ENSG00000105738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222345 ENSG00000105738 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L3 protein_coding protein_coding 8.027369 11.54554 5.106299 1.102673 0.5079785 -1.175412 4.6826024 7.7915434 2.8473518 0.9584611 0.1344424 -1.4490809 0.59306250 0.67360000 0.574533333 -0.09906667 0.80060792 0.01335599 FALSE TRUE
ENST00000594553 ENSG00000105738 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L3 protein_coding retained_intron 8.027369 11.54554 5.106299 1.102673 0.5079785 -1.175412 0.4712339 0.1020359 0.5991460 0.1020359 0.5991460 2.4428265 0.06764167 0.01063333 0.100333333 0.08970000 0.95366033 0.01335599 FALSE FALSE
ENST00000596403 ENSG00000105738 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L3 protein_coding retained_intron 8.027369 11.54554 5.106299 1.102673 0.5079785 -1.175412 1.0908872 0.9120600 0.0380524 0.1858123 0.0380524 -4.2621804 0.10658750 0.07753333 0.009033333 -0.06850000 0.01335599 0.01335599 FALSE TRUE
ENST00000601881 ENSG00000105738 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L3 protein_coding retained_intron 8.027369 11.54554 5.106299 1.102673 0.5079785 -1.175412 0.9439405 1.3323262 1.1022674 0.7378570 0.5084822 -0.2712316 0.13001667 0.11360000 0.214400000 0.10080000 0.84205564 0.01335599 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105738 E001 0.7390709 0.2377854305 4.097036e-01   19 37907143 37907207 65 + 0.000 0.235 9.797
ENSG00000105738 E002 5.0167744 0.0092421955 4.494363e-01 6.652807e-01 19 37907208 37907244 37 + 0.805 0.698 -0.430
ENSG00000105738 E003 16.9357955 0.0022823974 4.409154e-01 6.593992e-01 19 37907245 37907358 114 + 1.112 1.194 0.293
ENSG00000105738 E004 1.0422113 0.0155780786 5.095463e-02   19 37907544 37907974 431 + 0.530 0.182 -2.192
ENSG00000105738 E005 0.0000000       19 37932346 37932692 347 +      
ENSG00000105738 E006 16.7807306 0.0203571423 3.947291e-01 6.240895e-01 19 38029089 38029156 68 + 1.093 1.196 0.369
ENSG00000105738 E007 47.3745534 0.0032290237 1.285011e-02 6.982107e-02 19 38081256 38081505 250 + 1.719 1.567 -0.516
ENSG00000105738 E008 181.3436611 0.0044943216 5.005898e-02 1.798202e-01 19 38081506 38083099 1594 + 2.245 2.162 -0.277
ENSG00000105738 E009 0.0000000       19 38087756 38087787 32 +      
ENSG00000105738 E010 49.8649244 0.0008106169 3.931624e-01 6.229292e-01 19 38088721 38088851 131 + 1.666 1.621 -0.154
ENSG00000105738 E011 25.3879137 0.0029703294 5.951270e-01 7.671120e-01 19 38099962 38099981 20 + 1.316 1.366 0.174
ENSG00000105738 E012 58.8086825 0.0094836190 6.482719e-01 8.023650e-01 19 38099982 38100150 169 + 1.727 1.697 -0.100
ENSG00000105738 E013 63.8851463 0.0008855045 4.870184e-02 1.765884e-01 19 38101052 38101226 175 + 1.812 1.717 -0.321
ENSG00000105738 E014 0.3336024 0.0244411696 8.696902e-01   19 38106289 38106536 248 + 0.000 0.130 11.669
ENSG00000105738 E015 52.9086519 0.0008695896 1.736586e-03 1.527489e-02 19 38106537 38106640 104 + 1.779 1.615 -0.556
