ENSG00000106105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389266 ENSG00000106105 HEK293_OSMI2_6hA HEK293_TMG_6hB GARS1 protein_coding protein_coding 149.9439 136.1492 168.252 40.63328 6.719429 0.3054152 88.630331 85.537453 86.935973 22.408313 5.647163 0.0233943 0.6081083 0.65530000 0.52096667 -0.134333333 5.642100e-01 2.050367e-22 FALSE TRUE
ENST00000674851 ENSG00000106105 HEK293_OSMI2_6hA HEK293_TMG_6hB GARS1 protein_coding protein_coding 149.9439 136.1492 168.252 40.63328 6.719429 0.3054152 14.572145 0.000000 52.363413 0.000000 13.333422 12.3546189 0.0878000 0.00000000 0.30740000 0.307400000 2.050367e-22 2.050367e-22 FALSE TRUE
ENST00000675051 ENSG00000106105 HEK293_OSMI2_6hA HEK293_TMG_6hB GARS1 protein_coding protein_coding 149.9439 136.1492 168.252 40.63328 6.719429 0.3054152 9.798129 9.224196 10.189122 9.224196 6.991252 0.1433868 0.0556750 0.04956667 0.05953333 0.009966667 6.637532e-01 2.050367e-22 FALSE TRUE
MSTRG.29678.32 ENSG00000106105 HEK293_OSMI2_6hA HEK293_TMG_6hB GARS1 protein_coding   149.9439 136.1492 168.252 40.63328 6.719429 0.3054152 25.839010 31.532319 8.498842 11.415449 1.018684 -1.8902540 0.1710667 0.21536667 0.05116667 -0.164200000 1.077177e-05 2.050367e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106105 E001 0.1308682 0.0326491905 4.597975e-01   7 30580533 30580590 58 + 0.000 0.129 8.762
ENSG00000106105 E002 0.0000000       7 30593909 30594017 109 +      
ENSG00000106105 E003 1.0414035 0.0432743473 2.470238e-01   7 30594832 30594832 1 + 0.204 0.435 1.525
ENSG00000106105 E004 1.1722716 0.0642928378 1.664496e-01   7 30594833 30594837 5 + 0.204 0.485 1.780
ENSG00000106105 E005 1.7795645 0.1800277451 3.385361e-01 5.766935e-01 7 30594838 30594842 5 + 0.340 0.567 1.176
ENSG00000106105 E006 8.7624817 0.0990937131 8.170257e-03 5.011187e-02 7 30594843 30594858 16 + 0.709 1.186 1.800
ENSG00000106105 E007 14.3793804 0.1416166201 5.706904e-03 3.827425e-02 7 30594859 30594863 5 + 0.855 1.397 1.957
ENSG00000106105 E008 29.6737136 0.3986526745 6.747716e-02 2.193983e-01 7 30594864 30594877 14 + 1.193 1.680 1.684
ENSG00000106105 E009 30.0966780 0.3947191301 6.446420e-02 2.127092e-01 7 30594878 30594881 4 + 1.193 1.688 1.711
ENSG00000106105 E010 43.1960151 0.5505328561 1.287392e-01 3.298251e-01 7 30594882 30594888 7 + 1.381 1.826 1.518
ENSG00000106105 E011 59.6236001 0.6941754624 1.929466e-01 4.207158e-01 7 30594889 30594893 5 + 1.555 1.947 1.326
ENSG00000106105 E012 79.8780953 0.7825650441 2.126512e-01 4.448462e-01 7 30594894 30594896 3 + 1.680 2.072 1.321
ENSG00000106105 E013 119.2313482 1.1250150057 2.425304e-01 4.793953e-01 7 30594897 30594905 9 + 1.806 2.263 1.532
ENSG00000106105 E014 126.2824637 1.1420019045 2.405382e-01 4.771802e-01 7 30594906 30594907 2 + 1.826 2.290 1.555
