ENSG00000106025

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222747 ENSG00000106025 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN12 protein_coding protein_coding 21.21807 14.73791 18.19321 2.683367 1.105748 0.3036828 4.030499 1.338983 8.325892 0.2496085 0.3901219 2.6274641 0.2118167 0.09076667 0.4584667 0.3677000 5.142628e-27 5.142628e-27 FALSE TRUE
ENST00000415871 ENSG00000106025 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN12 protein_coding protein_coding 21.21807 14.73791 18.19321 2.683367 1.105748 0.3036828 1.237232 0.000000 2.281937 0.0000000 0.2320993 7.8404237 0.0664750 0.00000000 0.1254333 0.1254333 1.201214e-17 5.142628e-27 FALSE TRUE
MSTRG.30575.10 ENSG00000106025 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN12 protein_coding   21.21807 14.73791 18.19321 2.683367 1.105748 0.3036828 6.368633 7.051579 4.347608 1.5378382 0.3688504 -0.6964544 0.2838208 0.47050000 0.2427333 -0.2277667 1.734370e-02 5.142628e-27   FALSE
MSTRG.30575.9 ENSG00000106025 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN12 protein_coding   21.21807 14.73791 18.19321 2.683367 1.105748 0.3036828 8.306915 5.706647 2.125540 1.1638966 0.9100208 -1.4205681 0.3709167 0.38956667 0.1120333 -0.2775333 1.041447e-02 5.142628e-27   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000106025 E001 106.221195 0.0005136212 6.152260e-24 2.816160e-21 7 120787320 120788321 1002 - 2.108 1.696 -1.387
ENSG00000106025 E002 32.979402 0.0021793777 4.669594e-17 9.351468e-15 7 120788322 120788373 52 - 1.648 0.922 -2.564
ENSG00000106025 E003 112.880290 0.0005188720 1.033715e-45 2.659827e-42 7 120788374 120788897 524 - 2.160 1.544 -2.080
ENSG00000106025 E004 47.377457 0.0008988578 3.232538e-16 5.742252e-14 7 120806549 120806692 144 - 1.777 1.244 -1.832
ENSG00000106025 E005 27.214145 0.0015520381 2.227424e-11 1.808163e-09 7 120810463 120810488 26 - 1.552 0.967 -2.066
ENSG00000106025 E006 37.144537 0.0012248342 1.780997e-13 2.109165e-11 7 120810489 120810570 82 - 1.676 1.127 -1.903
ENSG00000106025 E007 2.022778 0.0564201674 5.884797e-01 7.626654e-01 7 120814005 120814247 243 - 0.485 0.377 -0.575
ENSG00000106025 E008 24.691021 0.0364620986 1.344015e-04 1.913360e-03 7 120815729 120815750 22 - 1.495 0.996 -1.766
ENSG00000106025 E009 30.412883 0.0045170538 5.559985e-13 5.979819e-11 7 120815751 120815803 53 - 1.606 0.946 -2.331
ENSG00000106025 E010 50.615119 0.0009608222 7.048775e-17 1.375913e-14 7 120838777 120838912 136 - 1.806 1.277 -1.814
ENSG00000106025 E011 35.553376 0.0014328872 2.915348e-10 1.871808e-08 7 120840027 120840109 83 - 1.646 1.183 -1.604
ENSG00000106025 E012 87.133945 0.0004787915 2.773399e-53 1.095319e-49 7 120855111 120855381 271 - 1.644 2.205 1.889
ENSG00000106025 E013 140.908114 0.0005227312 2.000583e-50 7.228615e-47 7 120856698 120856833 136 - 1.935 2.356 1.408
ENSG00000106025 E014 2.265733 0.0186628960 8.332710e-01 9.156118e-01 7 120857039 120857085 47 - 0.483 0.517 0.165
ENSG00000106025 E015 2.389774 0.0121208283 6.178082e-01 7.823049e-01 7 120857086 120857199 114 - 0.543 0.453 -0.442
ENSG00000106025 E016 2.688984 0.0136681716 1.995199e-03 1.703180e-02 7 120857233 120857353 121 - 0.329 0.813 2.283
ENSG00000106025 E017 103.456946 0.0003971926 5.451176e-44 1.218072e-40 7 120857820 120857988 169 - 1.781 2.239 1.537
ENSG00000106025 E018 16.505194 0.0019682064 1.789571e-05 3.478830e-04 7 120857989 120858144 156 - 1.066 1.419 1.246
ENSG00000106025 E019 15.261930 0.0024422177 8.948932e-11 6.412382e-09 7 120858204 120858233 30 - 0.916 1.476 1.996
ENSG00000106025 E020 20.573528 0.0025023689 3.024038e-19 7.912962e-17 7 120858234 120858402 169 - 0.940 1.641 2.471