ENSG00000105426

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262963 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding protein_coding 29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 6.671820 9.372431 1.666652 1.0799831 0.8361726 -2.4843781 0.20983750 0.23320000 0.08926667 -0.14393333 6.759352e-01 2.923713e-05 FALSE TRUE
ENST00000591760 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding protein_coding 29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 5.252592 7.018094 1.868061 3.5426844 0.2361539 -1.9038893 0.16467083 0.16296667 0.09686667 -0.06610000 1.000000e+00 2.923713e-05   FALSE
ENST00000592099 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding protein_coding 29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 3.943655 4.424084 6.708539 0.4112914 0.4830374 0.5995116 0.16117083 0.11390000 0.34883333 0.23493333 2.923713e-05 2.923713e-05 FALSE TRUE
MSTRG.16239.17 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding   29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 1.629414 1.767217 1.115494 0.5855456 0.5768156 -0.6590612 0.05659167 0.04256667 0.05653333 0.01396667 9.949975e-01 2.923713e-05 FALSE TRUE
MSTRG.16239.4 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding   29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 3.515548 6.547978 1.957558 0.9707066 0.2502239 -1.7368453 0.11973333 0.16816667 0.10276667 -0.06540000 5.653920e-01 2.923713e-05 FALSE TRUE
MSTRG.16239.5 ENSG00000105426 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRS protein_coding   29.14205 39.98525 19.18887 3.333708 0.5482263 -1.058807 4.907228 7.402559 3.851489 0.6048285 0.3654099 -0.9408143 0.17139167 0.18990000 0.20080000 0.01090000 9.647535e-01 2.923713e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105426 E001 0.4756169 0.0224413943 4.067895e-01   19 5158495 5159104 610 - 0.000 0.209 11.725
ENSG00000105426 E002 0.0000000       19 5173969 5174082 114 -      
ENSG00000105426 E003 134.2132883 0.8782823775 2.373848e-01 4.735287e-01 19 5205508 5205647 140 - 1.741 2.173 1.452
ENSG00000105426 E004 126.0069738 0.6270327082 1.682266e-01 3.881950e-01 19 5205648 5205668 21 - 1.710 2.146 1.468
ENSG00000105426 E005 102.9370058 0.5607483944 1.526101e-01 3.660527e-01 19 5205669 5205671 3 - 1.620 2.060 1.485
ENSG00000105426 E006 350.2172118 1.2326976257 2.819434e-01 5.222860e-01 19 5205672 5205945 274 - 2.134 2.590 1.521
ENSG00000105426 E007 180.0811358 0.9782099007 2.436555e-01 4.806680e-01 19 5205946 5206069 124 - 1.854 2.302 1.500
ENSG00000105426 E008 105.2255520 0.6440429338 2.706909e-01 5.106081e-01 19 5206070 5206120 51 - 1.734 2.052 1.070
ENSG00000105426 E009 188.5096232 1.0800772456 3.479885e-01 5.854321e-01 19 5206121 5206367 247 - 1.964 2.307 1.148
ENSG00000105426 E010 70.0623344 0.4708120219 1.975813e-01 4.265800e-01 19 5206368 5206432 65 - 1.530 1.883 1.196
