ENSG00000105397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524470 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding retained_intron 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 6.400722 7.939655 4.7118240 2.2215281 1.2165787 -0.7515481 0.10348750 0.09020000 0.1198333 0.029633333 0.824087948 0.006407498   FALSE
ENST00000525621 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding protein_coding 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 17.501445 28.522956 12.9757411 2.5847433 0.3670868 -1.1357009 0.31316667 0.34390000 0.3365333 -0.007366667 1.000000000 0.006407498 FALSE TRUE
ENST00000525976 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding protein_coding 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 5.887441 7.884032 0.9418925 0.9051369 0.1793493 -3.0518918 0.08154167 0.09610000 0.0244000 -0.071700000 0.006407498 0.006407498 FALSE FALSE
ENST00000529412 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding retained_intron 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 5.857418 7.688251 4.5610110 2.2682059 0.6704633 -0.7520174 0.10549167 0.08700000 0.1201667 0.033166667 0.775953348 0.006407498 FALSE TRUE
ENST00000529739 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding retained_intron 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 5.830218 8.261351 4.4506817 2.0674662 0.5911534 -0.8908587 0.10233333 0.09410000 0.1146667 0.020566667 0.829307132 0.006407498 FALSE TRUE
ENST00000530220 ENSG00000105397 HEK293_OSMI2_6hA HEK293_TMG_6hB TYK2 protein_coding retained_intron 58.75792 85.0527 38.76879 8.588935 2.290916 -1.133259 3.280615 5.008394 2.1022259 2.0378059 0.2310056 -1.2484616 0.05411250 0.05693333 0.0539000 -0.003033333 1.000000000 0.006407498 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105397 E001 6.1537214 0.0095346326 2.278374e-01 4.628232e-01 19 10350529 10350532 4 - 0.624 0.859 0.954
ENSG00000105397 E002 13.4483591 0.0218429061 3.347784e-02 1.374126e-01 19 10350533 10350541 9 - 0.837 1.180 1.269
ENSG00000105397 E003 260.2680010 1.0629852949 3.157961e-01 5.557973e-01 19 10350542 10350747 206 - 2.089 2.428 1.130
ENSG00000105397 E004 188.4774835 0.9232649943 2.762379e-01 5.162434e-01 19 10350748 10350787 40 - 1.937 2.290 1.181
ENSG00000105397 E005 199.2889673 0.9721604376 3.118385e-01 5.522092e-01 19 10350788 10350852 65 - 1.988 2.310 1.078
ENSG00000105397 E006 313.1208845 1.2045119562 4.193433e-01 6.431558e-01 19 10350853 10350946 94 - 2.246 2.494 0.826
ENSG00000105397 E007 184.1353946 1.0456568144 4.553464e-01 6.697583e-01 19 10350947 10350968 22 - 2.065 2.254 0.633
ENSG00000105397 E008 16.3887515 0.3441795294 8.762813e-01 9.393734e-01 19 10350969 10351051 83 - 1.220 1.176 -0.159
ENSG00000105397 E009 268.3652047 1.1666177971 4.395147e-01 6.582971e-01 19 10351052 10351162 111 - 2.201 2.422 0.739
ENSG00000105397 E010 22.4279850 0.2491297016 6.235001e-01 7.862356e-01 19 10351163 10351293 131 - 1.236 1.343 0.373
ENSG00000105397 E011 20.0384624 0.1009572618 6.992630e-02 2.246476e-01 19 10351421 10351484 64 - 0.950 1.347 1.425
ENSG00000105397 E012 235.5174111 1.1035872048 4.190288e-01 6.429060e-01 19 10352434 10352551 118 - 2.134 2.368 0.783
ENSG00000105397 E013 197.3350174 1.0359480895 4.134859e-01 6.386519e-01 19 10352926 10353021 96 - 2.059 2.292 0.778
ENSG00000105397 E014 176.8612695 0.9483317617 3.446460e-01 5.821950e-01 19 10353022 10353098 77 - 1.963 2.254 0.974
ENSG00000105397 E015 56.4949538 0.5899714514 7.348281e-01 8.571619e-01 19 10353099 10353256 158 - 1.656 1.721 0.221
ENSG00000105397 E016 174.0772565 0.9409061864 3.395979e-01 5.776338e-01 19 10353528 10353646 119 - 1.957 2.247 0.972
ENSG00000105397 E017 105.2020238 0.7133508328 5.836282e-01 7.593681e-01 19 10353647 10353910 264 - 1.899 1.993 0.316
ENSG00000105397 E018 86.1827901 0.6355046570 5.631048e-01 7.454963e-01 19 10353911 10354041 131 - 1.804 1.911 0.359
ENSG00000105397 E019 316.1695268 1.2408980899 4.748136e-01 6.834252e-01 19 10354042 10354234 193 - 2.289 2.489 0.667
ENSG00000105397 E020 173.4158172 0.0819846690 2.300347e-01 4.651869e-01 19 10354512 10354537 26 - 2.062 2.223 0.539
ENSG00000105397 E021 227.1533742 0.0008729645 1.087455e-01 2.969957e-01 19 10354538 10354609 72 - 2.226 2.332 0.352
