ENSG00000105186

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306065 ENSG00000105186 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD27 protein_coding protein_coding 15.13089 9.867805 20.81768 0.4664518 1.105828 1.076239 11.5031589 7.7518060 15.27817156 0.6013787 0.63150143 0.9779516 0.77012083 0.78620000 0.734866667 -0.051333333 8.096693e-01 9.575831e-18 FALSE TRUE
ENST00000587667 ENSG00000105186 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD27 protein_coding retained_intron 15.13089 9.867805 20.81768 0.4664518 1.105828 1.076239 1.2398084 1.0004228 2.00327056 0.3864009 0.16814463 0.9945820 0.08243333 0.10373333 0.095900000 -0.007833333 1.000000e+00 9.575831e-18   FALSE
ENST00000588700 ENSG00000105186 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD27 protein_coding nonsense_mediated_decay 15.13089 9.867805 20.81768 0.4664518 1.105828 1.076239 1.4277400 0.0000000 2.98064035 0.0000000 0.28638340 8.2243106 0.07248333 0.00000000 0.142633333 0.142633333 9.575831e-18 9.575831e-18   FALSE
MSTRG.16912.1 ENSG00000105186 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD27 protein_coding   15.13089 9.867805 20.81768 0.4664518 1.105828 1.076239 0.4405571 0.7933997 0.05245202 0.3891054 0.05245202 -3.6852979 0.04071250 0.07716667 0.002433333 -0.074733333 3.444952e-02 9.575831e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000105186 E001 0.2735028 0.0264353782 7.362579e-01   19 32596793 32597005 213 - 0.099 0.148 0.661
ENSG00000105186 E002 481.4799927 0.0001389335 3.948209e-12 3.671942e-10 19 32597006 32598327 1322 - 2.625 2.732 0.355
ENSG00000105186 E003 81.9675104 0.0005114961 3.950215e-01 6.243832e-01 19 32598328 32598378 51 - 1.890 1.924 0.112
ENSG00000105186 E004 101.8360798 0.0010503867 2.660895e-01 5.055673e-01 19 32599704 32599776 73 - 1.979 2.020 0.140
ENSG00000105186 E005 98.2794859 0.0004860395 7.718614e-01 8.797362e-01 19 32599972 32600050 79 - 1.978 1.988 0.033
ENSG00000105186 E006 12.6652723 0.1484277122 9.450525e-01 9.748016e-01 19 32600051 32600286 236 - 1.098 1.164 0.237
ENSG00000105186 E007 89.5261412 0.0005176896 2.324069e-01 4.679750e-01 19 32602015 32602126 112 - 1.925 1.969 0.150
ENSG00000105186 E008 90.8181849 0.0022217595 2.944492e-01 5.350280e-01 19 32604263 32604424 162 - 1.933 1.978 0.148
ENSG00000105186 E009 75.2836540 0.0009438782 5.992051e-02 2.026341e-01 19 32605835 32605954 120 - 1.838 1.917 0.265
ENSG00000105186 E010 90.7627781 0.0005076311 8.947184e-04 9.051275e-03 19 32607635 32607832 198 - 1.895 2.019 0.419
ENSG00000105186 E011 75.1489314 0.0006291784 9.233583e-02 2.680653e-01 19 32615658 32615780 123 - 1.837 1.907 0.234
ENSG00000105186 E012 55.6306593 0.0007339066 3.767933e-01 6.096871e-01 19 32617589 32617633 45 - 1.721 1.762 0.142
ENSG00000105186 E013 84.6296484 0.0005822046 5.648393e-01 7.466719e-01 19 32619260 32619379 120 - 1.910 1.932 0.074
ENSG00000105186 E014 57.6881231 0.0036781687 1.443743e-01 3.539630e-01 19 32619494 32619553 60 - 1.721 1.801 0.270
ENSG00000105186 E015 101.3631993 0.0008060531 6.001748e-01 7.703242e-01 19 32622422 32622619 198 - 1.990 2.009 0.063
