ENSG00000105835

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222553 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding protein_coding 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 3.571664 0.9750362 5.045182 0.3127824 0.8544001 2.35951453 0.10031667 0.08956667 0.07450000 -0.01506667 8.643241e-01 1.867636e-22 FALSE TRUE
ENST00000489358 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding protein_coding 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 7.195292 0.0000000 14.331246 0.0000000 1.5609101 10.48595470 0.10734583 0.00000000 0.21286667 0.21286667 1.867636e-22 1.867636e-22 FALSE TRUE
ENST00000680129 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding nonsense_mediated_decay 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 4.136732 1.5936511 4.701609 0.3695043 2.3927378 1.55485965 0.11867917 0.16310000 0.06740000 -0.09570000 7.546868e-01 1.867636e-22 FALSE TRUE
ENST00000680152 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding nonsense_mediated_decay 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 1.568855 1.0917727 1.102738 0.5459357 0.5780442 0.01428698 0.09117083 0.08583333 0.01706667 -0.06876667 8.183045e-01 1.867636e-22 TRUE TRUE
ENST00000680823 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding protein_coding 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 2.184018 1.8052609 2.984383 0.9786369 2.9843831 0.72208188 0.08404167 0.14413333 0.04320000 -0.10093333 5.328202e-01 1.867636e-22 FALSE TRUE
ENST00000681878 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding protein_coding 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 2.462075 0.0000000 5.081876 0.0000000 2.5597826 8.99205344 0.05081250 0.00000000 0.07796667 0.07796667 5.090465e-01 1.867636e-22 FALSE TRUE
ENST00000681887 ENSG00000105835 HEK293_OSMI2_6hA HEK293_TMG_6hB NAMPT protein_coding processed_transcript 38.46481 10.33215 66.9403 2.478859 2.934058 2.694554 12.317824 3.2900829 25.725758 0.5432522 0.5754495 2.96320009 0.29097917 0.33833333 0.38556667 0.04723333 8.210030e-01 1.867636e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105835 E001 0.9346885 0.154887518 1.000000000   7 106248298 106248307 10 - 0.244 0.227 -0.143
ENSG00000105835 E002 0.9346885 0.154887518 1.000000000   7 106248308 106248308 1 - 0.244 0.227 -0.143
ENSG00000105835 E003 0.9346885 0.154887518 1.000000000   7 106248309 106248312 4 - 0.244 0.227 -0.143
ENSG00000105835 E004 0.9346885 0.154887518 1.000000000   7 106248313 106248331 19 - 0.244 0.227 -0.143
ENSG00000105835 E005 1.4414731 0.277671846 0.790858112 0.89099956 7 106248332 106248367 36 - 0.311 0.381 0.424
ENSG00000105835 E006 13.2065106 0.427668705 0.187548822 0.41382581 7 106248368 106248709 342 - 0.981 1.279 1.071
ENSG00000105835 E007 108.7394389 1.435073752 0.693639520 0.83144600 7 106248710 106250038 1329 - 1.932 1.950 0.062
ENSG00000105835 E008 3.1398285 0.219917653 0.722196408 0.84942869 7 106250039 106250042 4 - 0.530 0.631 0.455
ENSG00000105835 E009 3.5865134 0.277335392 0.869150585 0.93549686 7 106250043 106250047 5 - 0.582 0.629 0.209
ENSG00000105835 E010 3.4368643 0.257499915 0.980095193 0.99185213 7 106250048 106250052 5 - 0.581 0.561 -0.091
ENSG00000105835 E011 43.6304399 0.897300989 0.640851890 0.79745146 7 106250053 106250430 378 - 1.539 1.578 0.134
ENSG00000105835 E012 35.8849448 0.779136344 0.370420916 0.60431230 7 106250431 106250551 121 - 1.415 1.627 0.726