ENSG00000106105 E015 133.6223961 1.1586199640 2.377899e-01 4.740057e-01 7 30594908 30594913 6 + 1.844 2.317 1.584
ENSG00000106105 E016 162.4643742 1.2304859207 2.493862e-01 4.871913e-01 7 30594914 30594939 26 + 1.929 2.401 1.579
ENSG00000106105 E017 169.1861408 1.2465617042 2.548615e-01 4.934259e-01 7 30594940 30594952 13 + 1.949 2.417 1.567
ENSG00000106105 E018 388.1961617 1.5928223618 3.975401e-01 6.263899e-01 7 30594953 30595107 155 + 2.393 2.739 1.150
ENSG00000106105 E019 255.8832503 1.5014759427 4.572333e-01 6.712141e-01 7 30595108 30595143 36 + 2.271 2.526 0.851
ENSG00000106105 E020 0.4868358 0.3092499845 6.548016e-01   7 30595796 30595823 28 + 0.207 0.127 -0.846
ENSG00000106105 E021 8.2614854 0.0034864653 8.894802e-01 9.464404e-01 7 30595824 30595933 110 + 0.959 0.985 0.099
ENSG00000106105 E022 587.8155354 0.0168739940 4.429377e-01 6.607085e-01 7 30598796 30598897 102 + 2.732 2.808 0.253
ENSG00000106105 E023 0.0000000       7 30599424 30599545 122 +      
ENSG00000106105 E024 785.9575233 0.0008643950 2.160243e-04 2.852492e-03 7 30599947 30600049 103 + 2.909 2.883 -0.086
ENSG00000106105 E025 698.5645563 0.0001569114 3.809061e-07 1.216829e-05 7 30601059 30601128 70 + 2.858 2.831 -0.090
ENSG00000106105 E026 837.3887068 0.0019871455 3.118621e-03 2.412818e-02 7 30601129 30601200 72 + 2.938 2.904 -0.114
ENSG00000106105 E027 2.4469097 0.0089698965 4.855342e-01 6.909588e-01 7 30601201 30601224 24 + 0.568 0.489 -0.375
ENSG00000106105 E028 1.2429203 0.0400506069 5.608784e-01   7 30601225 30602341 1117 + 0.397 0.310 -0.524
ENSG00000106105 E029 2.5917572 0.0086860895 3.601282e-01 5.958153e-01 7 30602342 30603033 692 + 0.602 0.489 -0.526
ENSG00000106105 E030 896.2632226 0.0001577211 2.012287e-20 6.270324e-18 7 30603034 30603122 89 + 2.987 2.912 -0.248
ENSG00000106105 E031 2.0499131 0.0150780721 5.288233e-01 7.211914e-01 7 30603123 30603495 373 + 0.398 0.536 0.700
ENSG00000106105 E032 781.7544539 0.0001091603 6.723830e-12 5.972076e-10 7 30603496 30603572 77 + 2.914 2.870 -0.147
ENSG00000106105 E033 3.6518372 0.2759941293 1.070079e-01 2.939821e-01 7 30603573 30604989 1417 + 0.811 0.386 -1.935
ENSG00000106105 E034 8.0890563 0.0042724658 2.121807e-01 4.443162e-01 7 30604990 30606325 1336 + 1.000 0.900 -0.376
ENSG00000106105 E035 3.3175273 0.2694875785 4.320583e-01 6.527862e-01 7 30606326 30606397 72 + 0.532 0.721 0.825
ENSG00000106105 E036 7.7305021 0.0041937483 3.619691e-06 8.713065e-05 7 30606398 30608407 2010 + 1.123 0.577 -2.146
ENSG00000106105 E037 2.1842635 0.0093814980 3.652019e-02 1.456473e-01 7 30608408 30608483 76 + 0.633 0.310 -1.665
ENSG00000106105 E038 6.9716027 0.0042426567 5.354805e-02 1.879910e-01 7 30608484 30609584 1101 + 0.986 0.793 -0.740