ENSG00000105186 E016 73.5036985 0.0143951220 8.604419e-01 9.305768e-01 19 32625874 32625966 93 - 1.867 1.859 -0.030
ENSG00000105186 E017 71.4491501 0.0231170159 7.167203e-01 8.460705e-01 19 32626712 32626806 95 - 1.862 1.839 -0.079
ENSG00000105186 E018 47.3799022 0.0090134855 1.388953e-01 3.458292e-01 19 32626807 32626827 21 - 1.715 1.613 -0.348
ENSG00000105186 E019 66.8388100 0.0119113520 2.930734e-01 5.337902e-01 19 32628083 32628165 83 - 1.851 1.780 -0.241
ENSG00000105186 E020 91.8219016 0.0027057592 1.945233e-01 4.227512e-01 19 32628722 32628849 128 - 1.981 1.923 -0.196
ENSG00000105186 E021 75.0340919 0.0006039130 2.160128e-01 4.486346e-01 19 32631402 32631494 93 - 1.893 1.840 -0.179
ENSG00000105186 E022 10.1841931 0.0137628400 2.187581e-02 1.021619e-01 19 32637300 32639355 2056 - 0.913 1.172 0.946
ENSG00000105186 E023 91.6518686 0.0032288354 5.697541e-01 7.500686e-01 19 32639356 32639488 133 - 1.968 1.943 -0.085
ENSG00000105186 E024 72.4897668 0.0005969385 7.184142e-01 8.472449e-01 19 32640307 32640385 79 - 1.864 1.847 -0.055
ENSG00000105186 E025 77.3820731 0.0013963394 2.731203e-01 5.129969e-01 19 32642024 32642145 122 - 1.899 1.850 -0.164
ENSG00000105186 E026 0.1723744 0.0328488802 3.123020e-01   19 32643063 32643122 60 - 0.000 0.148 9.918
ENSG00000105186 E027 34.1920841 0.0013059724 9.159339e-01 9.601526e-01 19 32643123 32643126 4 - 1.533 1.525 -0.025
ENSG00000105186 E028 61.1861304 0.0025764411 7.532580e-01 8.686841e-01 19 32643127 32643199 73 - 1.783 1.767 -0.055
ENSG00000105186 E029 0.4702677 0.0217681645 8.592152e-01   19 32643200 32643286 87 - 0.180 0.148 -0.342
ENSG00000105186 E030 64.9642944 0.0007039422 5.142743e-01 7.111810e-01 19 32643287 32643352 66 - 1.817 1.786 -0.104
ENSG00000105186 E031 63.5277202 0.0014869791 4.736935e-02 1.734390e-01 19 32643431 32643484 54 - 1.835 1.738 -0.329
ENSG00000105186 E032 68.7069794 0.0008976739 2.736007e-04 3.463562e-03 19 32643572 32643631 60 - 1.890 1.721 -0.571
ENSG00000105186 E033 1.4677596 0.7116588496 8.482052e-01 9.239442e-01 19 32643632 32643785 154 - 0.301 0.492 1.075
ENSG00000105186 E034 75.3962121 0.0006859756 3.150065e-05 5.631682e-04 19 32644325 32644396 72 - 1.936 1.753 -0.618
ENSG00000105186 E035 74.2904274 0.0005462988 1.185905e-04 1.721610e-03 19 32644397 32644476 80 - 1.925 1.756 -0.568
ENSG00000105186 E036 37.2070312 0.0010105569 1.652421e-02 8.372063e-02 19 32644477 32644479 3 - 1.621 1.475 -0.501
ENSG00000105186 E037 71.4205061 0.0005585633 2.215032e-03 1.849287e-02 19 32646459 32646603 145 - 1.897 1.762 -0.457
ENSG00000105186 E038 33.6464798 0.0017396886 2.450081e-01 4.822999e-01 19 32646604 32646615 12 - 1.555 1.480 -0.257
ENSG00000105186 E039 76.7900208 0.0015453368 1.091494e-02 6.200811e-02 19 32649682 32649792 111 - 1.919 1.803 -0.389
ENSG00000105186 E040 66.8501699 0.0007501733 1.629156e-02 8.285959e-02 19 32658914 32659045 132 - 1.858 1.747 -0.374
ENSG00000105186 E041 37.2600077 0.0011137374 2.579087e-01 4.966643e-01 19 32675071 32675192 122 - 1.594 1.525 -0.235
ENSG00000105186 E042 0.0000000       19 32675786 32676597 812 -