ENSG00000106610

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352103 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 0.8781350 0.1381894 0.8382219 0.1381894 0.5846925 2.5169993 0.07186250 0.02393333 0.07313333 0.049200000 0.75892384 0.04390224   FALSE
ENST00000416602 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene processed_transcript 11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 0.9671210 0.3287831 0.9043923 0.1690318 0.4548569 1.4324511 0.07403333 0.05420000 0.08756667 0.033366667 0.97282363 0.04390224 FALSE TRUE
ENST00000472361 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene retained_intron 11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 2.0735011 1.4542775 2.5718880 0.6277938 0.2133827 0.8182374 0.18938333 0.22553333 0.23983333 0.014300000 0.95291392 0.04390224   FALSE
ENST00000687534 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene processed_transcript 11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 0.9215500 0.5617992 0.8866610 0.1183889 0.3854068 0.6490542 0.08683333 0.08856667 0.07956667 -0.009000000 0.93324251 0.04390224 FALSE TRUE
ENST00000689067 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene processed_transcript 11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 1.0964853 0.3609995 2.1088138 0.1403426 0.2183484 2.5137678 0.09348333 0.05690000 0.19666667 0.139766667 0.04390224 0.04390224 TRUE TRUE
MSTRG.29986.1 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene   11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 0.7816442 0.5635522 0.8248548 0.2858254 0.2928994 0.5416004 0.07293333 0.08636667 0.07693333 -0.009433333 0.99541106 0.04390224 TRUE TRUE
MSTRG.29986.3 ENSG00000106610 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG3L4 transcribed_unprocessed_pseudogene   11.20996 6.272397 10.82405 0.2494444 0.4960392 0.7861853 3.0799828 2.0038029 1.2281752 0.6050608 0.6143028 -0.7017070 0.28494167 0.32716667 0.11143333 -0.215733333 0.66191043 0.04390224 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106610 E001 2.2852337 0.0094865151 1.152717e-01 0.3079067609 7 67302621 67302652 32 + 0.381 0.637 1.245
ENSG00000106610 E002 2.1128594 0.0103985626 1.862639e-01 0.4121205189 7 67302653 67302653 1 + 0.381 0.598 1.075
ENSG00000106610 E003 2.1128594 0.0103985626 1.862639e-01 0.4121205189 7 67302654 67302654 1 + 0.381 0.598 1.075
ENSG00000106610 E004 2.1128594 0.0103985626 1.862639e-01 0.4121205189 7 67302655 67302658 4 + 0.381 0.598 1.075
ENSG00000106610 E005 4.6237107 0.0065291817 8.704194e-01 0.9361623654 7 67302659 67302669 11 + 0.762 0.736 -0.106
ENSG00000106610 E006 16.1080595 0.0026958671 1.391604e-01 0.3462759736 7 67302670 67302673 4 + 1.178 1.298 0.424
ENSG00000106610 E007 41.7853614 0.0011077384 1.143369e-01 0.3063726444 7 67302674 67302765 92 + 1.591 1.671 0.274
ENSG00000106610 E008 26.8509289 0.0028022153 3.212143e-01 0.5607250006 7 67302766 67302775 10 + 1.411 1.476 0.225
ENSG00000106610 E009 25.3139574 0.0152493645 5.808892e-01 0.7577727207 7 67302776 67302777 2 + 1.394 1.444 0.173
ENSG00000106610 E010 49.6731952 0.0010954046 3.772885e-01 0.6101173577 7 67302778 67302885 108 + 1.686 1.726 0.135
ENSG00000106610 E011 40.4300908 0.0044582573 2.850546e-01 0.5256686912 7 67305987 67306083 97 + 1.642 1.575 -0.229
ENSG00000106610 E012 10.3737732 0.0590680846 1.711364e-01 0.3920373120 7 67308577 67308652 76 + 1.133 0.920 -0.783
ENSG00000106610 E013 17.9794420 0.0639434686 4.497573e-01 0.6655057348 7 67308653 67308934 282 + 1.308 1.227 -0.283
ENSG00000106610 E014 96.0060988 0.0033778710 3.970852e-01 0.6260022688 7 67308935 67309139 205 + 1.972 2.002 0.100
ENSG00000106610 E015 83.5017658 0.0006385458 1.956796e-01 0.4241882637 7 67309564 67309715 152 + 1.902 1.946 0.149
ENSG00000106610 E016 52.6331234 0.0065161860 6.199524e-01 0.7837968468 7 67320103 67320336 234 + 1.737 1.703 -0.115
ENSG00000106610 E017 28.0158759 0.0018588949 3.357217e-02 0.1376832775 7 67320337 67321526 1190 + 1.523 1.379 -0.496
ENSG00000106610 E018 8.5851714 0.0344947516 2.843417e-02 0.1226013417 7 67330263 67330394 132 + 1.091 0.786 -1.149
ENSG00000106610 E019 14.2606104 0.0030980042 4.367910e-06 0.0001023839 7 67330395 67330891 497 + 1.322 0.863 -1.667
ENSG00000106610 E020 4.1638696 0.0060606211 9.484354e-02 0.2726871442 7 67335447 67335526 80 + 0.803 0.555 -1.047
ENSG00000106610 E021 0.7796672 0.0182053320 4.542947e-01   7 67335819 67335975 157 + 0.194 0.324 0.980
ENSG00000106610 E022 1.4456546 0.0126790847 9.297309e-01 0.9668568296 7 67335976 67336025 50 + 0.381 0.395 0.075
ENSG00000106610 E023 1.1306456 0.0137840980 9.952092e-01   7 67336026 67336044 19 + 0.327 0.324 -0.019
ENSG00000106610 E024 1.7968206 0.0115690819 2.900630e-01 0.5306370358 7 67336045 67336112 68 + 0.512 0.325 -1.017
ENSG00000106610 E025 3.0995508 0.0087136275 1.014774e-01 0.2844746860 7 67336113 67336735 623 + 0.717 0.455 -1.189
ENSG00000106610 E026 2.3881425 0.0445863171 2.372992e-01 0.4734357849 7 67339450 67339573 124 + 0.429 0.636 0.983
ENSG00000106610 E027 0.9598639 0.3350409212 7.387224e-01   7 67339574 67339610 37 + 0.267 0.323 0.382
ENSG00000106610 E028 3.7708669 0.0073010285 6.561219e-01 0.8074445677 7 67339797 67339892 96 + 0.641 0.705 0.268
ENSG00000106610 E029 3.6228104 0.0461058539 6.140362e-01 0.7795680699 7 67339893 67340024 132 + 0.614 0.706 0.390
ENSG00000106610 E030 0.1308682 0.0311079616 3.724928e-01   7 67362881 67362950 70 + 0.000 0.136 9.361