ENSG00000106105 E039 1057.6365107 0.0004086508 5.011099e-06 1.153585e-04 7 30609585 30609730 146 + 3.033 3.015 -0.058
ENSG00000106105 E040 1055.5264884 0.0016860528 7.739673e-03 4.808746e-02 7 30612096 30612245 150 + 3.027 3.018 -0.028
ENSG00000106105 E041 6.1703010 0.0244791656 4.551729e-01 6.696211e-01 7 30613445 30613597 153 + 0.883 0.815 -0.261
ENSG00000106105 E042 1.0835299 0.0149319335 6.700765e-01   7 30614242 30614255 14 + 0.278 0.378 0.626
ENSG00000106105 E043 1.0725712 0.0153787590 7.444569e-01   7 30614256 30614285 30 + 0.342 0.310 -0.205
ENSG00000106105 E044 395.5882116 0.0019170710 1.083442e-02 6.166564e-02 7 30615896 30615897 2 + 2.607 2.585 -0.073
ENSG00000106105 E045 958.5585481 0.0008174316 1.072054e-01 2.943564e-01 7 30615898 30616058 161 + 2.972 2.991 0.064
ENSG00000106105 E046 1096.1259711 0.0022434701 3.460128e-01 5.835826e-01 7 30617114 30617278 165 + 3.025 3.055 0.100
ENSG00000106105 E047 1170.8355009 0.0038988422 9.990497e-02 2.815680e-01 7 30621393 30621500 108 + 3.068 3.068 -0.001
ENSG00000106105 E048 21.4538012 0.0021106811 9.850883e-04 9.801421e-03 7 30621501 30622316 816 + 1.438 1.229 -0.727
ENSG00000106105 E049 1444.2797828 0.0022463012 7.231558e-02 2.294354e-01 7 30622317 30622462 146 + 3.156 3.162 0.022
ENSG00000106105 E050 6.6269561 0.0042191682 2.102877e-01 4.421568e-01 7 30622463 30623013 551 + 0.929 0.817 -0.432
ENSG00000106105 E051 1092.3051066 0.0018063152 2.408079e-02 1.093325e-01 7 30626234 30626319 86 + 3.038 3.037 -0.001
ENSG00000106105 E052 3.7612342 0.0065904936 1.166559e-03 1.117305e-02 7 30627057 30627190 134 + 0.845 0.378 -2.113
ENSG00000106105 E053 7.5935602 0.0418419418 3.446141e-02 1.401242e-01 7 30627380 30628543 1164 + 1.050 0.764 -1.088
ENSG00000106105 E054 2.1833701 0.0171771375 1.592681e-01 3.756510e-01 7 30628544 30628559 16 + 0.343 0.616 1.380
ENSG00000106105 E055 1147.1210899 0.0023111624 5.120255e-01 7.094787e-01 7 30628560 30628669 110 + 3.024 3.094 0.233
ENSG00000106105 E056 107.3696456 0.0722612056 9.107904e-04 9.184867e-03 7 30628670 30631447 2778 + 2.190 1.740 -1.514
ENSG00000106105 E057 1092.3029106 0.0057989290 3.386864e-01 5.768402e-01 7 30631448 30631541 94 + 2.988 3.087 0.330
ENSG00000106105 E058 5.6370374 0.0056830376 5.762224e-02 1.974492e-01 7 30631542 30631559 18 + 0.898 0.683 -0.852
ENSG00000106105 E059 33.6373821 0.0344366888 3.433953e-03 2.595545e-02 7 30631560 30632246 687 + 1.656 1.352 -1.044
ENSG00000106105 E060 1675.5377216 0.0015979578 5.007281e-02 1.798533e-01 7 30632247 30632437 191 + 3.178 3.270 0.306
ENSG00000106105 E061 1123.7825084 0.0009614739 6.938158e-04 7.391837e-03 7 30633735 30634033 299 + 2.995 3.106 0.371