 0.5104268960 7 74085748 74085844 97 + 1.892 1.850 -0.143
ENSG00000106683 E005 0.1723744 0.0591589708 1.000000e+00   7 74093079 74093299 221 + 0.001 0.072 7.263
ENSG00000106683 E006 0.0000000       7 74093956 74094232 277 +      
ENSG00000106683 E007 0.0000000       7 74094233 74094275 43 +      
ENSG00000106683 E008 0.0000000       7 74094276 74094332 57 +      
ENSG00000106683 E009 139.2708684 0.0004439069 1.174762e-01 0.3116044531 7 74096622 74096760 139 + 2.121 2.073 -0.161
ENSG00000106683 E010 88.9898667 0.0005170031 2.035817e-01 0.4340329150 7 74097080 74097102 23 + 1.929 1.881 -0.162
ENSG00000106683 E011 133.3257746 0.0012187999 2.714366e-01 0.5113425337 7 74097103 74097189 87 + 2.093 2.055 -0.127
ENSG00000106683 E012 212.2898465 0.0002408355 5.597459e-02 0.1935923867 7 74099032 74099238 207 + 2.301 2.255 -0.153
ENSG00000106683 E013 160.4665405 0.0020332894 7.893521e-01 0.8901013258 7 74105875 74105980 106 + 2.144 2.141 -0.011
ENSG00000106683 E014 181.9337722 0.0036861894 7.305393e-01 0.8545330349 7 74106077 74106243 167 + 2.178 2.202 0.078
ENSG00000106683 E015 115.8456600 0.0004915862 1.133156e-02 0.0637259962 7 74107010 74107070 61 + 1.920 2.029 0.365
ENSG00000106683 E016 168.4659646 0.0004818936 8.763347e-01 0.9394039006 7 74107071 74107193 123 + 2.164 2.166 0.006
ENSG00000106683 E017 178.8242269 0.0003226879 1.785820e-02 0.0885589863 7 74107871 74107957 87 + 2.238 2.173 -0.216
ENSG00000106683 E018 211.9924732 0.0006670309 5.220684e-01 0.7163629460 7 74108905 74109036 132 + 2.273 2.257 -0.051
ENSG00000106683 E019 22.2273651 0.1369996756 2.022229e-02 0.0966593541 7 74109037 74111440 2404 + 1.583 1.149 -1.511
ENSG00000106683 E020 175.3566791 0.0038408926 6.001118e-01 0.7702865903 7 74111648 74111707 60 + 2.198 2.172 -0.086
ENSG00000106683 E021 180.2840139 0.0014470951 7.828893e-01 0.8863359857 7 74111933 74111998 66 + 2.184 2.194 0.034
ENSG00000106683 E022 2.3620891 0.0289200201 3.631121e-01 0.5982284574 7 74115368 74115801 434 + 0.588 0.421 -0.811
ENSG00000106683 E023 246.1892123 0.0012455349 4.508723e-01 0.6662937707 7 74115802 74115958 157 + 2.308 2.331 0.076
ENSG00000106683 E024 138.6907577 0.0027390218 3.010050e-01 0.5414595488 7 74120583 74120638 56 + 2.110 2.066 -0.149
ENSG00000106683 E025 172.5722594 0.0004024243 8.144891e-01 0.9049331672 7 74120892 74121049 158 + 2.164 2.178 0.046
ENSG00000106683 E026 689.4396258 0.0013084739 4.744206e-05 0.0007954145 7 74121139 74122525 1387 + 2.702 2.790 0.294