ENSG00000104983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536603 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding protein_coding 4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 1.5246977 3.11185698 0.5159806 0.40192406 0.2667679 -2.5693231 0.30342500 0.466466667 0.2600333 -0.20643333 7.332368e-01 4.373382e-06 FALSE TRUE
ENST00000594672 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding protein_coding 4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 0.3905320 0.61058397 0.2293058 0.18639674 0.1295194 -1.3747712 0.09814167 0.091533333 0.1198333 0.02830000 1.000000e+00 4.373382e-06   FALSE
ENST00000595358 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding protein_coding 4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 1.5979001 1.88604364 0.0000000 0.45966038 0.0000000 -7.5668484 0.33914167 0.281133333 0.0000000 -0.28113333 4.373382e-06 4.373382e-06 FALSE TRUE
ENST00000596161 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding retained_intron 4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 0.1533520 0.26592780 0.2315055 0.15095917 0.1773835 -0.1922349 0.04620417 0.039766667 0.1253000 0.08553333 9.128619e-01 4.373382e-06   FALSE
ENST00000601763 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding processed_transcript 4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 0.3929024 0.69972727 0.3305785 0.37994508 0.1962932 -1.0592774 0.09237083 0.105633333 0.1695667 0.06393333 9.679018e-01 4.373382e-06   FALSE
MSTRG.17347.1 ENSG00000104983 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC61 protein_coding   4.462976 6.677959 1.946182 0.09302573 0.1233851 -1.773526 0.1608199 0.03370515 0.5564440 0.03370515 0.1418639 3.6960583 0.05462917 0.004933333 0.2876667 0.28273333 6.685325e-05 4.373382e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104983 E001 0.0000000       19 45995452 45995460 9 +      
ENSG00000104983 E002 0.2617363 0.050753995 1.000000000   19 45995461 45995466 6 + 0.000 0.111 9.394
ENSG00000104983 E003 0.3926045 0.273701801 1.000000000   19 45995467 45995470 4 + 0.000 0.152 9.923
ENSG00000104983 E004 1.2736898 0.013182351 0.170803576   19 45995471 45995478 8 + 0.000 0.337 11.401
ENSG00000104983 E005 14.4788454 0.022745805 0.219216019 0.45245408 19 45995479 45995504 26 + 1.203 1.044 -0.571
ENSG00000104983 E006 2.7431147 0.009132097 0.221965102 0.45585657 19 45996245 45996401 157 + 0.658 0.441 -1.014
ENSG00000104983 E007 0.6370325 0.035716090 0.684726737   19 46003006 46003007 2 + 0.233 0.158 -0.692
ENSG00000104983 E008 29.7417529 0.017931599 0.584830016 0.76020390 19 46003008 46003166 159 + 1.424 1.356 -0.234
ENSG00000104983 E009 1.8968107 0.194051492 0.525159572 0.71854343 19 46003167 46003418 252 + 0.497 0.343 -0.831
ENSG00000104983 E010 21.7092303 0.002397152 0.933906026 0.96906852 19 46003419 46003501 83 + 1.239 1.241 0.008
ENSG00000104983 E011 0.1614157 0.034250760 0.084978413   19 46003502 46003543 42 + 0.233 0.000 -12.990
ENSG00000104983 E012 29.6453184 0.011892889 0.575999229 0.75441779 19 46006559 46006716 158 + 1.333 1.370 0.129
ENSG00000104983 E013 23.8266401 0.001834994 0.857059002 0.92885438 19 46008140 46008301 162 + 1.273 1.285 0.044
ENSG00000104983 E014 12.1749623 0.003002049 0.292888239 0.53356137 19 46015049 46015259 211 + 1.116 0.996 -0.436
ENSG00000104983 E015 0.5171231 0.923265715 1.000000000   19 46015260 46015333 74 + 0.000 0.163 10.037
ENSG00000104983 E016 4.5157667 0.006507310 0.577514132 0.75546470 19 46015345 46015427 83 + 0.721 0.626 -0.401
ENSG00000104983 E017 0.9161448 0.015817046 0.068267378   19 46015428 46015428 1 + 0.496 0.158 -2.279
ENSG00000104983 E018 5.6978317 0.079596760 0.626740399 0.78834269 19 46016054 46016223 170 + 0.655 0.753 0.402
ENSG00000104983 E019 6.1349452 0.004579217 0.453668112 0.66843033 19 46016318 46016393 76 + 0.658 0.776 0.488
ENSG00000104983 E020 15.5567211 0.002329340 0.090359535 0.26442527 19 46016694 46016833 140 + 0.945 1.142 0.720
ENSG00000104983 E021 15.8971609 0.002682820 0.384899539 0.61643965 19 46016991 46017069 79 + 1.039 1.133 0.340
ENSG00000104983 E022 20.9131738 0.005839463 0.748127764 0.86558196 19 46017247 46017304 58 + 1.202 1.229 0.096
ENSG00000104983 E023 24.7367183 0.006383178 0.306638921 0.54727413 19 46018078 46018150 73 + 1.375 1.285 -0.312
ENSG00000104983 E024 26.4313243 0.003901362 0.875367906 0.93893362 19 46018290 46018378 89 + 1.320 1.333 0.045
ENSG00000104983 E025 17.6893094 0.019573350 0.963429111 0.98365561 19 46018379 46018432 54 + 1.162 1.165 0.010
ENSG00000104983 E026 15.8753480 0.002549661 0.038040741 0.14973907 19 46018433 46018522 90 + 0.908 1.155 0.906
ENSG00000104983 E027 9.8588167 0.003711923 0.013814033 0.07359583 19 46018523 46018616 94 + 0.584 0.971 1.556
ENSG00000104983 E028 3.8517703 0.098959545 0.065952834 0.21605614 19 46021082 46021318 237 + 0.868 0.505 -1.534
ENSG00000104983 E029 1.7838864 0.046069972 0.001237616 0.01169917 19 46023373 46023513 141 + 0.778 0.200 -3.096