ENSG00000105778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318709 ENSG00000105778 HEK293_OSMI2_6hA HEK293_TMG_6hB AVL9 protein_coding protein_coding 7.898339 3.814605 13.02708 0.6668337 0.8003361 1.769238 4.9968746 2.5890256 8.400219 0.7865514 0.68597172 1.694173 0.62600417 0.66053333 0.6477667 -0.01276667 9.828248e-01 5.845202e-09 FALSE TRUE
MSTRG.29684.1 ENSG00000105778 HEK293_OSMI2_6hA HEK293_TMG_6hB AVL9 protein_coding   7.898339 3.814605 13.02708 0.6668337 0.8003361 1.769238 0.6078856 0.1487321 1.115267 0.1487321 0.25803683 2.825602 0.05993750 0.05930000 0.0838000 0.02450000 5.722095e-01 5.845202e-09 TRUE TRUE
MSTRG.29684.8 ENSG00000105778 HEK293_OSMI2_6hA HEK293_TMG_6hB AVL9 protein_coding   7.898339 3.814605 13.02708 0.6668337 0.8003361 1.769238 0.5091302 0.0000000 1.480201 0.0000000 0.09378005 7.219363 0.04235000 0.00000000 0.1138000 0.11380000 5.845202e-09 5.845202e-09 FALSE TRUE
MSTRG.29684.9 ENSG00000105778 HEK293_OSMI2_6hA HEK293_TMG_6hB AVL9 protein_coding   7.898339 3.814605 13.02708 0.6668337 0.8003361 1.769238 0.3063467 0.1973409 0.000000 0.0938721 0.00000000 -4.373933 0.06275833 0.05136667 0.0000000 -0.05136667 2.309996e-04 5.845202e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105778 E001 0.1426347 0.0322029372 1.0000000000   7 32495402 32495425 24 + 0.077 0.001 -7.082
ENSG00000105778 E002 0.3150090 0.0346257359 0.4680474934   7 32495426 32495448 23 + 0.077 0.187 1.480
ENSG00000105778 E003 1.1721518 0.0174569221 0.3778645267   7 32495449 32495488 40 + 0.249 0.418 1.066
ENSG00000105778 E004 5.8474358 0.0497908356 0.0217888574 0.101889810 7 32495489 32495520 32 + 0.634 1.016 1.504
ENSG00000105778 E005 5.9791117 0.0385953292 0.0483304851 0.175763911 7 32495521 32495525 5 + 0.671 0.990 1.252
ENSG00000105778 E006 6.1514861 0.0401197974 0.0314972636 0.131764005 7 32495526 32495527 2 + 0.671 1.014 1.341
ENSG00000105778 E007 8.2179674 0.0512895536 0.0122297722 0.067361722 7 32495528 32495535 8 + 0.753 1.156 1.512
ENSG00000105778 E008 14.7438652 0.0083959696 0.0011182290 0.010807022 7 32495536 32495584 49 + 1.020 1.355 1.194
ENSG00000105778 E009 18.9343752 0.0265453437 0.0059757556 0.039610490 7 32495585 32495631 47 + 1.125 1.456 1.160
ENSG00000105778 E010 40.6402205 0.0009648231 0.1144003687 0.306469878 7 32495632 32495802 171 + 1.532 1.644 0.381
ENSG00000105778 E011 0.7930990 0.1270024072 0.7436256453   7 32531615 32539269 7655 + 0.250 0.186 -0.545
ENSG00000105778 E012 51.0242833 0.0317915838 0.8844705135 0.943676311 7 32543141 32543254 114 + 1.659 1.685 0.086
ENSG00000105778 E013 30.1264579 0.0416172819 0.9013224711 0.952526454 7 32543255 32543261 7 + 1.445 1.442 -0.010
ENSG00000105778 E014 55.8415216 0.0178484275 0.5440772427 0.731993287 7 32544694 32544779 86 + 1.714 1.677 -0.127
ENSG00000105778 E015 56.6028036 0.0272680453 0.2811950704 0.521478934 7 32548847 32548918 72 + 1.732 1.639 -0.314
ENSG00000105778 E016 55.0063509 0.0318221884 0.1485872187 0.360276681 7 32551334 32551423 90 + 1.729 1.591 -0.470
ENSG00000105778 E017 44.6343103 0.0015396513 0.0144270149 0.075989050 7 32552229 32552295 67 + 1.639 1.501 -0.471
ENSG00000105778 E018 41.9441720 0.0017961222 0.1319111732 0.334821259 7 32553727 32553767 41 + 1.603 1.523 -0.273
ENSG00000105778 E019 41.0719542 0.0010266917 0.0246262794 0.111060884 7 32554558 32554596 39 + 1.605 1.478 -0.434
ENSG00000105778 E020 51.5737770 0.0009384719 0.1564524317 0.371535241 7 32558559 32558628 70 + 1.690 1.628 -0.211
ENSG00000105778 E021 90.3126066 0.0056668530 0.8365855704 0.917620240 7 32558929 32559222 294 + 1.905 1.929 0.080
ENSG00000105778 E022 87.1788904 0.0005479863 0.1675006532 0.387267482 7 32559223 32559464 242 + 1.905 1.864 -0.137
ENSG00000105778 E023 62.2656013 0.0054000140 0.2417727170 0.478515781 7 32570020 32570154 135 + 1.759 1.709 -0.172
ENSG00000105778 E024 4.3775171 0.0066530008 0.2545250102 0.493038597 7 32570155 32570166 12 + 0.736 0.567 -0.725
ENSG00000105778 E025 4.6009855 0.0056249679 0.1096764442 0.298501255 7 32573110 32573198 89 + 0.632 0.872 0.974
ENSG00000105778 E026 100.0805241 0.0028420018 0.4605708538 0.673580759 7 32573199 32573418 220 + 1.959 1.947 -0.040
ENSG00000105778 E027 69.0614663 0.0006728539 0.4697804136 0.679888865 7 32575955 32576072 118 + 1.800 1.783 -0.055
ENSG00000105778 E028 0.9772399 0.0185495642 0.5547124683   7 32580207 32580218 12 + 0.294 0.187 -0.845
ENSG00000105778 E029 48.0949530 0.0008531876 0.8452014590 0.922233949 7 32580219 32580272 54 + 1.631 1.660 0.098
ENSG00000105778 E030 2.6126448 0.0138520411 0.8570787248 0.928854381 7 32580763 32580790 28 + 0.521 0.499 -0.104
ENSG00000105778 E031 2.1064804 0.0099284132 0.3181175794 0.558044001 7 32580791 32580801 11 + 0.495 0.318 -0.981
ENSG00000105778 E032 57.1064014 0.0007971125 0.7454853214 0.863995639 7 32580802 32580890 89 + 1.716 1.717 0.003
ENSG00000105778 E033 113.0291370 0.0004091471 0.3059611878 0.546611473 7 32583792 32584102 311 + 2.012 1.993 -0.066
ENSG00000105778 E034 234.2973710 0.0004064383 0.0027860108 0.022100557 7 32584103 32585452 1350 + 2.334 2.274 -0.200
ENSG00000105778 E035 47.3974011 0.0011164713 0.3075846614 0.548243017 7 32585453 32585535 83 + 1.641 1.599 -0.141
ENSG00000105778 E036 109.8806625 0.0207451300 0.4568966140 0.670934151 7 32585536 32585925 390 + 2.001 1.976 -0.083
ENSG00000105778 E037 440.6442707 0.0050361030 0.0007083059 0.007511917 7 32585926 32588726 2801 + 2.553 2.686 0.445