ENSG00000105323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392006 ENSG00000105323 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPUL1 protein_coding protein_coding 164.4977 199.4697 139.8161 29.74516 9.025174 -0.5126084 63.01792 86.56864 37.73556 15.681195 0.7906677 -1.19770423 0.37535833 0.42910000 0.27163333 -0.157466667 0.003979078 0.003979078 FALSE TRUE
ENST00000595018 ENSG00000105323 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPUL1 protein_coding protein_coding 164.4977 199.4697 139.8161 29.74516 9.025174 -0.5126084 22.75825 25.13956 20.49694 4.602122 2.7038293 -0.29442106 0.13952500 0.12460000 0.14536667 0.020766667 0.756738051 0.003979078 FALSE TRUE
ENST00000599719 ENSG00000105323 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPUL1 protein_coding protein_coding 164.4977 199.4697 139.8161 29.74516 9.025174 -0.5126084 24.33785 18.40378 32.23249 1.218463 4.3659076 0.80817754 0.15175000 0.09523333 0.23253333 0.137300000 0.013070533 0.003979078 FALSE TRUE
ENST00000600596 ENSG00000105323 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPUL1 protein_coding nonsense_mediated_decay 164.4977 199.4697 139.8161 29.74516 9.025174 -0.5126084 11.33230 12.08785 11.38218 2.252404 0.6494448 -0.08670663 0.07107500 0.06153333 0.08200000 0.020466667 0.654232013 0.003979078 FALSE FALSE
MSTRG.17202.8 ENSG00000105323 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPUL1 protein_coding   164.4977 199.4697 139.8161 29.74516 9.025174 -0.5126084 11.57523 14.10743 10.96602 2.631130 0.9796982 -0.36312138 0.07008333 0.07010000 0.07856667 0.008466667 0.868380032 0.003979078 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105323 E001 2.9323175 0.0458776618 2.894941e-01 5.300167e-01 19 41262496 41262518 23 + 0.678 0.507 -0.764
ENSG00000105323 E002 3.1103013 0.1016509643 2.563367e-01 4.951079e-01 19 41262519 41262520 2 + 0.722 0.506 -0.953
ENSG00000105323 E003 5.8999369 0.0364384372 1.289450e-01 3.301363e-01 19 41262521 41262529 9 + 0.952 0.748 -0.789
ENSG00000105323 E004 65.0557230 0.0007054988 1.046427e-02 6.013381e-02 19 41262530 41262582 53 + 1.858 1.756 -0.341
ENSG00000105323 E005 0.6370325 0.0601540890 7.875735e-01   19 41262662 41262670 9 + 0.167 0.222 0.514
ENSG00000105323 E006 8.1878951 0.0039339697 3.746761e-01 6.078763e-01 19 41262671 41262981 311 + 0.850 0.976 0.476
ENSG00000105323 E007 1.6720914 0.0205502224 3.460029e-01 5.835766e-01 19 41262982 41263016 35 + 0.287 0.476 1.091
ENSG00000105323 E008 84.9825041 0.0047205857 3.809294e-04 4.547668e-03 19 41264138 41264371 234 + 2.012 1.850 -0.545
ENSG00000105323 E009 70.7186399 0.0022119183 3.373561e-01 5.757178e-01 19 41264372 41264410 39 + 1.781 1.849 0.231
ENSG00000105323 E010 87.5842227 0.0099751652 5.703095e-01 7.504740e-01 19 41264411 41264421 11 + 1.878 1.934 0.186
ENSG00000105323 E011 99.9988118 0.0143699041 7.296480e-01 8.540404e-01 19 41264422 41264426 5 + 1.944 1.985 0.138
ENSG00000105323 E012 125.2156455 0.0101127687 8.501540e-01 9.250702e-01 19 41264427 41264433 7 + 2.050 2.079 0.098
ENSG00000105323 E013 196.3642530 0.0053639811 8.837797e-02 2.607608e-01 19 41264434 41264450 17 + 2.196 2.294 0.328
ENSG00000105323 E014 541.6799812 0.0054636620 1.301665e-03 1.217787e-02 19 41264451 41264605 155 + 2.597 2.746 0.498
ENSG00000105323 E015 565.3234759 0.0059790380 1.500862e-03 1.362708e-02 19 41264606 41264692 87 + 2.613 2.765 0.507
ENSG00000105323 E016 341.6131705 0.0077847160 1.262413e-03 1.187804e-02 19 41264693 41264734 42 + 2.376 2.553 0.592
ENSG00000105323 E017 381.9562589 0.0030789040 8.612876e-04 8.781607e-03 19 41264735 41264798 64 + 2.457 2.591 0.447
ENSG00000105323 E018 16.9940410 0.0179661960 7.759318e-02 2.400245e-01 19 41264847 41265078 232 + 1.334 1.164 -0.600
