ENSG00000105287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291281 ENSG00000105287 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD2 protein_coding protein_coding 22.95651 32.99449 12.46342 4.818881 0.03924116 -1.403805 2.253246 3.215573 1.9576793 0.3297761 0.1420631 -0.7130604 0.12050417 0.10226667 0.15710000 0.05483333 4.660115e-01 4.799089e-10 FALSE TRUE
ENST00000433867 ENSG00000105287 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD2 protein_coding protein_coding 22.95651 32.99449 12.46342 4.818881 0.03924116 -1.403805 2.255933 5.090355 0.9311934 1.0508027 0.4677428 -2.4380344 0.08369583 0.15250000 0.07463333 -0.07786667 7.351821e-01 4.799089e-10 FALSE TRUE
ENST00000597589 ENSG00000105287 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD2 protein_coding retained_intron 22.95651 32.99449 12.46342 4.818881 0.03924116 -1.403805 10.126389 13.327816 5.7732157 2.9594302 0.1730033 -1.2055786 0.44016667 0.39326667 0.46320000 0.06993333 7.003506e-01 4.799089e-10 FALSE TRUE
ENST00000602155 ENSG00000105287 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD2 protein_coding retained_intron 22.95651 32.99449 12.46342 4.818881 0.03924116 -1.403805 2.784044 3.212306 0.0000000 0.6405421 0.0000000 -8.3319499 0.07751667 0.10000000 0.00000000 -0.10000000 4.799089e-10 4.799089e-10 FALSE TRUE
MSTRG.17372.6 ENSG00000105287 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD2 protein_coding   22.95651 32.99449 12.46342 4.818881 0.03924116 -1.403805 1.921109 3.122162 0.8728281 1.5704814 0.5483164 -1.8269545 0.10051250 0.08283333 0.06983333 -0.01300000 9.980629e-01 4.799089e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105287 E001 2.9638451 0.0080495258 3.963059e-02 0.1537871335 19 46674275 46674313 39 - 0.756 0.443 -1.407
ENSG00000105287 E002 2.1186565 0.0095236162 1.482481e-02 0.0774096168 19 46674314 46674315 2 - 0.709 0.315 -1.950
ENSG00000105287 E003 2.1186565 0.0095236162 1.482481e-02 0.0774096168 19 46674316 46674316 1 - 0.709 0.315 -1.950
ENSG00000105287 E004 5.0423326 0.0069316560 2.379019e-01 0.4741482124 19 46674317 46674318 2 - 0.837 0.689 -0.596
ENSG00000105287 E005 5.9931911 0.0058484633 8.906271e-01 0.9469869528 19 46674319 46674319 1 - 0.756 0.799 0.174
ENSG00000105287 E006 9.7532037 0.0171066074 6.599909e-01 0.8099905464 19 46674320 46674338 19 - 0.992 0.966 -0.097
ENSG00000105287 E007 12.6835143 0.0068956348 7.013571e-01 0.8364851630 19 46674339 46674345 7 - 1.017 1.089 0.263
ENSG00000105287 E008 93.7889687 0.0097642407 3.397591e-01 0.5777691462 19 46674346 46674507 162 - 1.926 1.900 -0.087
ENSG00000105287 E009 208.5266997 0.0006767127 3.037446e-03 0.0236347387 19 46674508 46674735 228 - 2.156 2.276 0.401
ENSG00000105287 E010 174.8315689 0.0380181570 6.275186e-02 0.2089305077 19 46675033 46675118 86 - 2.027 2.205 0.594
ENSG00000105287 E011 1.4643678 0.0379259129 9.023888e-01 0.9530602632 19 46678366 46678395 30 - 0.337 0.381 0.257
ENSG00000105287 E012 197.2527061 1.0428497644 4.024692e-01 0.6303528442 19 46678396 46678528 133 - 2.047 2.261 0.717
ENSG00000105287 E013 172.3352943 0.9901670790 3.997558e-01 0.6280551221 19 46678529 46678663 135 - 1.991 2.203 0.708
ENSG00000105287 E014 106.6788836 0.0009019424 5.014151e-04 0.0056889243 19 46681650 46681682 33 - 1.813 1.994 0.611
ENSG00000105287 E015 136.1400924 0.0004554288 4.267069e-02 0.1617144676 19 46681683 46681748 66 - 1.985 2.087 0.341
ENSG00000105287 E016 0.1723744 0.0407142145 1.000000e+00   19 46685425 46685521 97 - 0.000 0.071 8.746
ENSG00000105287 E017 0.4646582 0.0217681645 6.391064e-01   19 46685522 46686180 659 - 0.201 0.132 -0.731
