ENSG00000106211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248553 ENSG00000106211 HEK293_OSMI2_6hA HEK293_TMG_6hB HSPB1 protein_coding protein_coding 125.7032 188.4117 34.72558 43.19195 2.712433 -2.439479 39.314574 72.40696 3.145615 18.723767 0.04445701 -4.520334 0.23778333 0.37786667 0.09180000 -0.28606667 1.236279e-16 1.077032e-35 FALSE TRUE
ENST00000429938 ENSG00000106211 HEK293_OSMI2_6hA HEK293_TMG_6hB HSPB1 protein_coding protein_coding 125.7032 188.4117 34.72558 43.19195 2.712433 -2.439479 5.773013 10.60222 3.040069 3.771644 1.47855537 -1.798812 0.05230417 0.05236667 0.09353333 0.04116667 8.970368e-01 1.077032e-35   FALSE
ENST00000674965 ENSG00000106211 HEK293_OSMI2_6hA HEK293_TMG_6hB HSPB1 protein_coding nonsense_mediated_decay 125.7032 188.4117 34.72558 43.19195 2.712433 -2.439479 1.008251 0.00000 2.512008 0.000000 0.07631903 7.978429 0.02097083 0.00000000 0.07343333 0.07343333 1.077032e-35 1.077032e-35 TRUE TRUE
MSTRG.30096.1 ENSG00000106211 HEK293_OSMI2_6hA HEK293_TMG_6hB HSPB1 protein_coding   125.7032 188.4117 34.72558 43.19195 2.712433 -2.439479 15.928894 26.04838 2.615956 5.513786 0.41422166 -3.310833 0.11700833 0.13986667 0.07520000 -0.06466667 3.635336e-02 1.077032e-35 FALSE TRUE
MSTRG.30096.19 ENSG00000106211 HEK293_OSMI2_6hA HEK293_TMG_6hB HSPB1 protein_coding   125.7032 188.4117 34.72558 43.19195 2.712433 -2.439479 58.707067 71.83639 21.343480 14.610820 3.99136528 -1.750444 0.52670833 0.38833333 0.60470000 0.21636667 1.933115e-01 1.077032e-35   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106211 E001 57.1442197 0.0006807566 9.206215e-10 5.419158e-08 7 76302518 76302672 155 + 0.975 1.636 2.323
ENSG00000106211 E002 60.4182823 0.0009466010 5.848472e-12 5.263407e-10 7 76302673 76302687 15 + 0.890 1.662 2.734
ENSG00000106211 E003 92.5181981 0.0008720313 2.611951e-19 6.887723e-17 7 76302688 76302698 11 + 0.975 1.847 3.038
ENSG00000106211 E004 454.7697957 0.7460362031 5.940454e-02 2.014710e-01 7 76302699 76303076 378 + 1.847 2.524 2.268
ENSG00000106211 E005 0.7677130 0.0176826182 6.808792e-01   7 76303077 76303080 4 + 0.000 0.208 12.233
ENSG00000106211 E006 0.4341107 0.0225130093 1.000000e+00   7 76303081 76303111 31 + 0.000 0.136 11.426
ENSG00000106211 E007 0.6479912 0.4318153953 1.000000e+00   7 76303112 76303204 93 + 0.000 0.174 10.984
ENSG00000106211 E008 0.6479912 0.4318153953 1.000000e+00   7 76303205 76303227 23 + 0.000 0.174 10.984
ENSG00000106211 E009 0.6479912 0.4318153953 1.000000e+00   7 76303228 76303279 52 + 0.000 0.174 10.984
ENSG00000106211 E010 0.6479912 0.4318153953 1.000000e+00   7 76303280 76303415 136 + 0.000 0.174 10.984
ENSG00000106211 E011 0.3751086 0.0332466495 1.000000e+00   7 76303416 76303471 56 + 0.000 0.096 10.722
ENSG00000106211 E012 9.7491531 0.0094167060 3.035991e-01 5.441558e-01 7 76303472 76303576 105 + 0.975 0.855 -0.454
ENSG00000106211 E013 76.6889822 0.0212656003 1.661204e-02 8.401900e-02 7 76303577 76303656 80 + 1.871 1.684 -0.632
ENSG00000106211 E014 97.0962377 0.0077662238 2.060486e-03 1.746389e-02 7 76303657 76303697 41 + 1.956 1.789 -0.564
ENSG00000106211 E015 117.0754714 0.0008460981 3.465033e-02 1.406595e-01 7 76303698 76303727 30 + 1.953 1.887 -0.221
ENSG00000106211 E016 181.2066836 0.0006013506 3.480812e-02 1.410826e-01 7 76303728 76303761 34 + 2.123 2.077 -0.155
ENSG00000106211 E017 170.0683269 0.0003276041 3.411825e-02 1.391783e-01 7 76303762 76303776 15 + 2.097 2.050 -0.159
ENSG00000106211 E018 204.0319354 0.0051279326 2.511745e-07 8.436551e-06 7 76303777 76303801 25 + 2.309 2.100 -0.699
ENSG00000106211 E019 419.2836457 0.0002071035 3.205893e-01 5.602185e-01 7 76303802 76303806 5 + 2.439 2.449 0.034
ENSG00000106211 E020 677.7665455 0.0001381543 3.245822e-02 1.345839e-01 7 76303807 76303844 38 + 2.661 2.655 -0.017
ENSG00000106211 E021 619.7309910 0.0003094873 5.511907e-02 1.916208e-01 7 76303845 76303865 21 + 2.621 2.616 -0.018
ENSG00000106211 E022 2.3756254 0.0097162484 5.173331e-01 7.132220e-01 7 76303866 76303882 17 + 0.266 0.435 1.029
ENSG00000106211 E023 0.0000000       7 76303883 76303888 6 +      
ENSG00000106211 E024 3.0372361 0.0077910511 2.580134e-01 4.967468e-01 7 76303889 76303983 95 + 0.641 0.454 -0.872
ENSG00000106211 E025 1076.5840131 0.0034639583 1.726249e-01 3.939672e-01 7 76303984 76304295 312 + 2.853 2.853 0.001