ENSG00000105607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222214 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding protein_coding 44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 18.8310756 25.498280 10.059514 6.6366316 1.0939760 -1.340972 0.39231250 0.40733333 0.33073333 -0.07660000 8.473661e-01 9.254254e-09 FALSE TRUE
ENST00000585420 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding retained_intron 44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 2.1512671 3.497167 1.134732 0.6351973 0.7711894 -1.615297 0.05250417 0.06140000 0.03720000 -0.02420000 7.844962e-01 9.254254e-09 FALSE TRUE
ENST00000590627 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding retained_intron 44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 0.5431699 0.000000 2.233287 0.0000000 0.7254084 7.809470 0.01670833 0.00000000 0.07343333 0.07343333 9.254254e-09 9.254254e-09 FALSE TRUE
ENST00000591470 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding protein_coding 44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 2.3551394 2.963215 1.826472 0.3151026 0.3556555 -0.695087 0.05566667 0.04910000 0.05993333 0.01083333 8.665723e-01 9.254254e-09 FALSE TRUE
MSTRG.16527.1 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding   44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 7.2573948 12.785908 4.616534 2.9087862 0.7089849 -1.467679 0.15386667 0.20443333 0.15186667 -0.05256667 6.902854e-01 9.254254e-09 FALSE TRUE
MSTRG.16527.14 ENSG00000105607 HEK293_OSMI2_6hA HEK293_TMG_6hB GCDH protein_coding   44.0518 60.77209 30.41499 7.656672 0.1911323 -0.9983895 4.4126860 5.187588 2.995801 2.6565130 0.3988787 -0.790093 0.11243333 0.08203333 0.09843333 0.01640000 8.737898e-01 9.254254e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105607 E001 0.8265952 0.0170118685 0.5415786419   19 12891021 12891028 8 + 0.314 0.201 -0.850
ENSG00000105607 E002 1.1713439 0.0426050965 0.9547855531   19 12891029 12891077 49 + 0.314 0.298 -0.109
ENSG00000105607 E003 2.0580388 0.0383983154 0.8432932333 0.921282410 19 12891078 12891138 61 + 0.414 0.444 0.157
ENSG00000105607 E004 1.1955468 0.0160217876 0.9343806693   19 12891139 12891143 5 + 0.314 0.297 -0.114
ENSG00000105607 E005 2.0941280 0.0097723582 0.3228110745 0.562158080 19 12891144 12891159 16 + 0.314 0.499 1.021
ENSG00000105607 E006 1.9632599 0.0109036352 0.4003064817 0.628519038 19 12891160 12891160 1 + 0.314 0.471 0.884
ENSG00000105607 E007 2.2721118 0.0225411543 0.6439399694 0.799471898 19 12891161 12891163 3 + 0.414 0.499 0.431
ENSG00000105607 E008 2.2968622 0.0092912410 0.2572222135 0.495980074 19 12891164 12891165 2 + 0.314 0.525 1.148
ENSG00000105607 E009 2.2968622 0.0092912410 0.2572222135 0.495980074 19 12891166 12891166 1 + 0.314 0.525 1.148
ENSG00000105607 E010 3.0759819 0.0421177993 0.9679457793 0.985819316 19 12891167 12891167 1 + 0.565 0.571 0.031
ENSG00000105607 E011 17.1643301 0.0032085512 0.4627414890 0.674980353 19 12891168 12891176 9 + 1.255 1.185 -0.248
ENSG00000105607 E012 20.8613622 0.0020056619 0.0349748421 0.141515156 19 12891177 12891179 3 + 1.405 1.232 -0.603
ENSG00000105607 E013 115.1320696 0.0017789240 0.9302357522 0.967101375 19 12891180 12891202 23 + 2.017 2.010 -0.025
ENSG00000105607 E014 14.1258714 0.0027567331 0.3416130111 0.579435250 19 12891203 12891268 66 + 1.201 1.106 -0.339
