ENSG00000105784

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312373 ENSG00000105784 HEK293_OSMI2_6hA HEK293_TMG_6hB RUNDC3B protein_coding retained_intron 1.630717 0.5724524 2.807809 0.187975 0.1010249 2.274362 0.48749502 0.21502775 1.0772165 0.11967685 0.21790466 2.272464 0.35511667 0.4153000 0.37970000 -0.03560000 1.00000000 0.00239619 FALSE TRUE
ENST00000338056 ENSG00000105784 HEK293_OSMI2_6hA HEK293_TMG_6hB RUNDC3B protein_coding protein_coding 1.630717 0.5724524 2.807809 0.187975 0.1010249 2.274362 0.06186784 0.00000000 0.1469994 0.00000000 0.05635069 3.972687 0.03805417 0.0000000 0.05266667 0.05266667 0.50743722 0.00239619 FALSE TRUE
ENST00000394654 ENSG00000105784 HEK293_OSMI2_6hA HEK293_TMG_6hB RUNDC3B protein_coding protein_coding 1.630717 0.5724524 2.807809 0.187975 0.1010249 2.274362 0.90702638 0.08381413 1.5835929 0.02103627 0.09521133 4.086334 0.48983333 0.1571333 0.56763333 0.41050000 0.00239619 0.00239619 FALSE TRUE
ENST00000489461 ENSG00000105784 HEK293_OSMI2_6hA HEK293_TMG_6hB RUNDC3B protein_coding processed_transcript 1.630717 0.5724524 2.807809 0.187975 0.1010249 2.274362 0.08129376 0.12971356 0.0000000 0.12971356 0.00000000 -3.804400 0.03727500 0.1397667 0.00000000 -0.13976667 0.60148635 0.00239619 FALSE FALSE
ENST00000493037 ENSG00000105784 HEK293_OSMI2_6hA HEK293_TMG_6hB RUNDC3B protein_coding protein_coding 1.630717 0.5724524 2.807809 0.187975 0.1010249 2.274362 0.06241151 0.14389696 0.0000000 0.14389696 0.00000000 -3.943893 0.06900000 0.2878333 0.00000000 -0.28783333 0.72366269 0.00239619 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105784 E001 0.0000000       7 87627548 87627613 66 +      
ENSG00000105784 E002 0.0000000       7 87627672 87627856 185 +      
ENSG00000105784 E003 0.1426347 0.033084563 1.00000000   7 87628398 87628412 15 + 0.053 0.000 -8.070
ENSG00000105784 E004 0.3040503 0.027442404 1.00000000   7 87628413 87628449 37 + 0.101 0.000 -8.862
ENSG00000105784 E005 0.3040503 0.027442404 1.00000000   7 87628450 87628453 4 + 0.101 0.000 -8.862
ENSG00000105784 E006 9.1947863 0.313033580 0.60505328 0.77356574 7 87628454 87628945 492 + 0.872 0.913 0.155
ENSG00000105784 E007 0.0000000       7 87629230 87629308 79 +      
ENSG00000105784 E008 7.9880524 0.007962486 0.36402693 0.59907305 7 87650822 87650937 116 + 0.795 0.952 0.605
ENSG00000105784 E009 0.6600180 0.019787666 0.66606638   7 87693908 87693958 51 + 0.183 0.000 -9.842
ENSG00000105784 E010 0.0000000       7 87700416 87700420 5 +      
ENSG00000105784 E011 11.6111984 0.006581483 0.45800355 0.67175832 7 87700421 87700554 134 + 0.934 1.056 0.453
ENSG00000105784 E012 0.0000000       7 87700555 87700572 18 +      
ENSG00000105784 E013 0.0000000       7 87709250 87709507 258 +      
ENSG00000105784 E014 12.4470576 0.012173746 0.66581630 0.81354766 7 87710570 87710655 86 + 0.971 1.056 0.310
ENSG00000105784 E015 11.9293685 0.003671931 0.81658835 0.90619211 7 87739791 87739880 90 + 0.965 1.024 0.219
ENSG00000105784 E016 12.6291820 0.009984683 0.34653420 0.58413390 7 87741499 87741579 81 + 1.010 0.913 -0.364
ENSG00000105784 E017 16.5604372 0.002162429 0.67287504 0.81815203 7 87770581 87770749 169 + 1.101 1.085 -0.057
ENSG00000105784 E018 15.3477723 0.003236218 0.16912655 0.38942179 7 87777798 87777955 158 + 1.092 0.953 -0.509
ENSG00000105784 E019 10.9840469 0.003741316 0.04746065 0.17366378 7 87807373 87807519 147 + 0.971 0.698 -1.066
ENSG00000105784 E020 14.2768664 0.002467392 0.01282608 0.06974364 7 87816141 87816262 122 + 1.078 0.762 -1.197
ENSG00000105784 E021 86.3285582 0.022380786 0.09675708 0.27604498 7 87829885 87832296 2412 + 1.769 1.889 0.402