ENSG00000106682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265753 ENSG00000106682 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF4H protein_coding protein_coding 261.3299 288.4809 221.313 47.82686 9.273386 -0.3823721 88.91894 88.23424 91.86748 14.97152 1.564382 0.05820911 0.3440792 0.3053667 0.4159667 0.1106 0.0002391594 0.0002391594 FALSE TRUE
ENST00000353999 ENSG00000106682 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF4H protein_coding protein_coding 261.3299 288.4809 221.313 47.82686 9.273386 -0.3823721 161.20580 188.38920 116.17494 34.64291 7.575119 -0.69736977 0.6104042 0.6480000 0.5239000 -0.1241 0.0133551580 0.0002391594 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106682 E001 0.1308682 3.264919e-02 7.077983e-01   7 74174175 74174230 56 + 0.000 0.101 8.968
ENSG00000106682 E002 0.3336024 2.444117e-02 3.438794e-01   7 74174231 74174269 39 + 0.000 0.184 11.386
ENSG00000106682 E003 6.8295164 6.103212e-02 1.139039e-01 3.056182e-01 7 74174270 74174330 61 + 0.692 0.990 1.161
ENSG00000106682 E004 12.4973551 1.079779e-02 2.241820e-02 1.039714e-01 7 74174331 74174352 22 + 0.948 1.217 0.973
ENSG00000106682 E005 22.3913395 4.881951e-03 4.348004e-01 6.548400e-01 7 74174353 74174355 3 + 1.317 1.396 0.273
ENSG00000106682 E006 25.5824138 1.159930e-02 2.443729e-01 4.814924e-01 7 74174356 74174357 2 + 1.341 1.465 0.427
ENSG00000106682 E007 26.3736599 8.509942e-03 2.160598e-01 4.486992e-01 7 74174358 74174358 1 + 1.356 1.477 0.418
ENSG00000106682 E008 956.3209359 1.122747e-03 6.167454e-01 7.815419e-01 7 74174359 74174442 84 + 2.960 2.981 0.070
ENSG00000106682 E009 0.3751086 2.832359e-02 3.406340e-01   7 74178656 74178826 171 + 0.000 0.184 11.320
ENSG00000106682 E010 0.1308682 3.264919e-02 7.077983e-01   7 74179338 74179418 81 + 0.000 0.101 10.247
ENSG00000106682 E011 0.6783511 1.937411e-02 9.155126e-02   7 74183822 74183921 100 + 0.000 0.313 12.505
ENSG00000106682 E012 1995.4313485 2.442410e-04 1.508112e-03 1.367098e-02 7 74187611 74187798 188 + 3.305 3.284 -0.070
ENSG00000106682 E013 1331.4876720 8.403892e-05 5.493278e-10 3.358117e-08 7 74189673 74189737 65 + 3.147 3.096 -0.171
ENSG00000106682 E014 1.7365104 1.640993e-01 5.331456e-01 7.242942e-01 7 74189738 74189821 84 + 0.340 0.490 0.818
ENSG00000106682 E015 1605.3720188 8.981098e-05 6.052187e-07 1.833067e-05 7 74189822 74189918 97 + 3.219 3.184 -0.116
ENSG00000106682 E016 36.7448985 9.424471e-02 1.166434e-01 3.102365e-01 7 74189919 74190246 328 + 1.687 1.464 -0.761
ENSG00000106682 E017 541.2469819 1.631083e-04 1.825880e-19 4.956525e-17 7 74190247 74190306 60 + 2.801 2.668 -0.442
ENSG00000106682 E018 337.4842495 8.242590e-02 2.525142e-01 4.906152e-01 7 74192702 74194740 2039 + 2.594 2.463 -0.439
ENSG00000106682 E019 2104.9810024 3.191848e-04 8.693978e-01 9.355567e-01 7 74194741 74194878 138 + 3.306 3.319 0.043
ENSG00000106682 E020 5.9563772 4.762272e-02 9.297685e-01 9.668843e-01 7 74194879 74195059 181 + 0.817 0.835 0.070
ENSG00000106682 E021 18.0046411 3.660226e-02 6.293261e-01 7.900488e-01 7 74195060 74195168 109 + 1.299 1.245 -0.189
ENSG00000106682 E022 992.0434126 1.150491e-03 3.810597e-01 6.130550e-01 7 74195169 74195170 2 + 2.990 2.984 -0.022
ENSG00000106682 E023 4323.6668306 2.182182e-04 1.321806e-01 3.352446e-01 7 74195171 74195856 686 + 3.612 3.636 0.079
ENSG00000106682 E024 4879.1824316 4.497274e-04 4.629533e-11 3.516105e-09 7 74195857 74196641 785 + 3.632 3.707 0.248
ENSG00000106682 E025 1606.5715649 1.263230e-03 7.313892e-01 8.550530e-01 7 74196642 74197192 551 + 3.185 3.203 0.060