ENSG00000105607 E015 13.0956143 0.0048912606 0.3473418650 0.584842421 19 12891269 12891270 2 + 1.171 1.071 -0.359
ENSG00000105607 E016 242.6794604 0.0005420316 0.1964348689 0.425087399 19 12891271 12891395 125 + 2.313 2.345 0.107
ENSG00000105607 E017 197.2960576 0.0002738093 0.8977355415 0.950676221 19 12891487 12891522 36 + 2.247 2.247 0.000
ENSG00000105607 E018 28.4174378 0.0869740470 0.0251472844 0.112665540 19 12891523 12891660 138 + 1.643 1.296 -1.192
ENSG00000105607 E019 32.5234716 0.0355606626 0.0114381987 0.064169311 19 12891661 12891830 170 + 1.664 1.378 -0.980
ENSG00000105607 E020 362.0548828 0.0002180586 0.2538643042 0.492258481 19 12891831 12891974 144 + 2.528 2.500 -0.093
ENSG00000105607 E021 284.6310335 0.0001914803 0.4084681393 0.634861105 19 12892116 12892178 63 + 2.422 2.399 -0.076
ENSG00000105607 E022 6.8119745 0.0434641971 0.4984764901 0.699754271 19 12892179 12892283 105 + 0.926 0.813 -0.436
ENSG00000105607 E023 4.6078572 0.0099116524 0.0377921208 0.149062736 19 12892317 12892386 70 + 0.898 0.596 -1.229
ENSG00000105607 E024 5.5630351 0.0668475972 0.2976734035 0.538183574 19 12892387 12892434 48 + 0.897 0.712 -0.732
ENSG00000105607 E025 403.1411728 0.0001559619 0.9699995399 0.986840242 19 12893483 12893653 171 + 2.559 2.555 -0.014
ENSG00000105607 E026 14.6583191 0.1855205632 0.0481893723 0.175446684 19 12893654 12893882 229 + 1.406 0.985 -1.498
ENSG00000105607 E027 394.4926790 0.0001559329 0.9637303749 0.983763453 19 12895992 12896121 130 + 2.549 2.546 -0.008
ENSG00000105607 E028 261.0134688 0.0002597798 0.1203264163 0.316360157 19 12896205 12896239 35 + 2.398 2.356 -0.137
ENSG00000105607 E029 433.5056358 0.0007376339 0.7623095804 0.873981933 19 12896240 12896421 182 + 2.586 2.589 0.011
ENSG00000105607 E030 314.7573109 0.0007200030 0.0932578101 0.269796444 19 12896910 12897013 104 + 2.422 2.460 0.129
ENSG00000105607 E031 284.4462381 0.0002713841 0.1848078950 0.410251254 19 12897303 12897379 77 + 2.384 2.413 0.095
ENSG00000105607 E032 209.8487299 0.0002321084 0.0875535687 0.259174985 19 12897380 12897428 49 + 2.242 2.286 0.148
ENSG00000105607 E033 20.2188699 0.1018003188 0.0777741068 0.240334670 19 12897429 12897702 274 + 1.469 1.174 -1.029
ENSG00000105607 E034 423.6494138 0.0002131095 0.0247998799 0.111600774 19 12897703 12897863 161 + 2.548 2.589 0.135
ENSG00000105607 E035 14.0751858 0.1900950328 0.2722657069 0.512162201 19 12898126 12898383 258 + 1.256 1.070 -0.665
ENSG00000105607 E036 315.6211060 0.0002336791 0.2926900400 0.533423844 19 12899468 12899570 103 + 2.434 2.454 0.068
ENSG00000105607 E037 228.4456764 0.0033093118 0.2880142997 0.528768155 19 12899571 12899699 129 + 2.281 2.315 0.113
ENSG00000105607 E038 141.7740422 0.0098042818 0.9233242491 0.963954716 19 12899700 12900139 440 + 2.110 2.097 -0.041
ENSG00000105607 E039 24.9914502 0.4099959820 0.6279691185 0.789215988 19 12900234 12900318 85 + 1.349 1.370 0.074
ENSG00000105607 E040 33.4382928 0.4800308472 0.4318905790 0.652657114 19 12900319 12900670 352 + 1.375 1.519 0.495
ENSG00000105607 E041 4.5800659 0.2281811223 0.7033254712 0.837728483 19 12902399 12902533 135 + 0.759 0.673 -0.354
ENSG00000105607 E042 5.3460004 0.0818334451 0.2075290447 0.438851236 19 12905954 12906023 70 + 0.900 0.667 -0.929
ENSG00000105607 E043 17.7904056 0.0019787572 0.0001544557 0.002151951 19 12913995 12914469 475 + 1.431 1.113 -1.120