ENSG00000105321

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221922 ENSG00000105321 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC9 protein_coding protein_coding 13.6951 20.81699 9.28529 4.0153 0.6491054 -1.163882 4.0479297 7.041443 1.70956379 1.7456697 0.39866553 -2.0358759 0.27021250 0.32913333 0.18360000 -0.14553333 0.25291109 0.01200973 FALSE TRUE
ENST00000595659 ENSG00000105321 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC9 protein_coding protein_coding 13.6951 20.81699 9.28529 4.0153 0.6491054 -1.163882 1.3060018 1.688247 1.72899843 0.4668697 0.58770782 0.0342100 0.10545833 0.08046667 0.17913333 0.09866667 0.42113553 0.01200973   FALSE
ENST00000599398 ENSG00000105321 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC9 protein_coding protein_coding 13.6951 20.81699 9.28529 4.0153 0.6491054 -1.163882 0.8715558 1.478804 0.67454855 0.0221632 0.05739003 -1.1209293 0.06719167 0.07743333 0.07283333 -0.00460000 1.00000000 0.01200973 FALSE FALSE
ENST00000643617 ENSG00000105321 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC9 protein_coding protein_coding 13.6951 20.81699 9.28529 4.0153 0.6491054 -1.163882 0.6559351 1.502370 0.09154158 0.2703875 0.04804237 -3.8966690 0.03727083 0.07516667 0.01043333 -0.06473333 0.01200973 0.01200973 FALSE TRUE
MSTRG.17395.2 ENSG00000105321 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC9 protein_coding   13.6951 20.81699 9.28529 4.0153 0.6491054 -1.163882 5.4706377 7.295540 3.99985264 1.4415126 0.14798129 -0.8654418 0.41134167 0.34930000 0.43446667 0.08516667 0.50808182 0.01200973 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105321 E001 1.3042373 0.0133591816 0.4043347169   19 47255980 47256358 379 + 0.195 0.360 1.188
ENSG00000105321 E002 0.8397668 0.0209493910 0.8181815376   19 47256388 47256522 135 + 0.195 0.240 0.382
ENSG00000105321 E003 1.2738774 0.0152334427 0.4040054339   19 47256523 47256524 2 + 0.195 0.359 1.187
ENSG00000105321 E004 53.3454928 0.0007999132 0.4919572425 0.695291093 19 47256525 47256609 85 + 1.701 1.665 -0.121
ENSG00000105321 E005 4.3424825 0.0436000463 0.6726667780 0.817996733 19 47257532 47257539 8 + 0.741 0.667 -0.310
ENSG00000105321 E006 12.8040520 0.0203080696 0.6835706123 0.824966685 19 47257540 47257654 115 + 1.127 1.071 -0.203
ENSG00000105321 E007 12.5576257 0.0414446940 0.7801294310 0.884842448 19 47257655 47257909 255 + 1.049 1.075 0.097
ENSG00000105321 E008 2.7464387 0.2544842586 0.9718868549 0.987854423 19 47258089 47258329 241 + 0.514 0.530 0.079
ENSG00000105321 E009 82.9335120 0.0005544734 0.0231608304 0.106463043 19 47258330 47258403 74 + 1.933 1.839 -0.318
ENSG00000105321 E010 111.8118415 0.0004747699 0.0001725876 0.002363657 19 47258559 47258663 105 + 2.086 1.953 -0.447
ENSG00000105321 E011 104.3962278 0.0017552973 0.0278411902 0.120842265 19 47260321 47260422 102 + 2.026 1.939 -0.293
ENSG00000105321 E012 116.7982058 0.0016102709 0.1585760079 0.374634523 19 47260588 47260839 252 + 1.961 2.022 0.203
ENSG00000105321 E013 65.6616902 0.0007055006 0.0859862378 0.256390084 19 47264603 47264686 84 + 1.691 1.782 0.309
ENSG00000105321 E014 78.9717219 0.0054501948 0.3510037978 0.588127810 19 47264773 47264946 174 + 1.797 1.858 0.206
ENSG00000105321 E015 5.9091465 0.0056220318 0.0619799357 0.207229852 19 47266295 47266610 316 + 0.951 0.703 -0.969
ENSG00000105321 E016 94.3839385 0.0008077356 0.0027390770 0.021800547 19 47266611 47266792 182 + 1.812 1.947 0.456
ENSG00000105321 E017 64.7438669 0.0007618661 0.2612572137 0.500297540 19 47270407 47270453 47 + 1.710 1.770 0.202
ENSG00000105321 E018 113.4283378 0.0003859424 0.4273537130 0.648983557 19 47270553 47270688 136 + 1.972 2.004 0.109
ENSG00000105321 E019 112.7585338 0.0004961525 0.7608358105 0.873068452 19 47271082 47271187 106 + 1.987 2.001 0.045
ENSG00000105321 E020 130.7335932 0.0004373837 0.2770645443 0.517082698 19 47271274 47271403 130 + 2.030 2.071 0.136
ENSG00000105321 E021 137.4161652 0.0004494848 0.4027475473 0.630569588 19 47271404 47271649 246 + 2.057 2.088 0.103
ENSG00000105321 E022 34.5543264 0.0034482726 0.0236034235 0.107849642 19 47271650 47271953 304 + 1.351 1.525 0.600
ENSG00000105321 E023 50.9368340 0.0008683576 0.0526165900 0.185790060 19 47272069 47272161 93 + 1.729 1.627 -0.347
ENSG00000105321 E024 43.2134270 0.0009306210 0.8108358114 0.902746094 19 47273357 47273406 50 + 1.596 1.583 -0.043
ENSG00000105321 E025 9.6397174 0.2495577286 0.2145481996 0.446981119 19 47273407 47273701 295 + 0.789 1.011 0.844
ENSG00000105321 E026 67.4042116 0.0006304294 0.0125578146 0.068669685 19 47273966 47274313 348 + 1.859 1.744 -0.388