ENSG00000105202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221801 ENSG00000105202 HEK293_OSMI2_6hA HEK293_TMG_6hB FBL protein_coding protein_coding 946.7887 1211.753 536.5674 271.8897 24.98285 -1.175249 249.21325 451.4460 99.81787 81.17842 8.358402 -2.1770709 0.2752333 0.3836333 0.18586667 -0.1977667 2.034373e-05 2.034373e-05 FALSE TRUE
ENST00000597224 ENSG00000105202 HEK293_OSMI2_6hA HEK293_TMG_6hB FBL protein_coding protein_coding 946.7887 1211.753 536.5674 271.8897 24.98285 -1.175249 189.30733 160.2904 124.70967 48.28615 15.975581 -0.3620893 0.1857333 0.1255667 0.23103333 0.1054667 6.533261e-02 2.034373e-05 FALSE FALSE
MSTRG.17149.11 ENSG00000105202 HEK293_OSMI2_6hA HEK293_TMG_6hB FBL protein_coding   946.7887 1211.753 536.5674 271.8897 24.98285 -1.175249 94.93982 138.6509 46.76949 65.67506 25.251665 -1.5676125 0.0952875 0.1016667 0.09206667 -0.0096000 9.275334e-01 2.034373e-05 FALSE TRUE
MSTRG.17149.12 ENSG00000105202 HEK293_OSMI2_6hA HEK293_TMG_6hB FBL protein_coding   946.7887 1211.753 536.5674 271.8897 24.98285 -1.175249 77.28405 192.3656 65.58079 51.93185 10.739507 -1.5523606 0.1141833 0.1880667 0.12086667 -0.0672000 8.900120e-01 2.034373e-05 FALSE TRUE
MSTRG.17149.2 ENSG00000105202 HEK293_OSMI2_6hA HEK293_TMG_6hB FBL protein_coding   946.7887 1211.753 536.5674 271.8897 24.98285 -1.175249 308.25720 247.5341 179.99666 99.90798 26.948900 -0.4596350 0.2977500 0.1804333 0.33333333 0.1529000 4.503773e-01 2.034373e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105202 E001 2.374113 4.181028e-01 2.825838e-01 5.229977e-01 19 39834412 39834452 41 - 0.722 0.371 -1.661
ENSG00000105202 E002 9.755129 7.624208e-02 8.173560e-01 9.065819e-01 19 39834453 39834457 5 - 0.990 0.988 -0.007
ENSG00000105202 E003 55.911536 2.319881e-02 8.280493e-03 5.061616e-02 19 39834458 39834459 2 - 1.479 1.750 0.924
ENSG00000105202 E004 864.790250 2.373150e-03 8.188215e-01 9.073422e-01 19 39834460 39834502 43 - 2.859 2.880 0.069
ENSG00000105202 E005 2331.093759 1.510127e-03 8.941968e-02 2.627197e-01 19 39834503 39834562 60 - 3.319 3.299 -0.065
ENSG00000105202 E006 34.121880 1.259180e-03 5.594094e-01 7.429059e-01 19 39834563 39834667 105 - 1.506 1.478 -0.097
ENSG00000105202 E007 2943.547934 1.279081e-03 1.459973e-02 7.659471e-02 19 39834668 39834690 23 - 3.428 3.397 -0.102
ENSG00000105202 E008 3766.656578 3.103703e-04 1.730833e-07 6.068027e-06 19 39834691 39834716 26 - 3.544 3.502 -0.142
ENSG00000105202 E009 6136.152282 2.817512e-04 3.182821e-14 4.331059e-12 19 39834717 39834813 97 - 3.767 3.710 -0.190
ENSG00000105202 E010 7093.536091 8.543580e-05 9.975384e-20 2.809369e-17 19 39836556 39836668 113 - 3.821 3.777 -0.145
ENSG00000105202 E011 6835.654012 3.488978e-04 1.341365e-02 7.207212e-02 19 39837711 39837819 109 - 3.781 3.769 -0.041
ENSG00000105202 E012 3795.342823 9.029414e-04 2.324544e-01 4.680098e-01 19 39837820 39837843 24 - 3.521 3.515 -0.019
ENSG00000105202 E013 16.721970 1.993839e-01 6.884344e-02 2.224734e-01 19 39837959 39838091 133 - 1.438 1.059 -1.338
ENSG00000105202 E014 47.619197 5.876142e-02 2.286613e-03 1.896461e-02 19 39838260 39839034 775 - 1.885 1.488 -1.347
ENSG00000105202 E015 4365.321167 1.047536e-03 8.917577e-01 9.474920e-01 19 39839035 39839073 39 - 3.568 3.580 0.039
ENSG00000105202 E016 7314.766977 9.806100e-04 7.452614e-01 8.638491e-01 19 39839074 39839205 132 - 3.793 3.803 0.032
ENSG00000105202 E017 6019.037682 4.408163e-04 2.583457e-02 1.147674e-01 19 39840233 39840327 95 - 3.725 3.713 -0.038
ENSG00000105202 E018 4179.552821 4.155536e-04 1.880945e-03 1.627160e-02 19 39840414 39840461 48 - 3.522 3.569 0.159
ENSG00000105202 E019 2254.718502 7.788706e-05 3.779354e-08 1.553186e-06 19 39840462 39840470 9 - 3.241 3.307 0.218
ENSG00000105202 E020 2029.856706 6.575624e-05 2.220819e-08 9.645681e-07 19 39840471 39840509 39 - 3.194 3.262 0.226
ENSG00000105202 E021 176.731264 6.731370e-03 7.731677e-02 2.394617e-01 19 39840510 39840515 6 - 2.115 2.211 0.321
ENSG00000105202 E022 119.947210 2.650218e-03 1.790204e-02 8.871347e-02 19 39840617 39840619 3 - 1.931 2.051 0.401
ENSG00000105202 E023 168.434964 5.794646e-02 5.443348e-02 1.901005e-01 19 39840620 39840655 36 - 1.971 2.215 0.819
ENSG00000105202 E024 402.232656 8.100022e-03 5.114968e-05 8.484463e-04 19 39840656 39840670 15 - 2.381 2.585 0.678
ENSG00000105202 E025 412.229469 8.673887e-03 3.156824e-05 5.642736e-04 19 39840671 39840673 3 - 2.383 2.597 0.714
ENSG00000105202 E026 977.364689 6.759092e-03 7.797816e-10 4.643228e-08 19 39840674 39840682 9 - 2.712 2.980 0.892
ENSG00000105202 E027 1589.186821 1.138860e-02 7.701914e-04 8.028248e-03 19 39840683 39840721 39 - 2.996 3.176 0.597
ENSG00000105202 E028 1763.501679 6.220642e-03 5.135873e-04 5.801060e-03 19 39840722 39840727 6 - 3.072 3.214 0.472
ENSG00000105202 E029 2032.655332 8.660360e-03 3.564665e-02 1.433149e-01 19 39840728 39840787 60 - 3.169 3.267 0.326
ENSG00000105202 E030 2024.362479 7.443503e-03 2.288099e-02 1.055533e-01 19 39846291 39846448 158 - 3.166 3.265 0.329