ENSG00000105323 E019 19.5392389 0.0310549416 5.614539e-01 7.442750e-01 19 41265079 41265100 22 + 1.317 1.261 -0.195
ENSG00000105323 E020 28.3977329 0.0138910266 9.812915e-01 9.924182e-01 19 41265101 41265121 21 + 1.427 1.443 0.053
ENSG00000105323 E021 3.0430332 0.0161707057 9.745143e-01 9.891012e-01 19 41265122 41265167 46 + 0.581 0.590 0.040
ENSG00000105323 E022 19.8396040 0.0049830519 3.718802e-01 6.055422e-01 19 41265168 41265343 176 + 1.216 1.310 0.332
ENSG00000105323 E023 12.5049494 0.1444828806 4.344085e-01 6.545517e-01 19 41268078 41268222 145 + 1.177 1.059 -0.424
ENSG00000105323 E024 881.3892376 0.0032674840 6.810586e-02 2.208168e-01 19 41268223 41268298 76 + 2.941 2.902 -0.127
ENSG00000105323 E025 963.4940352 0.0042755672 1.772163e-03 1.551549e-02 19 41268299 41268345 47 + 3.012 2.923 -0.297
ENSG00000105323 E026 914.4656730 0.0023394843 1.113229e-05 2.301861e-04 19 41272082 41272117 36 + 2.996 2.897 -0.329
ENSG00000105323 E027 1493.3054230 0.0007873863 8.973307e-08 3.367677e-06 19 41272118 41272235 118 + 3.189 3.120 -0.231
ENSG00000105323 E028 3.1242653 0.0080657153 9.809884e-01 9.922760e-01 19 41272236 41272370 135 + 0.580 0.591 0.046
ENSG00000105323 E029 988.1911215 0.0010962765 1.677095e-04 2.308574e-03 19 41273982 41274032 51 + 3.002 2.945 -0.191
ENSG00000105323 E030 825.1861912 0.0015323648 9.677098e-07 2.760151e-05 19 41274033 41274055 23 + 2.948 2.853 -0.315
ENSG00000105323 E031 1351.6997756 0.0011531697 9.869460e-05 1.478791e-03 19 41276159 41276269 111 + 3.137 3.081 -0.186
ENSG00000105323 E032 836.1623016 0.0007794021 2.264617e-06 5.820858e-05 19 41276270 41276298 29 + 2.939 2.869 -0.232
ENSG00000105323 E033 0.5061644 0.4611859440 9.540780e-01   19 41276299 41276808 510 + 0.167 0.163 -0.046
ENSG00000105323 E034 0.0000000       19 41278339 41278443 105 +      
ENSG00000105323 E035 1264.9389777 0.0004930493 1.998639e-07 6.890274e-06 19 41279077 41279176 100 + 3.110 3.052 -0.192
ENSG00000105323 E036 3.5118232 0.0142181908 6.406914e-01 7.973771e-01 19 41280925 41281162 238 + 0.676 0.614 -0.265
ENSG00000105323 E037 1411.2747472 0.0020413582 1.819471e-04 2.471048e-03 19 41281163 41281275 113 + 3.164 3.096 -0.227
ENSG00000105323 E038 0.0000000       19 41291879 41291884 6 +      
ENSG00000105323 E039 2534.3209987 0.0033398121 2.121072e-03 1.788071e-02 19 41292245 41292511 267 + 3.416 3.351 -0.216
ENSG00000105323 E040 1374.7469541 0.0004659654 1.951560e-01 4.235721e-01 19 41294338 41294460 123 + 3.107 3.107 -0.001
ENSG00000105323 E041 1492.2773809 0.0130375734 2.245811e-01 4.589038e-01 19 41294558 41294686 129 + 3.090 3.166 0.251
ENSG00000105323 E042 5.8969450 0.0744651931 9.073359e-01 9.557827e-01 19 41298490 41298909 420 + 0.820 0.815 -0.021
ENSG00000105323 E043 1934.8758430 0.1737698035 3.342750e-01 5.728718e-01 19 41301536 41301704 169 + 3.172 3.290 0.393
ENSG00000105323 E044 17.2804978 0.1004692117 4.935341e-01 6.962985e-01 19 41302393 41302664 272 + 1.144 1.268 0.440
ENSG00000105323 E045 2119.2197950 0.0528694942 2.183733e-01 4.514692e-01 19 41302665 41302949 285 + 3.211 3.330 0.395
ENSG00000105323 E046 1377.9735510 0.0033520856 1.358046e-02 7.268666e-02 19 41303972 41304261 290 + 3.042 3.137 0.316
ENSG00000105323 E047 70.9745014 0.0216699919 8.805600e-01 9.415522e-01 19 41305646 41305675 30 + 1.826 1.830 0.015
ENSG00000105323 E048 404.4051353 0.0041461845 3.807692e-01 6.128358e-01 19 41305676 41305680 5 + 2.541 2.594 0.178
ENSG00000105323 E049 818.4506617 0.0056062309 3.271039e-02 1.352497e-01 19 41305681 41305831 151 + 2.809 2.913 0.347
ENSG00000105323 E050 439.7818068 0.0039762544 4.754723e-03 3.329943e-02 19 41305832 41305867 36 + 2.528 2.649 0.404
ENSG00000105323 E051 4486.4397623 0.0003260742 5.501067e-15 8.363542e-13 19 41306449 41308826 2378 + 3.556 3.649 0.307