ENSG00000105993

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262177 ENSG00000105993 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJB6 protein_coding protein_coding 99.4104 71.45482 129.665 10.28857 6.361017 0.8595952 48.732657 51.223921 52.78550 6.2565915 1.826391 0.0433157 0.5326875 0.72200000 0.4084000 -0.31360000 7.030676e-10 2.159405e-34 FALSE TRUE
ENST00000417758 ENSG00000105993 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJB6 protein_coding protein_coding 99.4104 71.45482 129.665 10.28857 6.361017 0.8595952 6.184013 1.066667 13.32809 0.3041675 1.590477 3.6309083 0.0494125 0.01443333 0.1021000 0.08766667 5.118897e-09 2.159405e-34 FALSE FALSE
ENST00000429029 ENSG00000105993 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJB6 protein_coding protein_coding 99.4104 71.45482 129.665 10.28857 6.361017 0.8595952 24.042692 13.142712 32.40992 3.1961284 1.145792 1.3015201 0.2350542 0.17800000 0.2504333 0.07243333 3.454303e-01 2.159405e-34 FALSE TRUE
ENST00000488001 ENSG00000105993 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJB6 protein_coding processed_transcript 99.4104 71.45482 129.665 10.28857 6.361017 0.8595952 13.996382 0.000000 25.26364 0.0000000 3.237181 11.3034180 0.1119750 0.00000000 0.1944333 0.19443333 2.159405e-34 2.159405e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105993 E001 0.0000000       7 157335381 157335406 26 +      
ENSG00000105993 E002 1.0478208 0.0153787590 3.049082e-01   7 157336362 157336773 412 + 0.391 0.233 -1.039
ENSG00000105993 E003 0.1308682 0.0326491905 4.489628e-01   7 157336966 157337003 38 + 0.000 0.132 10.900
ENSG00000105993 E004 0.7499275 0.0186806883 7.308454e-01   7 157337004 157337009 6 + 0.273 0.233 -0.299
ENSG00000105993 E005 2.1880697 0.0588703663 9.273548e-01 9.657403e-01 7 157337010 157337022 13 + 0.485 0.539 0.260
ENSG00000105993 E006 2.1880697 0.0588703663 9.273548e-01 9.657403e-01 7 157337023 157337023 1 + 0.485 0.539 0.260
ENSG00000105993 E007 3.2358905 0.0561523687 6.268660e-01 7.884247e-01 7 157337024 157337024 1 + 0.655 0.618 -0.161
ENSG00000105993 E008 14.2560649 0.0137553840 1.258252e-01 3.252065e-01 7 157337025 157337045 21 + 1.239 1.127 -0.399
ENSG00000105993 E009 20.2425123 0.0099534220 3.442648e-01 5.818577e-01 7 157337046 157337054 9 + 1.348 1.312 -0.129
ENSG00000105993 E010 131.4132981 0.0004357515 3.092909e-01 5.497781e-01 7 157337055 157337144 90 + 2.114 2.130 0.052
ENSG00000105993 E011 1.5903144 0.0118413094 8.896218e-01 9.464989e-01 7 157337145 157337150 6 + 0.391 0.444 0.287
ENSG00000105993 E012 0.1723744 0.0333468961 4.470399e-01   7 157337525 157337542 18 + 0.000 0.132 10.895
ENSG00000105993 E013 0.1723744 0.0333468961 4.470399e-01   7 157337543 157337560 18 + 0.000 0.132 10.895
ENSG00000105993 E014 0.1723744 0.0333468961 4.470399e-01   7 157337561 157337628 68 + 0.000 0.132 10.895
ENSG00000105993 E015 0.0000000       7 157337629 157337811 183 +      
ENSG00000105993 E016 0.9217543 0.0174413325 4.752645e-01   7 157339821 157340057 237 + 0.336 0.233 -0.720