ENSG00000105835 E013 29.0570449 0.678126459 0.243717871 0.48074082 7 106250552 106250671 120 - 1.300 1.602 1.041
ENSG00000105835 E014 8.9146132 0.224676526 0.024764218 0.11150530 7 106250672 106250700 29 - 0.767 1.246 1.778
ENSG00000105835 E015 9.2660868 0.274536904 0.042803054 0.16203311 7 106250701 106250744 44 - 0.789 1.253 1.716
ENSG00000105835 E016 61.7924727 0.931444126 0.337704010 0.57606533 7 106250745 106250835 91 - 1.634 1.885 0.849
ENSG00000105835 E017 216.0551918 1.619839846 0.468063163 0.67875134 7 106250836 106251193 358 - 2.177 2.406 0.763
ENSG00000105835 E018 4.6759579 0.007067722 0.953158371 0.97854643 7 106251194 106252513 1320 - 0.671 0.704 0.140
ENSG00000105835 E019 1.9932256 0.060406315 0.310939708 0.55136465 7 106252514 106253016 503 - 0.432 0.225 -1.329
ENSG00000105835 E020 201.2938546 0.003878060 0.052626546 0.18580839 7 106253017 106253151 135 - 2.181 2.287 0.353
ENSG00000105835 E021 2.4167374 0.009219878 0.220038706 0.45355864 7 106253152 106254116 965 - 0.404 0.642 1.138
ENSG00000105835 E022 1.5281195 0.111001550 0.359442287 0.59539389 7 106254117 106254363 247 - 0.285 0.485 1.152
ENSG00000105835 E023 231.4793480 0.002329964 0.783370331 0.88662965 7 106254364 106254504 141 - 2.252 2.297 0.150
ENSG00000105835 E024 3.2903782 0.249025180 0.199612487 0.42916925 7 106254505 106254836 332 - 0.463 0.772 1.370
ENSG00000105835 E025 19.2436034 0.016215640 0.349691730 0.58697908 7 106254837 106257483 2647 - 1.177 1.301 0.439
ENSG00000105835 E026 2.2547947 0.053363633 0.195934051 0.42446911 7 106258725 106258875 151 - 0.496 0.224 -1.660
ENSG00000105835 E027 7.3054677 0.010676747 0.013226429 0.07135851 7 106258876 106259287 412 - 0.889 0.481 -1.733
ENSG00000105835 E028 0.8383617 0.027481204 0.296988810   7 106259879 106259896 18 - 0.165 0.373 1.559
ENSG00000105835 E029 0.2852693 0.241217011 1.000000000   7 106259897 106259904 8 - 0.115 0.000 -11.804
ENSG00000105835 E030 0.8274031 0.017193929 1.000000000   7 106259905 106259927 23 - 0.208 0.225 0.141
ENSG00000105835 E031 1.0053869 0.015378759 0.899447607   7 106259928 106260029 102 - 0.248 0.225 -0.182
ENSG00000105835 E032 9.8606285 0.139397105 0.646608922 0.80124531 7 106260030 106261489 1460 - 0.953 0.856 -0.368
ENSG00000105835 E033 0.6600180 0.019010015 0.448019122   7 106261490 106261587 98 - 0.208 0.000 -13.127
ENSG00000105835 E034 136.6794868 0.016360626 0.570501055 0.75061555 7 106261588 106261707 120 - 2.031 2.043 0.039
ENSG00000105835 E035 0.3447487 0.900892946 0.109976403   7 106263150 106263391 242 - 0.000 0.379 13.304
ENSG00000105835 E036 255.9492977 0.010817331 0.540388688 0.72927078 7 106263392 106263606 215 - 2.303 2.306 0.010
ENSG00000105835 E037 98.3643934 0.017780931 0.579449987 0.75679617 7 106263607 106263617 11 - 1.878 1.946 0.230
ENSG00000105835 E038 3.4155578 0.007822572 0.049502730 0.17841791 7 106263618 106265009 1392 - 0.610 0.225 -2.183
ENSG00000105835 E039 1.2751332 0.023813624 0.606893326   7 106265010 106265171 162 - 0.318 0.224 -0.673
ENSG00000105835 E040 5.0016112 0.148976145 0.248864937 0.48664923 7 106265172 106266690 1519 - 0.627 0.891 1.066
ENSG00000105835 E041 1.5347090 0.501500862 0.602866234 0.77211817 7 106266691 106266769 79 - 0.280 0.505 1.276
ENSG00000105835 E042 1.1302857 0.022064412 0.727331858   7 106266770 106267826 1057 - 0.284 0.224 -0.451
ENSG00000105835 E043 0.2922838 0.025302230 0.301798656   7 106268335 106268463 129 - 0.062 0.224 2.136
