ENSG00000105968

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222690 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding protein_coding 152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 16.82182 8.908212 20.33136 1.9568419 2.0191488 1.18958955 0.11182083 0.0605000 0.13096667 0.07046667 3.808010e-03 5.253167e-19 FALSE FALSE
ENST00000308153 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding protein_coding 152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 12.87219 3.918803 19.31848 0.4663677 0.2815589 2.29856670 0.08564167 0.0276000 0.12536667 0.09776667 5.253167e-19 5.253167e-19 FALSE FALSE
ENST00000349299 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding protein_coding 152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 16.84743 18.388033 16.24406 3.5334825 0.4994467 -0.17875120 0.11011250 0.1258667 0.10560000 -0.02026667 7.386199e-01 5.253167e-19 FALSE FALSE
ENST00000350771 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding protein_coding 152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 71.24318 73.356646 69.18809 9.4315152 3.1400895 -0.08439206 0.46510833 0.5115667 0.44776667 -0.06380000 3.818624e-02 5.253167e-19 FALSE FALSE
ENST00000381124 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding protein_coding 152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 20.41184 25.905131 12.12261 1.5542679 0.3340266 -1.09490419 0.13255833 0.1842000 0.07856667 -0.10563333 2.063245e-07 5.253167e-19 FALSE FALSE
MSTRG.29819.1 ENSG00000105968 HEK293_OSMI2_6hA HEK293_TMG_6hB H2AZ2 protein_coding   152.4478 143.1678 154.4834 17.60506 6.586179 0.1097371 11.44501 8.930592 13.92842 1.0696837 0.9553978 0.64062439 0.07560833 0.0625000 0.08996667 0.02746667 3.926131e-02 5.253167e-19 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105968 E001 0.1614157 0.032736259 5.417564e-01   7 44821208 44821250 43 - 0.110 0.000 -8.030
ENSG00000105968 E002 857.5344085 2.016317937 8.543446e-01 9.272535e-01 7 44826791 44829896 3106 - 2.958 2.896 -0.206
ENSG00000105968 E003 107.4697837 1.373618736 9.711710e-01 9.874223e-01 7 44829897 44830163 267 - 2.139 1.853 -0.961
ENSG00000105968 E004 419.6454797 0.013951909 4.313816e-21 1.442097e-18 7 44831978 44833467 1490 - 2.783 2.274 -1.698
ENSG00000105968 E005 287.4937930 0.006174449 7.960111e-43 1.648549e-39 7 44833468 44834227 760 - 2.631 2.060 -1.907
ENSG00000105968 E006 45.3841940 0.001371038 1.174563e-11 9.993376e-10 7 44834228 44834238 11 - 1.786 1.449 -1.146
ENSG00000105968 E007 48.4116006 0.003828931 2.428848e-09 1.313194e-07 7 44834239 44834256 18 - 1.805 1.493 -1.062
ENSG00000105968 E008 261.5091330 0.004298934 5.994026e-01 7.698290e-01 7 44834257 44834309 53 - 2.380 2.456 0.254
ENSG00000105968 E009 1305.1471345 0.005223341 6.423497e-02 2.122198e-01 7 44834310 44834562 253 - 3.059 3.172 0.376
ENSG00000105968 E010 26.3921159 0.027717023 2.004708e-02 9.604083e-02 7 44834925 44835528 604 - 1.513 1.315 -0.682
ENSG00000105968 E011 1301.2232193 0.008641173 8.843839e-03 5.311847e-02 7 44835529 44835658 130 - 3.035 3.192 0.523
ENSG00000105968 E012 3.6338257 0.058908984 7.757937e-01 8.822463e-01 7 44835659 44835696 38 - 0.620 0.700 0.338
ENSG00000105968 E013 1006.8487651 0.008879853 1.651073e-03 1.467905e-02 7 44840899 44841012 114 - 2.908 3.093 0.616
ENSG00000105968 E014 630.7706161 0.005745724 3.894776e-06 9.288338e-05 7 44843277 44843354 78 - 2.683 2.908 0.750
ENSG00000105968 E015 334.6508144 0.011805391 2.605483e-04 3.327600e-03 7 44847969 44848125 157 - 2.388 2.646 0.859