ENSG00000105993 E017 127.3751296 0.0006972020 1.613735e-01 3.787827e-01 7 157358547 157358572 26 + 2.106 2.107 0.003
ENSG00000105993 E018 227.2555499 0.0009513164 8.490357e-04 8.681871e-03 7 157358573 157358637 65 + 2.375 2.332 -0.145
ENSG00000105993 E019 480.5096956 0.0001878831 6.514116e-18 1.474996e-15 7 157363161 157363270 110 + 2.721 2.625 -0.323
ENSG00000105993 E020 521.9370389 0.0001421989 3.505481e-20 1.064958e-17 7 157366502 157366561 60 + 2.758 2.660 -0.326
ENSG00000105993 E021 444.7646618 0.0001938553 2.069714e-09 1.136756e-07 7 157367373 157367483 111 + 2.671 2.615 -0.187
ENSG00000105993 E022 1.0531700 0.0176138542 6.272986e-01   7 157368608 157368736 129 + 0.273 0.384 0.700
ENSG00000105993 E023 0.7796672 0.0178112219 5.888273e-01   7 157368737 157368800 64 + 0.200 0.316 0.870
ENSG00000105993 E024 2.8191852 0.0088015638 6.793641e-01 8.223244e-01 7 157368801 157368942 142 + 0.524 0.624 0.456
ENSG00000105993 E025 1.1887199 0.0472584387 8.132007e-01   7 157369131 157369251 121 + 0.336 0.317 -0.121
ENSG00000105993 E026 1.2726600 0.0344817271 9.010427e-01   7 157369360 157369475 116 + 0.336 0.385 0.287
ENSG00000105993 E027 0.9747667 0.9267284080 7.665886e-01   7 157370764 157370789 26 + 0.193 0.394 1.399
ENSG00000105993 E028 1.4503836 0.6404587991 3.843105e-01 6.158771e-01 7 157370790 157370868 79 + 0.195 0.549 2.164
ENSG00000105993 E029 1.7190872 0.0121989077 8.912364e-01 9.472483e-01 7 157372147 157372227 81 + 0.391 0.445 0.286
ENSG00000105993 E030 26.4811755 0.0835404817 1.497724e-01 3.619701e-01 7 157378125 157381820 3696 + 1.269 1.577 1.067
ENSG00000105993 E031 4.8480472 0.1001841238 9.865609e-01 9.951355e-01 7 157381821 157381986 166 + 0.733 0.785 0.211
ENSG00000105993 E032 4.3061920 0.0064915801 3.126069e-02 1.311070e-01 7 157381987 157382245 259 + 0.523 0.870 1.457
ENSG00000105993 E033 207.5913436 0.0007856580 3.821647e-02 1.501524e-01 7 157382246 157382248 3 + 2.320 2.312 -0.028
ENSG00000105993 E034 557.9993525 0.0003405132 3.056578e-05 5.486495e-04 7 157382249 157382377 129 + 2.753 2.732 -0.069
ENSG00000105993 E035 4.9733785 0.0060997364 9.047874e-01 9.543625e-01 7 157382378 157382743 366 + 0.754 0.778 0.093
ENSG00000105993 E036 669.8755706 0.0001555682 1.514336e-09 8.540983e-08 7 157384867 157385008 142 + 2.839 2.802 -0.123
ENSG00000105993 E037 445.9797474 0.0001814567 2.986912e-05 5.377359e-04 7 157385541 157385611 71 + 2.657 2.633 -0.080
ENSG00000105993 E038 141.7347458 0.0150444172 4.657946e-04 5.362527e-03 7 157385612 157386324 713 + 2.222 2.049 -0.580
ENSG00000105993 E039 356.9311338 0.0052983191 3.486025e-03 2.625426e-02 7 157409795 157410001 207 + 2.470 2.632 0.540
ENSG00000105993 E040 265.3814540 0.0181190141 9.463508e-06 1.999404e-04 7 157410002 157415529 5528 + 2.225 2.581 1.190
ENSG00000105993 E041 170.6117604 0.0035723755 1.175232e-02 6.545309e-02 7 157416016 157416024 9 + 2.156 2.304 0.493
ENSG00000105993 E042 2077.9163859 0.0010423610 2.274803e-20 7.049522e-18 7 157416025 157417439 1415 + 3.228 3.400 0.571
ENSG00000105993 E043 1.5594070 0.0123846113 6.212171e-01 7.846871e-01 7 157421215 157421249 35 + 0.440 0.384 -0.303