ENSG00000105290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000588808 ENSG00000105290 HEK293_OSMI2_6hA HEK293_TMG_6hB APLP1 protein_coding protein_coding 16.15806 24.35863 7.969884 1.309344 1.322216 -1.610585 1.500399 2.613907 0.572941 0.5196925 0.5729410 -2.170295 0.08542917 0.1091000 0.05416667 -0.05493333 4.500447e-01 2.187861e-12 FALSE FALSE
ENST00000652533 ENSG00000105290 HEK293_OSMI2_6hA HEK293_TMG_6hB APLP1 protein_coding protein_coding 16.15806 24.35863 7.969884 1.309344 1.322216 -1.610585 6.280152 8.841069 3.352047 0.6161117 0.2928490 -1.396512 0.39941667 0.3623667 0.45216667 0.08980000 8.402647e-01 2.187861e-12 FALSE TRUE
MSTRG.17000.2 ENSG00000105290 HEK293_OSMI2_6hA HEK293_TMG_6hB APLP1 protein_coding   16.15806 24.35863 7.969884 1.309344 1.322216 -1.610585 2.137400 3.579719 0.000000 0.5836988 0.0000000 -8.487727 0.12156250 0.1455000 0.00000000 -0.14550000 2.187861e-12 2.187861e-12 FALSE TRUE
MSTRG.17000.9 ENSG00000105290 HEK293_OSMI2_6hA HEK293_TMG_6hB APLP1 protein_coding   16.15806 24.35863 7.969884 1.309344 1.322216 -1.610585 4.388160 7.198508 2.569927 0.2411194 0.2495662 -1.482370 0.27355000 0.2963000 0.33316667 0.03686667 9.008894e-01 2.187861e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105290 E001 0.1308682 0.0309315218 1.0000000000   19 35867899 35868273 375 + 0.000 0.065 9.808
ENSG00000105290 E002 1.1428216 0.0139351511 0.1602236008   19 35868552 35868562 11 + 0.000 0.328 13.251
ENSG00000105290 E003 2.4468713 0.0098069282 0.0194599419 0.094042327 19 35868563 35868573 11 + 0.000 0.534 14.340
ENSG00000105290 E004 6.0237002 0.0093359825 0.0001038611 0.001544078 19 35868574 35868595 22 + 0.000 0.852 15.656
ENSG00000105290 E005 27.6217303 0.0014723934 0.0001953744 0.002624304 19 35868596 35868783 188 + 1.054 1.415 1.276
ENSG00000105290 E006 0.0000000       19 35869473 35869666 194 +      
ENSG00000105290 E007 32.8672514 0.0011053343 0.1902848566 0.417303682 19 35869667 35869748 82 + 1.348 1.451 0.357
ENSG00000105290 E008 37.1713032 0.0011074120 0.6729338513 0.818188392 19 35869749 35869810 62 + 1.458 1.489 0.106
ENSG00000105290 E009 0.0000000       19 35870184 35870226 43 +      
ENSG00000105290 E010 0.6783511 0.0193874923 0.4126934398   19 35870227 35870250 24 + 0.000 0.216 12.450
ENSG00000105290 E011 0.1308682 0.0309315218 1.0000000000   19 35870251 35870268 18 + 0.000 0.065 10.454
ENSG00000105290 E012 1.8077115 0.0151856022 0.2876806090 0.528400846 19 35870269 35870301 33 + 0.554 0.359 -1.002
ENSG00000105290 E013 3.6601872 0.0475830770 0.1478549152 0.359215526 19 35870454 35870895 442 + 0.790 0.548 -1.028
ENSG00000105290 E014 79.8300974 0.0004915906 0.9413496604 0.972876229 19 35870896 35871028 133 + 1.808 1.812 0.015
ENSG00000105290 E015 99.6526627 0.0005269762 0.2131008105 0.445382850 19 35871237 35871349 113 + 1.951 1.899 -0.174
ENSG00000105290 E016 126.3481086 0.0012627297 0.3661210647 0.600865676 19 35871612 35871745 134 + 2.039 2.004 -0.118
ENSG00000105290 E017 175.7010674 0.0003179076 0.4527852912 0.667743267 19 35871858 35872036 179 + 2.170 2.147 -0.077
ENSG00000105290 E018 177.3579378 0.0022906506 0.1138444450 0.305527889 19 35872483 35872613 131 + 2.199 2.140 -0.196
ENSG00000105290 E019 89.6808329 0.0099931306 0.5267627486 0.719664290 19 35873639 35873645 7 + 1.892 1.848 -0.147
ENSG00000105290 E020 134.4457083 0.0004566852 0.8989723444 0.951333627 19 35873646 35873713 68 + 2.029 2.034 0.018
ENSG00000105290 E021 67.5561974 0.0005782361 0.9386297674 0.971630996 19 35874504 35874507 4 + 1.737 1.742 0.017
ENSG00000105290 E022 147.9318049 0.0003392490 0.0571250718 0.196319886 19 35874508 35874662 155 + 2.018 2.088 0.237
ENSG00000105290 E023 134.9879500 0.0021175247 0.1115250808 0.301565566 19 35874741 35874869 129 + 1.978 2.047 0.229
ENSG00000105290 E024 117.4417835 0.0023700747 0.5696228831 0.749984080 19 35876517 35876616 100 + 1.954 1.978 0.082
ENSG00000105290 E025 140.1201066 0.0004929359 0.6649367691 0.812987731 19 35877718 35877825 108 + 2.039 2.055 0.054
ENSG00000105290 E026 17.6419900 0.0220678277 0.7956525707 0.893828845 19 35878082 35878084 3 + 1.199 1.163 -0.128
ENSG00000105290 E027 72.1781962 0.0007841527 0.5728391997 0.752246514 19 35878085 35878108 24 + 1.790 1.761 -0.097
ENSG00000105290 E028 1.9760218 0.0099216569 0.0226963308 0.104956203 19 35878518 35878524 7 + 0.688 0.294 -1.998
ENSG00000105290 E029 4.7065125 0.0059687158 0.0295612172 0.126070281 19 35878525 35878583 59 + 0.908 0.592 -1.287
ENSG00000105290 E030 109.7784990 0.0032580426 0.6849272776 0.825875515 19 35878584 35878654 71 + 1.966 1.944 -0.071
ENSG00000105290 E031 93.3602860 0.0036110549 0.3119368259 0.552296255 19 35878890 35878952 63 + 1.921 1.869 -0.174
ENSG00000105290 E032 105.7177966 0.0012555407 0.3164567162 0.556474233 19 35879074 35879217 144 + 1.898 1.944 0.157
ENSG00000105290 E033 0.3032425 0.0244411696 1.0000000000   19 35879227 35879240 14 + 0.000 0.121 11.452
ENSG00000105290 E034 148.7488618 0.0011079635 0.6947667212 0.832133444 19 35879343 35879947 605 + 2.092 2.079 -0.043