ENSG00000106089

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222812 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding protein_coding 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 4.2527810 5.4663314 2.3490760 0.27787600 0.17120670 -1.2149878 0.32201250 0.30520000 0.29016667 -0.01503333 0.9564390109 0.0006814602 FALSE TRUE
ENST00000395156 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding protein_coding 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 0.3209371 0.9259400 0.0000000 0.35426138 0.00000000 -6.5483441 0.01865000 0.05170000 0.00000000 -0.05170000 0.0006814602 0.0006814602 FALSE TRUE
ENST00000461441 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding retained_intron 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 0.8728057 1.5140792 1.0053931 0.62419418 0.06402521 -0.5858995 0.06815000 0.08053333 0.12403333 0.04350000 0.6818205268 0.0006814602 FALSE FALSE
ENST00000462135 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding retained_intron 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 0.9387937 0.8059894 0.6585118 0.01190825 0.26763452 -0.2875973 0.07691250 0.04530000 0.08366667 0.03836667 0.7847763383 0.0006814602 FALSE TRUE
ENST00000484736 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding processed_transcript 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 0.8660003 0.9194399 0.3012842 0.54005860 0.30128417 -1.5781293 0.05743750 0.04813333 0.03176667 -0.01636667 0.8020808887 0.0006814602   FALSE
ENST00000491427 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding retained_intron 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 0.8147090 0.8609552 0.2917916 0.32603131 0.22309658 -1.5290457 0.05981250 0.04666667 0.03203333 -0.01463333 0.8295473596 0.0006814602 FALSE TRUE
ENST00000491645 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding processed_transcript 13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 1.2792355 1.4251793 1.1174110 0.44116923 0.17483868 -0.3482174 0.09927917 0.07720000 0.13490000 0.05770000 0.4779411462 0.0006814602 TRUE FALSE
MSTRG.30044.4 ENSG00000106089 HEK293_OSMI2_6hA HEK293_TMG_6hB STX1A protein_coding   13.29783 18.00862 8.262324 1.444728 0.614658 -1.123124 2.2770011 4.4019002 1.6916699 0.60873359 0.47419032 -1.3744490 0.16995833 0.25360000 0.19940000 -0.05420000 0.8714798293 0.0006814602 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106089 E001 0.3751086 0.0249459103 0.898265035   7 73699206 73699209 4 - 0.000 0.133 8.573
ENSG00000106089 E002 90.8938946 0.0243730030 0.706796097 0.8398010 7 73699210 73699758 549 - 1.837 1.906 0.234
ENSG00000106089 E003 105.7492018 0.0307765136 0.557262207 0.7413298 7 73699759 73700234 476 - 1.885 1.976 0.305
ENSG00000106089 E004 21.9677391 0.0243338016 0.574320088 0.7532281 7 73700235 73700286 52 - 1.222 1.319 0.341
ENSG00000106089 E005 20.8891261 0.0019156229 0.480651669 0.6875307 7 73700287 73700315 29 - 1.207 1.293 0.304
ENSG00000106089 E006 50.4987162 0.0025154077 0.360185408 0.5958648 7 73700316 73700484 169 - 1.665 1.636 -0.100
ENSG00000106089 E007 0.7844689 0.0172095437 0.927454117   7 73700729 73700729 1 - 0.199 0.235 0.302
ENSG00000106089 E008 38.8917538 0.0010355166 0.892448395 0.9478256 7 73700730 73700776 47 - 1.502 1.534 0.109
ENSG00000106089 E009 27.4105681 0.0013005062 0.555061107 0.7398239 7 73700777 73700782 6 - 1.329 1.398 0.242
ENSG00000106089 E010 27.6131377 0.0013561406 0.927125671 0.9656083 7 73700783 73700794 12 - 1.374 1.389 0.053
ENSG00000106089 E011 31.0981601 0.0033124808 0.526636106 0.7195831 7 73700795 73700804 10 - 1.451 1.427 -0.084
ENSG00000106089 E012 37.4006986 0.0035802708 0.235386260 0.4712970 7 73700805 73700826 22 - 1.554 1.495 -0.202
ENSG00000106089 E013 33.8761467 0.0014324139 0.268506242 0.5081862 7 73700827 73700840 14 - 1.510 1.457 -0.181
ENSG00000106089 E014 48.5500093 0.0020657787 0.520492122 0.7152622 7 73700841 73700931 91 - 1.637 1.619 -0.061
ENSG00000106089 E015 12.1390893 0.0171403842 0.003493232 0.0262992 7 73700932 73701210 279 - 1.264 0.959 -1.099
ENSG00000106089 E016 9.6110133 0.1639597181 0.217017617 0.4499087 7 73702537 73702729 193 - 1.085 0.915 -0.629
ENSG00000106089 E017 8.7472701 0.0846995628 0.137280288 0.3433550 7 73702730 73702844 115 - 1.060 0.868 -0.718
ENSG00000106089 E018 67.9093137 0.0019230663 0.928974317 0.9665139 7 73702845 73702982 138 - 1.744 1.770 0.088
ENSG00000106089 E019 32.7098720 0.2377609075 0.533046906 0.7242262 7 73703755 73703762 8 - 1.413 1.470 0.194
ENSG00000106089 E020 47.9757045 0.3011752316 0.325270467 0.5645046 7 73703763 73703828 66 - 1.497 1.649 0.521
ENSG00000106089 E021 2.1584744 0.2012557217 0.299727743 0.5401463 7 73703829 73704055 227 - 0.198 0.504 1.925
ENSG00000106089 E022 35.9466736 0.2018456951 0.332566122 0.5712991 7 73704148 73704179 32 - 1.379 1.527 0.510
ENSG00000106089 E023 42.7819145 0.2846018668 0.378309660 0.6107991 7 73704180 73704256 77 - 1.468 1.597 0.439
ENSG00000106089 E024 6.3210093 0.0173354991 0.929621875 0.9668231 7 73704257 73704349 93 - 0.793 0.826 0.127
ENSG00000106089 E025 44.5456741 0.3588020947 0.544006134 0.7319559 7 73704350 73704423 74 - 1.554 1.597 0.147
ENSG00000106089 E026 1.3271501 0.0160004695 0.876844182   7 73704424 73704496 73 - 0.335 0.318 -0.107
ENSG00000106089 E027 49.9916265 0.0383565594 0.894076770 0.9487297 7 73705150 73705224 75 - 1.648 1.633 -0.051
ENSG00000106089 E028 4.5161420 0.0065008999 0.469531065 0.6797018 7 73705225 73705465 241 - 0.752 0.661 -0.373
ENSG00000106089 E029 4.5291259 0.0060635477 0.883569894 0.9431443 7 73705764 73705880 117 - 0.652 0.694 0.180
ENSG00000106089 E030 53.7900923 0.0008167666 0.088121330 0.2602446 7 73708589 73708688 100 - 1.717 1.648 -0.235
ENSG00000106089 E031 41.8090916 0.0013776321 0.960213935 0.9819554 7 73709045 73709122 78 - 1.540 1.561 0.070
ENSG00000106089 E032 2.2636060 0.0707406817 0.557099204 0.7412059 7 73716581 73716734 154 - 0.522 0.422 -0.502
ENSG00000106089 E033 24.4460084 0.0019228906 0.950025360 0.9770961 7 73719602 73719685 84 - 1.317 1.335 0.063