ENSG00000105698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222305 ENSG00000105698 HEK293_OSMI2_6hA HEK293_TMG_6hB USF2 protein_coding protein_coding 114.477 163.403 62.86708 34.99271 1.135231 -1.377917 20.43528 38.82836 8.053116 9.556304 1.0653633 -2.268073 0.1677000 0.2334667 0.1276667 -0.10580000 0.01816582 0.003095869 FALSE TRUE
ENST00000343550 ENSG00000105698 HEK293_OSMI2_6hA HEK293_TMG_6hB USF2 protein_coding protein_coding 114.477 163.403 62.86708 34.99271 1.135231 -1.377917 49.54437 65.58426 27.212249 15.124065 0.8640876 -1.268783 0.4275792 0.3973000 0.4334333 0.03613333 0.79636636 0.003095869 FALSE TRUE
ENST00000594064 ENSG00000105698 HEK293_OSMI2_6hA HEK293_TMG_6hB USF2 protein_coding protein_coding 114.477 163.403 62.86708 34.99271 1.135231 -1.377917 21.71786 32.25365 11.175348 6.951641 0.6964620 -1.528300 0.1894625 0.1976000 0.1778333 -0.01976667 0.79204566 0.003095869 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105698 E001 4.301818 0.0070550592 1.084509e-01 2.964646e-01 19 35268962 35268977 16 + 0.443 0.731 1.304
ENSG00000105698 E002 2.611991 0.0095102832 6.295860e-02 2.093650e-01 19 35268978 35269064 87 + 0.202 0.580 2.244
ENSG00000105698 E003 23.266712 0.0019302868 7.223684e-05 1.139747e-03 19 35269065 35269101 37 + 0.968 1.374 1.453
ENSG00000105698 E004 32.736093 0.0010910458 1.681338e-05 3.294449e-04 19 35269102 35269107 6 + 1.147 1.516 1.289
ENSG00000105698 E005 37.825502 0.0009498617 9.611453e-07 2.744193e-05 19 35269108 35269114 7 + 1.182 1.581 1.384
ENSG00000105698 E006 135.349709 0.0005354510 1.081429e-06 3.042099e-05 19 35269115 35269163 49 + 1.902 2.101 0.668
ENSG00000105698 E007 1.102123 0.0153787590 7.204531e-01   19 35269281 35269358 78 + 0.339 0.274 -0.429
ENSG00000105698 E008 240.249879 0.0005389618 9.918673e-04 9.849251e-03 19 35269446 35269492 47 + 2.230 2.331 0.338
ENSG00000105698 E009 13.988901 0.0024405340 2.339101e-01 4.696513e-01 19 35269493 35269580 88 + 0.995 1.130 0.492
ENSG00000105698 E010 280.238096 0.0007344793 4.418820e-02 1.655929e-01 19 35269581 35269600 20 + 2.329 2.389 0.198
ENSG00000105698 E011 542.005888 0.0011211329 1.484783e-03 1.350788e-02 19 35269601 35269699 99 + 2.597 2.676 0.262
ENSG00000105698 E012 3.465430 0.0072650277 6.790910e-01 8.221546e-01 19 35269700 35269802 103 + 0.527 0.601 0.338
ENSG00000105698 E013 496.442843 0.0009536388 2.714297e-07 9.032923e-06 19 35269803 35270003 201 + 2.521 2.649 0.426
ENSG00000105698 E014 11.974137 0.1528393986 2.201207e-01 4.536708e-01 19 35270004 35270262 259 + 1.218 0.969 -0.899
ENSG00000105698 E015 19.142824 0.0608542786 1.307954e-01 3.330295e-01 19 35270263 35270446 184 + 1.396 1.167 -0.804
ENSG00000105698 E016 348.134130 0.0002132669 3.032464e-04 3.762171e-03 19 35270447 35270449 3 + 2.400 2.490 0.298
ENSG00000105698 E017 538.392135 0.0001656484 2.998440e-04 3.727702e-03 19 35270450 35270493 44 + 2.602 2.673 0.237
ENSG00000105698 E018 859.358181 0.0001484135 8.870223e-02 2.613999e-01 19 35270494 35270597 104 + 2.878 2.855 -0.077
ENSG00000105698 E019 676.067832 0.0002893644 8.637049e-07 2.502166e-05 19 35270718 35270758 41 + 2.818 2.735 -0.275
ENSG00000105698 E020 812.291800 0.0006383099 6.919564e-05 1.098328e-03 19 35270759 35270805 47 + 2.889 2.816 -0.241
ENSG00000105698 E021 6.389293 0.0156866835 4.368736e-05 7.420602e-04 19 35271001 35271082 82 + 1.147 0.602 -2.117
ENSG00000105698 E022 957.338732 0.0001319120 2.079014e-07 7.134057e-06 19 35271083 35271141 59 + 2.958 2.890 -0.227
ENSG00000105698 E023 10.069725 0.1030272241 7.522755e-01 8.680812e-01 19 35275082 35275425 344 + 1.022 0.955 -0.249
ENSG00000105698 E024 7.624142 0.1795817826 5.671790e-01 7.481517e-01 19 35275783 35275900 118 + 0.965 0.835 -0.494
ENSG00000105698 E025 40.451902 0.1759656180 7.232986e-01 8.500909e-01 19 35276977 35278214 1238 + 1.567 1.533 -0.117
ENSG00000105698 E026 30.656235 0.1056252002 8.812942e-01 9.419997e-01 19 35278215 35278697 483 + 1.443 1.420 -0.078
ENSG00000105698 E027 1195.162196 0.0001250294 3.063642e-10 1.956813e-08 19 35278698 35278792 95 + 3.059 2.985 -0.247
ENSG00000105698 E028 10.922174 0.0301972513 9.135883e-01 9.589013e-01 19 35278793 35278945 153 + 0.996 1.001 0.018
ENSG00000105698 E029 754.525686 0.0001039631 9.444947e-03 5.571852e-02 19 35278946 35278969 24 + 2.832 2.796 -0.121
ENSG00000105698 E030 1024.967002 0.0006193690 4.445217e-01 6.617983e-01 19 35278970 35279074 105 + 2.944 2.933 -0.034
ENSG00000105698 E031 123.768779 0.0021616295 1.202992e-02 6.656966e-02 19 35279075 35279166 92 + 1.929 2.048 0.400
ENSG00000105698 E032 1425.916986 0.0007487388 6.368864e-02 2.110235e-01 19 35279167 35279558 392 + 3.053 3.085 0.106
ENSG00000105698 E033 590.584881 0.0013417793 6.597205e-02 2.160808e-01 19 35279559 35279664 106 + 2.658 2.707 0.162
ENSG00000105698 E034 370.410156 0.0002092096 4.012726e-03 2.923370e-02 19 35279665 35279821 157 + 2.442 2.512 0.232