ENSG00000106355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409292 ENSG00000106355 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM5 protein_coding protein_coding 109.2298 62.73817 125.9295 3.100899 6.071981 1.005086 55.718860 34.938508 59.899453 3.5774053 5.5982811 0.7775528 0.51937083 0.55430000 0.47350000 -0.080800000 0.61603950 0.01322562   FALSE
ENST00000409909 ENSG00000106355 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM5 protein_coding protein_coding 109.2298 62.73817 125.9295 3.100899 6.071981 1.005086 15.749031 4.945337 19.515456 0.5743027 1.9441997 1.9783011 0.13576250 0.08013333 0.15730000 0.077166667 0.19185055 0.01322562   FALSE
ENST00000409987 ENSG00000106355 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM5 protein_coding protein_coding 109.2298 62.73817 125.9295 3.100899 6.071981 1.005086 7.926607 6.305511 5.754355 0.9434378 0.6961478 -0.1317403 0.07433750 0.09973333 0.04540000 -0.054333333 0.01322562 0.01322562   FALSE
ENST00000450169 ENSG00000106355 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM5 protein_coding protein_coding 109.2298 62.73817 125.9295 3.100899 6.071981 1.005086 7.933984 2.260962 11.206202 0.5424675 0.2760055 2.3042091 0.06697917 0.03540000 0.08943333 0.054033333 0.03252274 0.01322562   FALSE
MSTRG.29683.4 ENSG00000106355 HEK293_OSMI2_6hA HEK293_TMG_6hB LSM5 protein_coding   109.2298 62.73817 125.9295 3.100899 6.071981 1.005086 17.042580 11.438089 22.562246 1.8144469 1.9013588 0.9794432 0.15826250 0.18390000 0.17866667 -0.005233333 1.00000000 0.01322562   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106355 E001 185.188183 0.0317004278 2.080077e-04 2.762207e-03 7 32485338 32486804 1467 - 2.341 2.003 -1.131
ENSG00000106355 E002 73.395704 0.0013195461 7.789160e-12 6.821962e-10 7 32486805 32486867 63 - 1.943 1.594 -1.179
ENSG00000106355 E003 126.399253 0.0004395455 2.569817e-09 1.378440e-07 7 32486868 32487028 161 - 2.148 1.934 -0.717
ENSG00000106355 E004 63.075970 0.0025545285 3.950848e-02 1.534816e-01 7 32487029 32487034 6 - 1.821 1.709 -0.377
ENSG00000106355 E005 59.868566 0.0007987434 1.680940e-01 3.880408e-01 7 32487035 32487039 5 - 1.787 1.717 -0.236
ENSG00000106355 E006 135.481505 0.0061724083 7.578499e-01 8.712983e-01 7 32487040 32487062 23 - 2.120 2.099 -0.073
ENSG00000106355 E007 119.833901 0.0088520467 9.195318e-01 9.619857e-01 7 32487063 32487064 2 - 2.064 2.052 -0.043
ENSG00000106355 E008 900.747637 0.0015352902 7.294698e-06 1.595374e-04 7 32487065 32487293 229 - 2.906 2.985 0.262
ENSG00000106355 E009 15.914692 0.0589600851 3.662096e-01 6.009150e-01 7 32487294 32487684 391 - 1.244 1.124 -0.425
ENSG00000106355 E010 834.649843 0.0001412233 1.114053e-03 1.077709e-02 7 32487685 32487757 73 - 2.890 2.928 0.125
ENSG00000106355 E011 63.029237 0.0658699294 1.929080e-01 4.206823e-01 7 32487758 32488624 867 - 1.827 1.698 -0.436
ENSG00000106355 E012 589.929852 0.0005026836 1.912547e-01 4.184363e-01 7 32488625 32488652 28 - 2.761 2.737 -0.081
ENSG00000106355 E013 8.747667 0.0032383827 7.664896e-01 8.764962e-01 7 32489234 32489248 15 - 0.963 0.995 0.117
ENSG00000106355 E014 694.683951 0.0002060918 7.213943e-01 8.490411e-01 7 32489249 32489344 96 - 2.823 2.826 0.010
ENSG00000106355 E015 4.207878 0.0160128131 8.636553e-01 9.324246e-01 7 32489464 32489600 137 - 0.677 0.701 0.099
ENSG00000106355 E016 9.322692 0.0046051233 9.956474e-01 9.994253e-01 7 32490025 32490130 106 - 0.996 0.995 -0.002
ENSG00000106355 E017 17.573193 0.0022775041 1.302382e-01 3.321813e-01 7 32490131 32490319 189 - 1.198 1.322 0.439
ENSG00000106355 E018 381.962790 0.0007117322 2.252283e-02 1.043115e-01 7 32490320 32490591 272 - 2.548 2.595 0.157
ENSG00000106355 E019 5.548286 0.3731204338 6.174097e-01 7.820335e-01 7 32490592 32490759 168 - 0.790 0.812 0.085
ENSG00000106355 E020 2.288646 0.0264327519 6.520255e-01 8.047686e-01 7 32490760 32490863 104 - 0.525 0.444 -0.400
ENSG00000106355 E021 2.438842 0.0757882192 7.443988e-01 8.633088e-01 7 32494856 32494921 66 - 0.493 0.566 0.344
ENSG00000106355 E022 3.805055 0.0073136040 6.975227e-01 8.339417e-01 7 32494991 32495229 239 - 0.677 0.614 -0.267
ENSG00000106355 E023 5.786010 0.0662384524 6.139958e-01 7.795409e-01 7 32495230 32495283 54 - 0.776 0.860 0.329