ENSG00000105738 E016 2.5284214 0.3455970811 6.218580e-01 7.850578e-01 19 38109664 38110076 413 + 0.531 0.475 -0.274
ENSG00000105738 E017 0.5171231 0.9491515577 1.000000e+00   19 38110199 38110226 28 + 0.000 0.188 10.765
ENSG00000105738 E018 60.8702082 0.0006495040 2.156057e-01 4.481540e-01 19 38110227 38110384 158 + 1.761 1.701 -0.203
ENSG00000105738 E019 94.6364169 0.0089853790 4.632263e-01 6.752946e-01 19 38119306 38119648 343 + 1.934 1.891 -0.143
ENSG00000105738 E020 87.2248184 0.0069439621 1.271851e-01 3.273682e-01 19 38119649 38119832 184 + 1.928 1.841 -0.291
ENSG00000105738 E021 58.5306908 0.0010432528 1.303608e-01 3.323764e-01 19 38119833 38119882 50 + 1.752 1.674 -0.265
ENSG00000105738 E022 103.4383334 0.0013576762 1.756945e-01 3.980500e-01 19 38130498 38130772 275 + 1.979 1.924 -0.185
ENSG00000105738 E023 0.1426347 0.0318810364 1.304976e-01   19 38130773 38130831 59 + 0.203 0.000 -13.474
ENSG00000105738 E024 0.1723744 0.0373929996 1.000000e+00   19 38131654 38131735 82 + 0.000 0.070 10.551
ENSG00000105738 E025 77.1772932 0.0032132814 7.360262e-02 2.319655e-01 19 38141184 38141435 252 + 1.882 1.795 -0.295
ENSG00000105738 E026 53.7533254 0.0008267297 6.279461e-02 2.090319e-01 19 38142573 38142710 138 + 1.738 1.642 -0.328
ENSG00000105738 E027 57.3712877 0.0025135150 5.123026e-01 7.096869e-01 19 38152840 38152967 128 + 1.719 1.687 -0.108
ENSG00000105738 E028 49.8306033 0.0121496310 1.867928e-01 4.127852e-01 19 38162253 38162371 119 + 1.544 1.657 0.386
ENSG00000105738 E029 80.4522763 0.0005113910 1.300039e-01 3.318551e-01 19 38164479 38164770 292 + 1.775 1.851 0.259
ENSG00000105738 E030 50.6321750 0.0038118749 1.801331e-02 8.907679e-02 19 38164771 38164906 136 + 1.498 1.662 0.561
ENSG00000105738 E031 0.0000000       19 38173626 38173672 47 +      
ENSG00000105738 E032 78.3220527 0.0009319938 4.573134e-01 6.712852e-01 19 38182519 38182740 222 + 1.787 1.827 0.132
ENSG00000105738 E033 0.1723744 0.0373929996 1.000000e+00   19 38182741 38182966 226 + 0.000 0.070 10.551
ENSG00000105738 E034 75.5718542 0.0006454769 1.985278e-01 4.277742e-01 19 38192145 38192310 166 + 1.850 1.793 -0.192
ENSG00000105738 E035 26.2850592 0.0201046183 3.904955e-01 6.208408e-01 19 38193537 38193539 3 + 1.427 1.345 -0.285
ENSG00000105738 E036 57.9252008 0.0008664976 7.626487e-02 2.372599e-01 19 38193540 38193780 241 + 1.613 1.719 0.359
ENSG00000105738 E037 48.9058898 0.0009229018 1.728239e-02 8.647459e-02 19 38198389 38198532 144 + 1.498 1.654 0.533
ENSG00000105738 E038 70.7406227 0.0009514292 1.565772e-01 3.716751e-01 19 38201862 38201997 136 + 1.714 1.791 0.262
ENSG00000105738 E039 1.5876690 0.2009845607 1.342960e-01 3.385872e-01 19 38203692 38204126 435 + 0.597 0.273 -1.755
ENSG00000105738 E040 59.8988137 0.0014332198 2.085168e-01 4.400790e-01 19 38204127 38204208 82 + 1.643 1.718 0.255
ENSG00000105738 E041 431.0317981 0.0017399183 4.579969e-07 1.433703e-05 19 38206097 38208369 2273 + 2.449 2.583 0.449