ENSG00000105287 E018 216.6153388 0.0008206881 1.044795e-01 0.2897340969 19 46689537 46689698 162 - 2.283 2.261 -0.073
ENSG00000105287 E019 0.3336024 0.0244411696 9.432428e-01   19 46689699 46689709 11 - 0.000 0.132 9.804
ENSG00000105287 E020 181.1889460 0.0007140462 2.719457e-03 0.0216823276 19 46690600 46690706 107 - 2.238 2.170 -0.229
ENSG00000105287 E021 132.4488962 0.0012322901 6.167384e-03 0.0405546185 19 46691735 46691807 73 - 2.111 2.034 -0.257
ENSG00000105287 E022 0.6839606 0.0193874923 8.934423e-01   19 46691808 46691851 44 - 0.201 0.185 -0.144
ENSG00000105287 E023 112.0487773 0.0085389801 2.510284e-01 0.4891051259 19 46691933 46691985 53 - 2.004 1.970 -0.112
ENSG00000105287 E024 225.9289548 0.0039493112 1.372590e-01 0.3433354525 19 46693875 46694133 259 - 2.303 2.274 -0.095
ENSG00000105287 E025 114.8812950 0.0003582462 2.491452e-01 0.4869230804 19 46697157 46697234 78 - 2.006 1.987 -0.063
ENSG00000105287 E026 19.6826438 0.0020606937 9.493977e-04 0.0094975003 19 46697235 46697341 107 - 1.429 1.180 -0.869
ENSG00000105287 E027 96.9925232 0.0004186747 2.656431e-01 0.5050347071 19 46697733 46697839 107 - 1.935 1.914 -0.071
ENSG00000105287 E028 56.4542460 0.0007220624 1.805032e-01 0.4046312364 19 46697840 46697850 11 - 1.722 1.674 -0.161
ENSG00000105287 E029 131.2968275 0.0033545781 5.965414e-01 0.7680141894 19 46700799 46700952 154 - 2.045 2.045 0.000
ENSG00000105287 E030 96.4339632 0.0074017535 5.810226e-01 0.7578242776 19 46701035 46701112 78 - 1.868 1.923 0.185
ENSG00000105287 E031 125.3718222 0.0070235962 6.066736e-01 0.7746834569 19 46704169 46704336 168 - 2.029 2.024 -0.014
ENSG00000105287 E032 70.9313035 0.0007927464 4.256576e-01 0.6477570720 19 46704337 46704391 55 - 1.797 1.783 -0.049
ENSG00000105287 E033 0.0000000       19 46704487 46704494 8 -      
ENSG00000105287 E034 97.6668897 0.0131823371 9.473655e-01 0.9759799783 19 46704495 46704633 139 - 1.904 1.923 0.063
ENSG00000105287 E035 51.6452883 0.0105909517 5.132986e-01 0.7104485572 19 46704634 46704649 16 - 1.669 1.641 -0.095
ENSG00000105287 E036 2.3433081 0.0406506728 2.981658e-01 0.5386460203 19 46710354 46710906 553 - 0.595 0.416 -0.869
ENSG00000105287 E037 92.1017008 0.0098823550 9.203761e-01 0.9624151714 19 46710907 46711038 132 - 1.868 1.900 0.108
ENSG00000105287 E038 77.0955448 0.0071325311 6.376590e-01 0.7954938261 19 46713863 46714001 139 - 1.776 1.829 0.177
ENSG00000105287 E039 4.3859618 0.1715502019 7.353791e-02 0.2318468056 19 46714002 46714324 323 - 0.904 0.555 -1.437
ENSG00000105287 E040 1.8187380 0.4021759999 1.585359e-01 0.3745764900 19 46714410 46714599 190 - 0.651 0.284 -1.909
ENSG00000105287 E041 36.9809906 0.0016601448 8.939094e-01 0.9486594468 19 46716131 46716164 34 - 1.499 1.514 0.052
ENSG00000105287 E042 43.7539621 0.0019760060 9.820619e-01 0.9927761165 19 46716165 46716220 56 - 1.559 1.585 0.089
ENSG00000105287 E043 34.5421709 0.0057975222 1.240701e-01 0.3221657243 19 46716221 46716259 39 - 1.357 1.505 0.513
ENSG00000105287 E044 67.1358620 0.0013372288 7.668259e-02 0.2381403716 19 46716260 46716535 276 - 1.659 1.781 0.413
ENSG00000105287 E045 30.4712377 0.0013949255 4.944046e-06 0.0001140313 19 46716536 46716814 279 - 1.630 1.347 -0.973
ENSG00000105287 E046 42.5334443 0.0040100765 1.127823e-03 0.0108743664 19 46716815 46716950 136 - 1.706 1.517 -0.644
ENSG00000105287 E047 33.7609003 0.0012484249 6.679682e-01 0.8149105335 19 46716951 46717177 227 - 1.474 1.468 -0.021
ENSG00000105287 E048 3.5157226 0.0469654329 4.820897e-02 0.1754869344 19 46717799 46717976 178 - 0.835 0.516 -1.356
ENSG00000105287 E049 4.5739993 0.0072046297 8.286397e-03 0.0506400586 19 46718353 46718417 65 - 0.936 0.583 -1.432