ENSG00000105298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000248420 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding protein_coding 28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 0.3068901 0.000000 1.567242 0.0000000 0.83391858 7.3012606 0.01781250 0.00000000 0.09796667 0.09796667 2.146208e-01 7.681572e-07 FALSE TRUE
ENST00000429344 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding protein_coding 28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 20.2053255 30.849480 9.551882 5.4199118 1.19872134 -1.6903472 0.70487083 0.74316667 0.56590000 -0.17726667 8.528261e-02 7.681572e-07 FALSE TRUE
ENST00000587175 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding retained_intron 28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 1.4661822 2.255088 1.686167 0.1794688 0.07430000 -0.4172888 0.05654583 0.05940000 0.10076667 0.04136667 4.147326e-01 7.681572e-07 FALSE TRUE
ENST00000591978 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding retained_intron 28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 1.4843164 1.915753 1.540075 0.2260474 0.04773829 -0.3130847 0.06066667 0.05063333 0.09283333 0.04220000 3.738548e-01 7.681572e-07 FALSE FALSE
ENST00000592721 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding protein_coding 28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 2.1996548 3.307488 0.000000 1.2056153 0.00000000 -8.3739474 0.05837083 0.07553333 0.00000000 -0.07553333 7.681572e-07 7.681572e-07 FALSE TRUE
MSTRG.16167.8 ENSG00000105298 HEK293_OSMI2_6hA HEK293_TMG_6hB CACTIN protein_coding   28.26476 41.22827 16.76053 6.448537 0.9441662 -1.298055 1.3221204 2.071338 1.412249 0.5408024 0.84829006 -0.5493374 0.06082083 0.04900000 0.08546667 0.03646667 1.000000e+00 7.681572e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105298 E001 0.8092192 0.0177659149 3.106621e-01   19 3610645 3610646 2 - 0.000 0.270 10.492
ENSG00000105298 E002 0.8092192 0.0177659149 3.106621e-01   19 3610647 3610649 3 - 0.000 0.270 10.491
ENSG00000105298 E003 1.5050662 0.0130596591 7.461204e-02 2.339993e-01 19 3610650 3610659 10 - 0.000 0.435 11.486
ENSG00000105298 E004 33.8168843 0.0025021528 4.506001e-02 1.677678e-01 19 3610660 3610704 45 - 1.294 1.509 0.747
ENSG00000105298 E005 212.0087408 0.9031087997 4.473896e-01 6.637927e-01 19 3610705 3610966 262 - 2.123 2.275 0.507
ENSG00000105298 E006 93.2024539 0.3716331933 3.548269e-01 5.915918e-01 19 3610967 3610971 5 - 1.777 1.920 0.480
ENSG00000105298 E007 147.1011466 0.4624110639 2.289444e-01 4.639124e-01 19 3610972 3611061 90 - 1.890 2.131 0.808
ENSG00000105298 E008 199.6078761 0.8203238572 3.531640e-01 5.901461e-01 19 3611062 3611228 167 - 2.047 2.258 0.706
ENSG00000105298 E009 200.2472340 0.7972336281 3.247496e-01 5.640135e-01 19 3611229 3611360 132 - 2.021 2.264 0.814
ENSG00000105298 E010 96.0515177 0.2565713738 1.101375e-01 2.992239e-01 19 3611361 3611364 4 - 1.640 1.958 1.073
ENSG00000105298 E011 254.1958075 0.9060774537 3.446238e-01 5.821708e-01 19 3611365 3611567 203 - 2.129 2.366 0.795
ENSG00000105298 E012 348.7935440 1.0834052516 4.258047e-01 6.478833e-01 19 3611568 3611899 332 - 2.310 2.496 0.617
ENSG00000105298 E013 95.4468776 0.3836379074 3.572282e-01 5.934456e-01 19 3611900 3611903 4 - 1.788 1.930 0.477
ENSG00000105298 E014 532.7613735 1.3008389057 5.201116e-01 7.150355e-01 19 3611904 3612413 510 - 2.543 2.669 0.421
ENSG00000105298 E015 193.8839463 0.7870724851 3.245126e-01 5.638131e-01 19 3613058 3613365 308 - 2.013 2.249 0.791
ENSG00000105298 E016 66.5714692 0.1332460527 7.681685e-02 2.384178e-01 19 3613464 3613506 43 - 1.503 1.799 1.008
ENSG00000105298 E017 87.6046205 0.2721669958 1.800863e-01 4.041333e-01 19 3613507 3613586 80 - 1.665 1.909 0.824
ENSG00000105298 E018 10.6271995 0.0866277158 6.409187e-01 7.974731e-01 19 3614386 3614396 11 - 0.937 1.014 0.287
ENSG00000105298 E019 51.3901309 0.0225004083 6.901523e-02 2.227996e-01 19 3614397 3614409 13 - 1.478 1.678 0.683
ENSG00000105298 E020 136.4153562 0.0003458018 3.924090e-01 6.223217e-01 19 3614410 3614494 85 - 2.044 2.068 0.081
ENSG00000105298 E021 180.5756809 0.0359930969 1.940416e-01 4.221787e-01 19 3614495 3614589 95 - 2.209 2.168 -0.136
ENSG00000105298 E022 97.0033738 0.1140414443 8.714275e-03 5.254711e-02 19 3614590 3616692 2103 - 2.160 1.803 -1.198
ENSG00000105298 E023 219.5034690 0.0476201501 1.815790e-01 4.060825e-01 19 3618875 3618989 115 - 2.309 2.247 -0.206
ENSG00000105298 E024 245.1000429 0.0471868057 1.360373e-01 3.414011e-01 19 3619080 3619242 163 - 2.366 2.291 -0.250
ENSG00000105298 E025 260.5100401 0.0576391089 1.170538e-01 3.109397e-01 19 3620127 3620272 146 - 2.410 2.312 -0.327
ENSG00000105298 E026 213.6838949 0.0438117951 1.035572e-02 5.965773e-02 19 3620707 3620802 96 - 2.387 2.202 -0.617
ENSG00000105298 E027 22.1448268 0.0090579775 3.894078e-06 9.287977e-05 19 3620803 3621028 226 - 1.533 1.185 -1.211
ENSG00000105298 E028 355.1441772 0.0628935512 1.137000e-01 3.052980e-01 19 3623688 3624162 475 - 2.544 2.446 -0.327
ENSG00000105298 E029 147.6417637 0.0683872668 7.583210e-01 8.715832e-01 19 3626596 3626815 220 - 2.054 2.100 0.154