ENSG00000106100

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222823 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding protein_coding 2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.92771047 1.54191526 0.51684183 0.38474044 0.31312356 -1.5586080 0.33967917 0.38140000 0.2338667 -0.147533333 0.780563602 0.001195858 FALSE TRUE
ENST00000419799 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding protein_coding 2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.17626424 0.73289108 0.25697087 0.37111075 0.25697087 -1.4764684 0.04400000 0.16220000 0.1030333 -0.059166667 0.798350440 0.001195858   FALSE
ENST00000434755 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding nonsense_mediated_decay 2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.19301786 0.17408503 0.32932343 0.07736397 0.08879782 0.8822887 0.08826250 0.05343333 0.1760333 0.122600000 0.397945439 0.001195858 TRUE TRUE
MSTRG.29665.10 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding   2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.05651924 0.00000000 0.11210200 0.00000000 0.11210200 3.6100149 0.02927917 0.00000000 0.0623000 0.062300000 0.785890818 0.001195858 FALSE TRUE
MSTRG.29665.3 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding   2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.14103574 0.12235225 0.08011407 0.02720337 0.03296960 -0.5545584 0.06532083 0.03503333 0.0433000 0.008266667 0.978177433 0.001195858 TRUE TRUE
MSTRG.29665.4 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding   2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.27589105 0.22841397 0.24555437 0.22841397 0.24555437 0.1001615 0.13037500 0.08350000 0.1365000 0.053000000 0.976092097 0.001195858 FALSE TRUE
MSTRG.29665.5 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding   2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.31454612 0.50617853 0.00000000 0.12624940 0.00000000 -5.6897982 0.10915417 0.13680000 0.0000000 -0.136800000 0.001195858 0.001195858 FALSE TRUE
MSTRG.29665.9 ENSG00000106100 HEK293_OSMI2_6hA HEK293_TMG_6hB NOD1 protein_coding   2.626845 3.930085 2.014541 0.5993227 0.2400848 -0.9606319 0.07130940 0.09462195 0.31538043 0.09462195 0.19045831 1.6369419 0.03180000 0.02053333 0.1638000 0.143266667 0.633181667 0.001195858 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106100 E001 0.3559677 0.908235322 0.197614730   7 30423509 30423913 405 - 0.302 0.000 -11.606
ENSG00000106100 E002 0.3393995 0.026742274 0.054978815   7 30423914 30424088 175 - 0.293 0.000 -15.192
ENSG00000106100 E003 0.5283420 0.601364655 0.323054592   7 30424089 30424262 174 - 0.300 0.086 -2.179
ENSG00000106100 E004 0.8206259 0.069499998 0.178677032   7 30424263 30424526 264 - 0.389 0.156 -1.748
ENSG00000106100 E005 0.4646582 0.021768165 0.921956898   7 30424527 30424529 3 - 0.171 0.156 -0.153
ENSG00000106100 E006 0.5955263 0.020728666 0.847136424   7 30424530 30424533 4 - 0.171 0.217 0.430
ENSG00000106100 E007 48.7579028 0.218741402 0.042530275 0.161327204 7 30424534 30425208 675 - 1.388 1.744 1.214
ENSG00000106100 E008 42.2624809 0.001001729 0.000491186 0.005593795 7 30425209 30425710 502 - 1.423 1.653 0.789
ENSG00000106100 E009 1.2650278 0.959208644 0.525126792   7 30428504 30428609 106 - 0.554 0.164 -2.488
