ENSG00000105429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251268 ENSG00000105429 HEK293_OSMI2_6hA HEK293_TMG_6hB MEGF8 protein_coding protein_coding 36.69574 60.04958 23.03142 6.024464 0.2923408 -1.382165 1.902497 2.150123 2.073168 0.3335197 0.33786782 -0.05233472 0.05978750 0.03683333 0.08973333 0.05290000 0.119831261 0.007027846 FALSE TRUE
ENST00000593647 ENSG00000105429 HEK293_OSMI2_6hA HEK293_TMG_6hB MEGF8 protein_coding protein_coding 36.69574 60.04958 23.03142 6.024464 0.2923408 -1.382165 16.125844 25.114999 7.048860 3.0535465 0.07707439 -1.83161643 0.40084583 0.41646667 0.30613333 -0.11033333 0.007027846 0.007027846 FALSE TRUE
MSTRG.17232.3 ENSG00000105429 HEK293_OSMI2_6hA HEK293_TMG_6hB MEGF8 protein_coding   36.69574 60.04958 23.03142 6.024464 0.2923408 -1.382165 6.348264 12.386286 3.011214 0.4752016 0.19866085 -2.03670773 0.18120000 0.20886667 0.13076667 -0.07810000 0.071655653 0.007027846 FALSE TRUE
MSTRG.17232.4 ENSG00000105429 HEK293_OSMI2_6hA HEK293_TMG_6hB MEGF8 protein_coding   36.69574 60.04958 23.03142 6.024464 0.2923408 -1.382165 7.798874 15.918320 6.701958 2.2974205 0.49574961 -1.24678846 0.23202500 0.26296667 0.29140000 0.02843333 0.857271092 0.007027846 FALSE TRUE
MSTRG.17232.9 ENSG00000105429 HEK293_OSMI2_6hA HEK293_TMG_6hB MEGF8 protein_coding   36.69574 60.04958 23.03142 6.024464 0.2923408 -1.382165 2.002938 1.668712 2.709409 0.5969638 0.61045041 0.69593864 0.05369167 0.02843333 0.11730000 0.08886667 0.053864067 0.007027846 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105429 E001 3.195699 0.0078734206 6.030799e-01 7.722900e-01 19 42325609 42325631 23 + 0.626 0.547 -0.357
ENSG00000105429 E002 3.844498 0.0106004033 3.779870e-01 6.105281e-01 19 42325632 42325634 3 + 0.725 0.592 -0.564
ENSG00000105429 E003 8.408000 0.0042012876 4.179628e-01 6.420946e-01 19 42325635 42325651 17 + 0.982 0.891 -0.343
ENSG00000105429 E004 9.201459 0.0039296659 3.320639e-01 5.709261e-01 19 42325652 42325654 3 + 1.028 0.922 -0.394
ENSG00000105429 E005 75.080912 0.0021767139 3.513451e-01 5.885006e-01 19 42325655 42325725 71 + 1.787 1.843 0.190
ENSG00000105429 E006 245.648393 0.0002320944 3.144919e-02 1.316341e-01 19 42325726 42326091 366 + 2.371 2.324 -0.156
ENSG00000105429 E007 239.601444 0.0024255570 1.492205e-03 1.356371e-02 19 42326092 42326430 339 + 2.398 2.294 -0.346
ENSG00000105429 E008 166.374816 0.0016186508 2.080161e-05 3.951002e-04 19 42333605 42333768 164 + 2.270 2.129 -0.472
ENSG00000105429 E009 202.892259 0.0024295171 8.317682e-03 5.078499e-02 19 42334007 42334213 207 + 2.319 2.232 -0.289
ENSG00000105429 E010 198.600728 0.0003048487 2.319194e-01 4.674142e-01 19 42335035 42335215 181 + 2.267 2.242 -0.085
ENSG00000105429 E011 153.496628 0.0003178088 1.126702e-03 1.086727e-02 19 42335297 42335385 89 + 2.205 2.111 -0.314
ENSG00000105429 E012 256.892110 0.0005320139 8.988659e-02 2.635532e-01 19 42335931 42336211 281 + 2.386 2.350 -0.121
ENSG00000105429 E013 197.496482 0.0014193069 1.214981e-01 3.182528e-01 19 42336212 42336346 135 + 2.276 2.234 -0.141
ENSG00000105429 E014 198.918032 0.0003221424 4.612279e-04 5.322942e-03 19 42336807 42336952 146 + 2.311 2.221 -0.301
ENSG00000105429 E015 177.562333 0.0052497973 1.080467e-02 6.154545e-02 19 42337084 42337206 123 + 2.274 2.162 -0.377
ENSG00000105429 E016 166.372182 0.0030129966 1.684351e-01 3.884745e-01 19 42343477 42343631 155 + 2.202 2.152 -0.169
ENSG00000105429 E017 147.307568 0.0031841341 9.025774e-01 9.531291e-01 19 42343954 42344073 120 + 2.113 2.113 0.000
ENSG00000105429 E018 157.152862 0.0002671936 4.705306e-01 6.804410e-01 19 42344441 42344585 145 + 2.157 2.143 -0.047
ENSG00000105429 E019 207.820790 0.0032139542 5.907020e-03 3.928521e-02 19 42344670 42344833 164 + 2.335 2.237 -0.326
ENSG00000105429 E020 263.009163 0.0053515648 2.807249e-03 2.223165e-02 19 42348272 42348472 201 + 2.452 2.330 -0.409
ENSG00000105429 E021 179.962854 0.0002509249 1.589878e-08 7.127715e-07 19 42349499 42349699 201 + 2.311 2.158 -0.513
