ENSG00000105556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264819 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding protein_coding 21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 11.4386793 18.040909 5.1622600 4.0342434 0.62482912 -1.8032048 0.50952917 0.58490000 0.365400000 -0.219500000 0.02003066 0.02003066 FALSE TRUE
ENST00000586994 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding retained_intron 21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 1.3810698 1.342190 1.9654188 0.4430832 0.17798953 0.5468602 0.07812917 0.05420000 0.141633333 0.087433333 0.25701058 0.02003066 FALSE TRUE
ENST00000635755 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding nonsense_mediated_decay 21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 2.9577965 3.358780 1.6317590 1.2943406 0.88014721 -1.0369839 0.13995833 0.10300000 0.107933333 0.004933333 1.00000000 0.02003066 FALSE FALSE
MSTRG.15974.3 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding   21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 1.0085811 2.051225 0.1200979 1.1545345 0.12009789 -3.9858324 0.04666667 0.07286667 0.009866667 -0.063000000 0.66080797 0.02003066 FALSE TRUE
MSTRG.15974.4 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding   21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 2.4070830 2.741011 3.3617400 0.5617525 0.69226554 0.2935312 0.13025833 0.09030000 0.241200000 0.150900000 0.04396304 0.02003066 FALSE TRUE
MSTRG.15974.5 ENSG00000105556 HEK293_OSMI2_6hA HEK293_TMG_6hB MIER2 protein_coding   21.04345 30.15034 14.10325 5.23667 1.364879 -1.095602 0.9623562 1.360443 1.2542651 0.3300842 0.05832535 -0.1163431 0.05372083 0.05140000 0.091000000 0.039600000 0.59020986 0.02003066 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105556 E001 158.1615378 0.0490865605 0.029840595 0.12685857 19 305573 306213 641 - 1.958 2.193 0.790
ENSG00000105556 E002 100.7375576 0.1725737456 0.008129349 0.04991686 19 306214 306476 263 - 1.519 2.034 1.744
ENSG00000105556 E003 153.1680689 0.0051336469 0.001132920 0.01091422 19 306477 306684 208 - 1.993 2.175 0.607
ENSG00000105556 E004 72.0657822 0.0019739017 0.165587556 0.38468113 19 306685 306711 27 - 1.739 1.838 0.335
ENSG00000105556 E005 265.1052879 0.0025430978 0.107607068 0.29503456 19 307119 307536 418 - 2.310 2.390 0.270
ENSG00000105556 E006 114.2258895 0.0086736782 0.999217252 1.00000000 19 308577 308665 89 - 1.982 2.012 0.101
ENSG00000105556 E007 69.8086827 0.0042412615 0.553242787 0.73853874 19 308801 308821 21 - 1.800 1.796 -0.013
ENSG00000105556 E008 129.5840657 0.0004129047 0.265962841 0.50540568 19 308822 308925 104 - 2.072 2.059 -0.041
ENSG00000105556 E009 138.7992622 0.0005002042 0.648458818 0.80250701 19 311845 311939 95 - 2.082 2.092 0.034
ENSG00000105556 E010 135.1122579 0.0018522828 0.906330996 0.95525740 19 312191 312272 82 - 2.062 2.080 0.063
ENSG00000105556 E011 211.3188926 0.0011418106 0.740653917 0.86082928 19 313492 313643 152 - 2.258 2.274 0.053
ENSG00000105556 E012 159.8860939 0.0023939669 0.161872683 0.37954003 19 325635 325704 70 - 2.168 2.140 -0.094
ENSG00000105556 E013 161.5252937 0.0011039580 0.104412018 0.28959418 19 326507 326593 87 - 2.175 2.147 -0.094
ENSG00000105556 E014 90.4261547 0.0005058513 0.033028391 0.13613039 19 326594 326598 5 - 1.950 1.888 -0.207
ENSG00000105556 E015 23.5251245 0.0790364475 0.004769014 0.03337406 19 326620 327063 444 - 1.595 1.188 -1.411
ENSG00000105556 E016 10.1238444 0.1221588417 0.055067873 0.19148204 19 327064 327132 69 - 1.211 0.875 -1.231
ENSG00000105556 E017 175.0305396 0.0002708052 0.091922206 0.26726655 19 327133 327256 124 - 2.209 2.186 -0.077
ENSG00000105556 E018 160.7647510 0.0003082123 0.012793812 0.06959408 19 327864 327989 126 - 2.193 2.143 -0.167
ENSG00000105556 E019 5.4563544 0.0168858126 0.808114305 0.90108663 19 330264 330380 117 - 0.770 0.749 -0.084
ENSG00000105556 E020 0.8507255 0.1219404927 0.203325776   19 334115 334399 285 - 0.000 0.293 9.910
ENSG00000105556 E021 141.4487663 0.0015110187 0.040977508 0.15726025 19 334400 334542 143 - 2.135 2.082 -0.176
ENSG00000105556 E022 71.5939870 0.0111936323 0.423633291 0.64635039 19 336083 336173 91 - 1.832 1.792 -0.134
ENSG00000105556 E023 1.6954367 0.0119738048 0.850313774 0.92519214 19 336174 336194 21 - 0.420 0.403 -0.094
ENSG00000105556 E024 6.0828532 0.0673055707 0.856772809 0.92871377 19 340514 340607 94 - 0.812 0.791 -0.082
ENSG00000105556 E025 4.9097649 0.0064016370 0.002040459 0.01733191 19 343285 343360 76 - 0.986 0.588 -1.599
ENSG00000105556 E026 7.9599234 0.1169572336 0.264371077 0.50358133 19 343677 343809 133 - 1.031 0.844 -0.702
ENSG00000105556 E027 10.9021357 0.1099300702 0.407283268 0.63393162 19 343810 343938 129 - 1.114 0.987 -0.464
ENSG00000105556 E028 37.0323188 0.0010834605 0.009165487 0.05455315 19 344774 344815 42 - 1.621 1.484 -0.469