ENSG00000105835 E044 198.6741077 0.018076757 0.721697863 0.84912196 7 106268464 106268600 137 - 2.194 2.196 0.007
ENSG00000105835 E045 193.8260979 0.014954521 0.405443095 0.63265917 7 106269154 106269312 159 - 2.188 2.165 -0.075
ENSG00000105835 E046 1.4418981 0.111980560 0.354959074 0.59170763 7 106269313 106269414 102 - 0.284 0.481 1.133
ENSG00000105835 E047 3.2780162 0.100717003 0.645672044 0.80059845 7 106269415 106269990 576 - 0.539 0.637 0.442
ENSG00000105835 E048 1.5054645 0.012198908 0.441318770 0.65965757 7 106269991 106270172 182 - 0.317 0.481 0.916
ENSG00000105835 E049 0.5775531 0.019387492 0.792947237   7 106270173 106270176 4 - 0.165 0.224 0.554
ENSG00000105835 E050 1.8117277 0.049163616 0.651356010 0.80440759 7 106270177 106270292 116 - 0.376 0.480 0.553
ENSG00000105835 E051 1.6620785 0.036437202 0.932769515 0.96851262 7 106270293 106270332 40 - 0.376 0.371 -0.026
ENSG00000105835 E052 3.5243184 0.007610399 0.413368931 0.63862480 7 106270333 106271094 762 - 0.610 0.481 -0.597
ENSG00000105835 E053 2.5925804 0.064540340 0.025224917 0.11288827 7 106271095 106272038 944 - 0.541 0.000 -14.974
ENSG00000105835 E054 0.4654660 0.023440429 0.671529085   7 106272039 106272106 68 - 0.165 0.000 -12.732
ENSG00000105835 E055 0.1426347 0.032410333 1.000000000   7 106272107 106272165 59 - 0.062 0.000 -11.184
ENSG00000105835 E056 0.4820342 0.021562097 0.666648849   7 106272166 106272460 295 - 0.165 0.000 -12.731
ENSG00000105835 E057 0.4820342 0.021562097 0.666648849   7 106272461 106272529 69 - 0.165 0.000 -12.731
ENSG00000105835 E058 215.0415679 0.009452144 0.005506449 0.03725436 7 106272530 106272655 126 - 2.249 2.134 -0.386
ENSG00000105835 E059 115.3499196 0.003840860 0.057088800 0.19624694 7 106272656 106272658 3 - 1.973 1.913 -0.202
ENSG00000105835 E060 0.0000000       7 106273034 106273139 106 -      
ENSG00000105835 E061 189.1546807 0.006878641 0.162349380 0.38026397 7 106274946 106275040 95 - 2.181 2.148 -0.110
ENSG00000105835 E062 70.1548844 0.006607840 0.255994304 0.49473354 7 106275041 106275043 3 - 1.756 1.714 -0.144
ENSG00000105835 E063 70.9315875 0.005251448 0.386273922 0.61751684 7 106275044 106275049 6 - 1.758 1.736 -0.073
ENSG00000105835 E064 0.1723744 0.096059982 0.103719236   7 106275050 106275068 19 - 0.000 0.225 13.372
ENSG00000105835 E065 0.9606717 0.263305119 1.000000000   7 106275069 106277022 1954 - 0.247 0.226 -0.170
ENSG00000105835 E066 122.4785001 0.004336178 0.040535351 0.15614350 7 106277023 106277083 61 - 1.999 1.929 -0.238
ENSG00000105835 E067 105.8816592 0.007062032 0.056195893 0.19408503 7 106277084 106277144 61 - 1.939 1.862 -0.259
ENSG00000105835 E068 87.7152947 0.009884534 0.185876457 0.41167085 7 106277145 106277179 35 - 1.854 1.801 -0.177
ENSG00000105835 E069 7.1299162 0.004728595 0.150220773 0.36265999 7 106284348 106284632 285 - 0.845 0.642 -0.822
ENSG00000105835 E070 0.3559677 0.704893020 1.000000000   7 106284664 106284827 164 - 0.120 0.000 -11.440
ENSG00000105835 E071 120.3825688 0.016098942 0.263492351 0.50274463 7 106284828 106284931 104 - 1.987 1.949 -0.128
ENSG00000105835 E072 48.6655946 0.034881271 0.969419987 0.98654568 7 106284932 106284981 50 - 1.584 1.649 0.220
ENSG00000105835 E073 26.3613532 0.030026143 0.260261788 0.49921994 7 106284982 106285192 211 - 1.305 1.484 0.620
ENSG00000105835 E074 0.0000000       7 106285318 106285436 119 -      
ENSG00000105835 E075 0.5963342 0.019687330 0.794164475   7 106285541 106285966 426 - 0.165 0.224 0.552