ENSG00000105426 E011 61.2889623 0.5019536179 3.194799e-01 5.592323e-01 19 5206433 5206516 84 - 1.560 1.808 0.842
ENSG00000105426 E012 52.9940551 0.4244301247 2.526687e-01 4.908031e-01 19 5206517 5206536 20 - 1.467 1.753 0.977
ENSG00000105426 E013 69.0668081 0.4219811759 1.334908e-01 3.372681e-01 19 5206537 5206577 41 - 1.474 1.885 1.396
ENSG00000105426 E014 200.4091519 1.0941381624 3.395034e-01 5.775446e-01 19 5206578 5206842 265 - 1.982 2.335 1.180
ENSG00000105426 E015 178.1362661 0.0158030996 2.129038e-03 1.793628e-02 19 5207922 5208042 121 - 2.003 2.271 0.897
ENSG00000105426 E016 99.3800339 0.0004014298 1.090851e-06 3.063529e-05 19 5208043 5208057 15 - 1.745 2.024 0.940
ENSG00000105426 E017 249.8156590 0.0002138589 9.973378e-05 1.491204e-03 19 5208237 5208391 155 - 2.230 2.399 0.564
ENSG00000105426 E018 234.8569968 0.0026039619 2.610166e-01 5.000408e-01 19 5210469 5210594 126 - 2.249 2.358 0.362
ENSG00000105426 E019 282.2451075 0.0023550236 6.429122e-01 7.987569e-01 19 5210679 5210805 127 - 2.371 2.422 0.173
ENSG00000105426 E020 331.9758591 0.0013831003 1.001764e-01 2.821085e-01 19 5211590 5211768 179 - 2.463 2.484 0.070
ENSG00000105426 E021 356.0805113 0.0024392201 2.686646e-01 5.083274e-01 19 5211965 5212250 286 - 2.487 2.517 0.101
ENSG00000105426 E022 243.7997886 0.0019113779 5.631357e-02 1.943610e-01 19 5212337 5212491 155 - 2.344 2.347 0.009
ENSG00000105426 E023 204.1328591 0.0002725864 1.166720e-02 6.510346e-02 19 5214361 5214480 120 - 2.273 2.267 -0.020
ENSG00000105426 E024 281.3553083 0.0023255366 6.651086e-03 4.294868e-02 19 5214561 5214736 176 - 2.421 2.399 -0.074
ENSG00000105426 E025 199.7873990 0.0024075235 3.996813e-03 2.913594e-02 19 5215289 5215366 78 - 2.284 2.247 -0.122
ENSG00000105426 E026 165.1032271 0.0019021178 2.493497e-03 2.029004e-02 19 5215367 5215412 46 - 2.207 2.164 -0.145
ENSG00000105426 E027 207.6240270 0.0024577063 2.617329e-04 3.341129e-03 19 5215498 5215595 98 - 2.318 2.256 -0.207
ENSG00000105426 E028 9.0801970 0.0034980106 8.093761e-01 9.018162e-01 19 5216720 5216767 48 - 0.907 0.993 0.324
ENSG00000105426 E029 187.3922864 0.0009083862 1.715467e-03 1.512673e-02 19 5218420 5218532 113 - 2.255 2.222 -0.109
ENSG00000105426 E030 14.8647234 0.2320785960 3.671497e-01 6.016643e-01 19 5218533 5218786 254 - 1.187 1.142 -0.158
ENSG00000105426 E031 41.2131437 0.0014703686 7.026913e-02 2.253057e-01 19 5218787 5218798 12 - 1.617 1.571 -0.157
ENSG00000105426 E032 29.3448549 0.1099436971 8.668259e-02 2.576674e-01 19 5218799 5219309 511 - 1.543 1.388 -0.533
ENSG00000105426 E033 193.2579908 0.0022195425 7.269454e-02 2.301621e-01 19 5219310 5219467 158 - 2.243 2.245 0.006
ENSG00000105426 E034 199.1286851 0.0048008226 9.130232e-02 2.660701e-01 19 5219939 5220154 216 - 2.263 2.255 -0.027
ENSG00000105426 E035 152.2474051 0.0007828764 3.439427e-03 2.598398e-02 19 5220260 5220353 94 - 2.166 2.131 -0.115