ENSG00000105429 E022 249.522137 0.0008632551 9.577076e-03 5.630436e-02 19 42350148 42350384 237 + 2.391 2.326 -0.219
ENSG00000105429 E023 197.502743 0.0002898996 1.656204e-01 3.846819e-01 19 42351216 42351334 119 + 2.266 2.234 -0.105
ENSG00000105429 E024 218.669485 0.0014070817 1.279828e-01 3.286172e-01 19 42351429 42351560 132 + 2.317 2.274 -0.142
ENSG00000105429 E025 204.632114 0.0002403299 5.142141e-02 1.831143e-01 19 42351648 42351761 114 + 2.294 2.248 -0.152
ENSG00000105429 E026 251.586145 0.0003430098 9.594563e-02 2.746620e-01 19 42352208 42352456 249 + 2.373 2.338 -0.117
ENSG00000105429 E027 2.289415 0.0103653904 6.901281e-01 8.291625e-01 19 42352796 42352927 132 + 0.417 0.495 0.400
ENSG00000105429 E028 174.871847 0.0011857600 7.168493e-02 2.281879e-01 19 42352928 42353127 200 + 2.137 2.207 0.235
ENSG00000105429 E029 201.377893 0.0002395539 8.639723e-02 2.572181e-01 19 42353465 42353675 211 + 2.209 2.268 0.197
ENSG00000105429 E030 280.603568 0.0002535740 9.466343e-01 9.756210e-01 19 42353775 42354024 250 + 2.392 2.399 0.024
ENSG00000105429 E031 203.860136 0.0002114599 6.237025e-01 7.863999e-01 19 42354588 42354720 133 + 2.262 2.257 -0.016
ENSG00000105429 E032 257.769781 0.0002032231 1.201690e-01 3.161155e-01 19 42355758 42356005 248 + 2.323 2.371 0.163
ENSG00000105429 E033 209.439410 0.0002224587 7.231451e-01 8.500438e-01 19 42356083 42356193 111 + 2.271 2.270 -0.003
ENSG00000105429 E034 229.916401 0.0003710354 9.505870e-01 9.772549e-01 19 42356335 42356453 119 + 2.307 2.314 0.024
ENSG00000105429 E035 264.939490 0.0002090528 2.663567e-01 5.058713e-01 19 42356774 42356981 208 + 2.344 2.381 0.124
ENSG00000105429 E036 264.617062 0.0002419837 3.957499e-01 6.250275e-01 19 42357404 42357584 181 + 2.347 2.378 0.101
ENSG00000105429 E037 272.761900 0.0002252426 8.234324e-01 9.099104e-01 19 42358144 42358307 164 + 2.374 2.388 0.048
ENSG00000105429 E038 21.390301 0.0015943277 2.044098e-04 2.723695e-03 19 42358787 42358954 168 + 1.485 1.207 -0.970
ENSG00000105429 E039 267.002853 0.0005117882 5.158878e-01 7.121784e-01 19 42359098 42359242 145 + 2.356 2.381 0.085
ENSG00000105429 E040 288.541093 0.0006506153 1.050755e-02 6.028864e-02 19 42360775 42360969 195 + 2.350 2.428 0.258
ENSG00000105429 E041 157.478677 0.0003034215 8.675965e-02 2.577979e-01 19 42360970 42361006 37 + 2.096 2.161 0.219
ENSG00000105429 E042 231.587696 0.0002408152 6.412177e-01 7.976495e-01 19 42362090 42362213 124 + 2.296 2.317 0.071
ENSG00000105429 E043 308.716924 0.0001869005 1.484417e-01 3.600366e-01 19 42362384 42362597 214 + 2.455 2.430 -0.082
ENSG00000105429 E044 286.168924 0.0007848621 8.042201e-01 8.987567e-01 19 42363048 42363262 215 + 2.404 2.405 0.003
ENSG00000105429 E045 269.156334 0.0001918147 2.980010e-01 5.384495e-01 19 42368455 42368662 208 + 2.353 2.388 0.117
ENSG00000105429 E046 263.829147 0.0002034514 9.082688e-02 2.652537e-01 19 42368843 42369002 160 + 2.330 2.382 0.174
ENSG00000105429 E047 185.906689 0.0002824464 5.092949e-02 1.818812e-01 19 42369531 42369630 100 + 2.166 2.235 0.230
ENSG00000105429 E048 216.714457 0.0007321781 2.634350e-02 1.163217e-01 19 42369631 42369723 93 + 2.226 2.303 0.256
ENSG00000105429 E049 335.151123 0.0009142192 3.061446e-01 5.468069e-01 19 42370189 42370359 171 + 2.485 2.467 -0.061
ENSG00000105429 E050 1.143442 0.0740951127 4.789148e-01   19 42370628 42370700 73 + 0.187 0.335 1.113
ENSG00000105429 E051 326.495539 0.0008046697 8.425336e-01 9.208963e-01 19 42370701 42370831 131 + 2.459 2.462 0.010
ENSG00000105429 E052 183.572773 0.0005901570 5.620444e-01 7.447033e-01 19 42371350 42371482 133 + 2.219 2.209 -0.033
ENSG00000105429 E053 326.857918 0.0003913570 8.437158e-01 9.214536e-01 19 42375507 42376250 744 + 2.460 2.464 0.012
ENSG00000105429 E054 3370.130715 0.0005870747 1.640503e-11 1.361658e-09 19 42376251 42378699 2449 + 3.410 3.492 0.272
ENSG00000105429 E055 156.146132 0.0004216421 2.724284e-02 1.190178e-01 19 42378700 42378769 70 + 2.080 2.164 0.280