ENSG00000106100 E010 20.3351783 0.002192351 0.537639385 0.727442840 7 30429374 30429457 84 - 1.239 1.308 0.240
ENSG00000106100 E011 22.1465436 0.001966995 0.600822073 0.770761367 7 30433096 30433179 84 - 1.345 1.321 -0.084
ENSG00000106100 E012 0.6182515 0.019420352 0.847712923   7 30433180 30433414 235 - 0.170 0.217 0.434
ENSG00000106100 E013 20.6552958 0.002269158 0.689651493 0.828800911 7 30435998 30436081 84 - 1.263 1.312 0.173
ENSG00000106100 E014 16.1779150 0.010353851 0.469919107 0.680014251 7 30437573 30437656 84 - 1.228 1.180 -0.167
ENSG00000106100 E015 20.2592468 0.040522816 0.298864395 0.539334235 7 30446141 30446224 84 - 1.356 1.268 -0.305
ENSG00000106100 E016 1.4144869 0.058441467 0.821199218 0.908708044 7 30446225 30446966 742 - 0.387 0.361 -0.151
ENSG00000106100 E017 11.9203890 0.003410376 0.563975432 0.746099134 7 30446967 30447014 48 - 1.115 1.072 -0.153
ENSG00000106100 E018 13.1765923 0.002674331 0.202493873 0.432734556 7 30447015 30447050 36 - 1.188 1.081 -0.385
ENSG00000106100 E019 5.3871669 0.046792677 0.171009213 0.391885142 7 30447051 30447148 98 - 0.914 0.720 -0.762
ENSG00000106100 E020 4.6757495 0.108757720 0.365442755 0.600293033 7 30447149 30447977 829 - 0.531 0.784 1.082
ENSG00000106100 E021 13.2916847 0.012031241 0.554056066 0.739150681 7 30448298 30448381 84 - 1.159 1.105 -0.195
ENSG00000106100 E022 30.1415573 0.058862891 0.122780876 0.320134963 7 30451216 30451718 503 - 1.327 1.510 0.630
ENSG00000106100 E023 11.0694315 0.063082310 0.286538885 0.527220745 7 30451719 30451853 135 - 0.934 1.096 0.594
ENSG00000106100 E024 27.4500386 0.232722937 0.467840510 0.678602301 7 30451854 30452378 525 - 1.378 1.439 0.211
ENSG00000106100 E025 15.6984814 0.040078809 0.724051321 0.850603057 7 30452379 30452663 285 - 1.169 1.207 0.134
ENSG00000106100 E026 6.1433829 0.004572115 0.206999684 0.438183949 7 30452664 30452697 34 - 0.685 0.875 0.757
ENSG00000106100 E027 9.0191536 0.003750025 0.384393720 0.615949035 7 30452698 30452833 136 - 0.888 1.004 0.435
ENSG00000106100 E028 19.7995681 0.011649281 0.174122982 0.396043302 7 30452834 30453040 207 - 1.186 1.326 0.492
ENSG00000106100 E029 22.8300522 0.001943514 0.057701143 0.197651757 7 30455137 30455311 175 - 1.423 1.298 -0.434
ENSG00000106100 E030 12.8143614 0.067036959 0.096536206 0.275711276 7 30456721 30456742 22 - 1.231 1.025 -0.740
ENSG00000106100 E031 14.8883599 0.057008135 0.091414456 0.266308020 7 30456743 30456784 42 - 1.287 1.091 -0.697
ENSG00000106100 E032 24.0044927 0.078328898 0.248876174 0.486649227 7 30456785 30457042 258 - 1.429 1.322 -0.372
ENSG00000106100 E033 10.7337784 0.063545659 0.091007818 0.265529352 7 30459152 30459240 89 - 1.160 0.957 -0.739
ENSG00000106100 E034 17.3540517 0.002601784 0.018792426 0.091706498 7 30459901 30460041 141 - 1.345 1.166 -0.632
ENSG00000106100 E035 1.5835372 0.011828365 0.517590909 0.713337237 7 30463536 30463608 73 - 0.466 0.361 -0.568
ENSG00000106100 E036 14.3369836 0.011122790 0.265778495 0.505230829 7 30463609 30463698 90 - 1.215 1.125 -0.320
ENSG00000106100 E037 0.1723744 0.032002673 1.000000000   7 30463986 30464061 76 - 0.000 0.085 11.672
ENSG00000106100 E038 0.3040503 0.024441170 0.055709951   7 30475848 30475988 141 - 0.292 0.000 -15.195
ENSG00000106100 E039 11.6657357 0.016913573 0.554556820 0.739501006 7 30478606 30478806 201 - 1.098 1.057 -0.151