ENSG00000105426 E036 257.1618053 0.0014945255 1.700347e-02 8.547104e-02 19 5221000 5221253 254 - 2.372 2.365 -0.025
ENSG00000105426 E037 135.8612946 0.0170123926 6.815313e-01 8.236085e-01 19 5222123 5222220 98 - 2.068 2.102 0.114
ENSG00000105426 E038 224.2437459 0.0138130479 3.594923e-01 5.954303e-01 19 5222689 5223297 609 - 2.222 2.339 0.391
ENSG00000105426 E039 65.8377193 0.0204702527 3.173449e-01 5.573156e-01 19 5225727 5225844 118 - 1.795 1.781 -0.048
ENSG00000105426 E040 0.1426347 0.0312752659 1.648077e-01   19 5229316 5229342 27 - 0.177 0.000 -12.755
ENSG00000105426 E041 63.7307905 0.0088899016 9.513846e-01 9.776787e-01 19 5229491 5229684 194 - 1.722 1.787 0.222
ENSG00000105426 E042 130.8586022 0.0055385649 6.386425e-01 7.961182e-01 19 5231310 5231615 306 - 2.044 2.090 0.155
ENSG00000105426 E043 95.2593825 0.0005833297 8.936602e-01 9.485134e-01 19 5238919 5239063 145 - 1.891 1.961 0.236
ENSG00000105426 E044 54.4326253 0.0006926873 7.255162e-01 8.514519e-01 19 5240199 5240238 40 - 1.667 1.712 0.151
ENSG00000105426 E045 88.9423361 0.0004511665 3.228202e-01 5.621581e-01 19 5240239 5240332 94 - 1.894 1.916 0.075
ENSG00000105426 E046 305.6435206 0.0002372374 1.225304e-11 1.039385e-09 19 5243901 5244482 582 - 2.503 2.417 -0.289
ENSG00000105426 E047 200.7322666 0.0007426137 5.641890e-18 1.299714e-15 19 5245776 5246045 270 - 2.384 2.200 -0.612
ENSG00000105426 E048 0.1723744 0.0317205074 1.000000e+00   19 5256108 5256119 12 - 0.000 0.081 10.136
ENSG00000105426 E049 119.8435884 0.0020901691 2.934278e-09 1.548983e-07 19 5258017 5258127 111 - 2.154 1.981 -0.582
ENSG00000105426 E050 0.4458772 0.0217681645 7.674819e-01   19 5260805 5260822 18 - 0.177 0.150 -0.294
ENSG00000105426 E051 0.3032425 0.0244411696 6.802530e-01   19 5262964 5262972 9 - 0.000 0.150 11.133
ENSG00000105426 E052 161.7838583 0.0083666025 1.996496e-05 3.814705e-04 19 5265008 5265196 189 - 2.273 2.116 -0.523
ENSG00000105426 E053 8.6974561 0.0241085747 7.792387e-01 8.843105e-01 19 5269947 5270089 143 - 0.934 0.954 0.073
ENSG00000105426 E054 14.0304255 0.0251044807 2.459330e-01 4.835321e-01 19 5273061 5273326 266 - 0.981 1.190 0.758
ENSG00000105426 E055 199.2539094 0.0064466707 2.906570e-03 2.283928e-02 19 5273442 5273548 107 - 2.310 2.234 -0.252
ENSG00000105426 E056 145.5316244 0.0052500432 1.548993e-03 1.395442e-02 19 5273549 5273583 35 - 2.180 2.097 -0.277
ENSG00000105426 E057 229.0803867 0.0073429516 3.461933e-03 2.611567e-02 19 5274199 5274344 146 - 2.371 2.295 -0.253
ENSG00000105426 E058 166.2709861 0.0219406566 8.448343e-01 9.220407e-01 19 5286050 5286234 185 - 2.146 2.191 0.153
ENSG00000105426 E059 0.0000000       19 5286235 5286388 154 -      
ENSG00000105426 E060 0.0000000       19 5292731 5292787 57 -      
ENSG00000105426 E061 41.4780751 0.0291140643 1.321427e-01 3.351936e-01 19 5293141 5293262 122 - 1.412 1.640 0.779
ENSG00000105426 E062 23.8840212 0.0164247045 6.367467e-01 7.948651e-01 19 5340664 5340852 189 - 1.273 1.385 0.390