ENSG00000105397 E022 261.2050674 0.0008622153 4.385886e-01 6.576931e-01 19 10356568 10356718 151 - 2.306 2.385 0.264
ENSG00000105397 E023 30.8172006 0.1662631923 1.102291e-01 2.993578e-01 19 10356719 10357084 366 - 1.555 1.402 -0.527
ENSG00000105397 E024 28.2703349 0.1764673226 1.575334e-02 8.093853e-02 19 10357385 10357763 379 - 1.635 1.295 -1.171
ENSG00000105397 E025 121.7884683 0.0051920775 5.911316e-01 7.644805e-01 19 10357764 10357793 30 - 2.011 2.041 0.101
ENSG00000105397 E026 202.4069092 0.0041694365 4.769585e-01 6.849421e-01 19 10357794 10357918 125 - 2.187 2.275 0.295
ENSG00000105397 E027 221.5177406 0.0018145547 8.868609e-01 9.450472e-01 19 10358003 10358138 136 - 2.246 2.310 0.214
ENSG00000105397 E028 243.1519229 0.0011162416 2.166697e-01 4.495168e-01 19 10359175 10359302 128 - 2.318 2.342 0.078
ENSG00000105397 E029 5.7733746 0.0049297394 2.948266e-04 3.677710e-03 19 10360962 10361073 112 - 1.048 0.634 -1.625
ENSG00000105397 E030 1.9683145 0.8055940172 4.414001e-01 6.596630e-01 19 10361305 10361510 206 - 0.486 0.419 -0.343
ENSG00000105397 E031 211.1616150 0.0092277365 4.429726e-01 6.607316e-01 19 10361511 10361598 88 - 2.253 2.279 0.088
ENSG00000105397 E032 192.8973951 0.0099638705 3.782091e-01 6.106943e-01 19 10361770 10361836 67 - 2.222 2.238 0.054
ENSG00000105397 E033 250.4463522 0.0099262434 1.710076e-01 3.918851e-01 19 10361837 10361955 119 - 2.352 2.343 -0.029
ENSG00000105397 E034 231.4014752 0.0134545576 2.769550e-01 5.169690e-01 19 10362078 10362181 104 - 2.313 2.311 -0.008
ENSG00000105397 E035 0.8810853 0.0171253653 2.069934e-01   19 10362182 10362183 2 - 0.000 0.295 10.777
ENSG00000105397 E036 313.1742868 0.0143326620 3.197430e-01 5.594794e-01 19 10362264 10362456 193 - 2.438 2.443 0.017
ENSG00000105397 E037 159.4684322 0.0043272506 3.378304e-02 1.382909e-01 19 10362549 10362579 31 - 2.175 2.145 -0.099
ENSG00000105397 E038 190.3557860 0.0090055776 1.561202e-01 3.710887e-01 19 10362580 10362657 78 - 2.234 2.225 -0.031
ENSG00000105397 E039 212.1022812 0.0095422057 8.671252e-01 9.344032e-01 19 10364614 10364771 158 - 2.219 2.292 0.243
ENSG00000105397 E040 211.6660853 0.0138925911 5.295911e-01 7.217671e-01 19 10364851 10365048 198 - 2.255 2.279 0.079
ENSG00000105397 E041 366.3606489 0.0217095331 3.688606e-01 6.031002e-01 19 10365517 10365898 382 - 2.510 2.509 -0.005
ENSG00000105397 E042 271.9646691 0.0290822852 1.060934e-01 2.925091e-01 19 10366417 10366580 164 - 2.434 2.360 -0.248
ENSG00000105397 E043 119.5977822 0.0431394886 7.811544e-02 2.410692e-01 19 10368055 10368062 8 - 2.117 1.988 -0.433
ENSG00000105397 E044 193.5114663 0.0306747525 5.342048e-02 1.877058e-01 19 10368063 10368121 59 - 2.312 2.201 -0.368
ENSG00000105397 E045 155.3338476 0.0160410064 1.764554e-02 8.779756e-02 19 10368122 10368163 42 - 2.209 2.111 -0.326
ENSG00000105397 E046 129.6489210 0.0038487096 1.501211e-03 1.362879e-02 19 10368164 10368202 39 - 2.120 2.039 -0.271
ENSG00000105397 E047 107.9706654 0.0004579894 2.115781e-06 5.482206e-05 19 10368295 10368328 34 - 2.069 1.949 -0.402
ENSG00000105397 E048 140.9543843 0.0098226639 2.089362e-03 1.766512e-02 19 10368329 10368371 43 - 2.178 2.064 -0.381
ENSG00000105397 E049 123.8988155 0.0263292934 7.546401e-02 2.357876e-01 19 10368372 10368418 47 - 2.108 2.015 -0.312
ENSG00000105397 E050 0.4929928 0.0217068028 1.211008e-01   19 10368419 10368531 113 - 0.316 0.077 -2.463
ENSG00000105397 E051 5.9373359 0.0241437042 4.107318e-01 6.365543e-01 19 10368532 10368741 210 - 0.839 0.769 -0.273
ENSG00000105397 E052 4.8288095 0.0695798953 3.003108e-01 5.407435e-01 19 10369757 10369877 121 - 0.805 0.674 -0.536
ENSG00000105397 E053 214.3430514 0.0046390278 3.620340e-03 2.704394e-02 19 10378214 10378426 213 - 2.323 2.263 -0.198
ENSG00000105397 E054 0.4341107 0.0244411696 4.728720e-01   19 10378427 10378508 82 - 0.000 0.199 10.033
ENSG00000105397 E055 153.1619697 0.0098801933 5.484157e-02 1.909806e-01 19 10379615 10379689 75 - 2.167 2.123 -0.150
ENSG00000105397 E056 170.5559334 0.0097320045 5.416643e-03 3.677894e-02 19 10379690 10379779 90 - 2.246 2.155 -0.304
ENSG00000105397 E057 151.1523058 0.0054125337 4.244127e-04 4.971035e-03 19 10380380 10380509 130 - 2.203 2.102 -0.338
ENSG00000105397 E058 33.0777749 0.0181577648 2.939187e-03 2.303057e-02 19 10380510 10380590 81 - 1.621 1.423 -0.678