ENSG00000104870

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221466 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding protein_coding 18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 0.7892752 0.8369281 0.4699370 0.2307502 0.4699370 -0.8193944 0.04325417 0.031833333 0.08336667 0.05153333 7.733545e-01 5.090686e-11 FALSE  
ENST00000426395 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding protein_coding 18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 10.3159237 16.0577914 2.4650261 1.4964153 0.4540524 -2.6986560 0.54372083 0.589966667 0.40870000 -0.18126667 4.797934e-01 5.090686e-11 FALSE  
ENST00000593431 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding retained_intron 18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 0.4271274 0.1544961 0.4009926 0.1544961 0.2059792 1.3210590 0.03250417 0.005633333 0.06150000 0.05586667 4.772856e-01 5.090686e-11 FALSE  
ENST00000596975 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding protein_coding 18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 0.6968200 0.9421188 0.5955513 0.2929377 0.4767655 -0.6528924 0.04323333 0.033066667 0.09946667 0.06640000 9.893338e-01 5.090686e-11 FALSE  
ENST00000600273 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding protein_coding 18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 0.4242568 0.1467771 0.7476969 0.1467771 0.4373239 2.2729057 0.03297917 0.004600000 0.11353333 0.10893333 4.510864e-01 5.090686e-11 FALSE  
MSTRG.17498.10 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding   18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 1.5428520 1.2375279 0.6495841 0.6193938 0.6495841 -0.9194436 0.07533333 0.042066667 0.09070000 0.04863333 8.616079e-01 5.090686e-11 FALSE  
MSTRG.17498.14 ENSG00000104870 HEK293_OSMI2_6hA HEK293_TMG_6hB FCGRT protein_coding   18.92653 27.25899 6.211296 2.728587 0.4792546 -2.131974 1.3468100 2.5076695 0.0000000 0.2266716 0.0000000 -7.9759451 0.05614583 0.092300000 0.00000000 -0.09230000 5.090686e-11 5.090686e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104870 E001 3.1371766 0.0080253812 0.73173615 0.85529775 19 49506816 49506924 109 + 0.427 0.493 0.336
ENSG00000104870 E002 0.0000000       19 49512375 49512514 140 +      
ENSG00000104870 E003 0.8984613 0.0450631693 0.14674237   19 49512635 49512660 26 + 0.427 0.139 -2.157
ENSG00000104870 E004 0.8984613 0.0450631693 0.14674237   19 49512661 49512661 1 + 0.427 0.139 -2.157
ENSG00000104870 E005 2.4506432 0.0090294044 0.46143399 0.67416081 19 49512662 49512750 89 + 0.546 0.396 -0.754
ENSG00000104870 E006 0.0000000       19 49513154 49513176 23 +      
ENSG00000104870 E007 0.0000000       19 49513177 49513178 2 +      
ENSG00000104870 E008 0.5705883 0.2913177940 0.45812951   19 49513179 49513194 16 + 0.266 0.132 -1.250
ENSG00000104870 E009 0.5705883 0.2913177940 0.45812951   19 49513195 49513196 2 + 0.266 0.132 -1.250
ENSG00000104870 E010 16.8175992 0.0076441886 0.26525586 0.50461007 19 49513197 49513243 47 + 0.972 1.113 0.516
ENSG00000104870 E011 21.2167668 0.0017589925 0.37460864 0.60781851 19 49513244 49513254 11 + 1.105 1.198 0.333
ENSG00000104870 E012 60.1641954 0.0006419896 0.02622708 0.11601880 19 49513255 49513378 124 + 1.482 1.633 0.517
ENSG00000104870 E013 23.0814347 0.0019163420 0.32603967 0.56524970 19 49513379 49513386 8 + 1.133 1.233 0.359
ENSG00000104870 E014 25.4720982 0.0045411807 0.37020641 0.60411931 19 49513387 49513389 3 + 1.183 1.274 0.319
ENSG00000104870 E015 26.3835434 0.0022382151 0.27920900 0.51935437 19 49513390 49513394 5 + 1.183 1.289 0.374
ENSG00000104870 E016 28.3778983 0.0015153996 0.33850956 0.57666050 19 49513395 49513397 3 + 1.228 1.316 0.309
ENSG00000104870 E017 30.8085997 0.0012713672 0.86670887 0.93415947 19 49513398 49513403 6 + 1.358 1.337 -0.072
ENSG00000104870 E018 84.6966904 0.0005007830 0.04429912 0.16583654 19 49513404 49513473 70 + 1.665 1.776 0.376
ENSG00000104870 E019 6.0518626 0.0052845014 0.64242228 0.79848117 19 49513474 49513881 408 + 0.639 0.717 0.330
ENSG00000104870 E020 76.1582018 0.0005876335 0.20318240 0.43356216 19 49513882 49513917 36 + 1.657 1.727 0.238
ENSG00000104870 E021 117.6202103 0.0005895030 0.26862682 0.50830116 19 49513918 49514057 140 + 1.949 1.892 -0.192
ENSG00000104870 E022 94.6576160 0.0099024677 0.02356022 0.10772931 19 49514058 49514133 76 + 1.939 1.781 -0.530
ENSG00000104870 E023 4.6812464 0.0081241229 0.58041528 0.75745688 19 49514134 49514210 77 + 0.715 0.613 -0.433
ENSG00000104870 E024 166.8009935 0.0069503000 0.97525803 0.98948138 19 49514211 49514486 276 + 2.059 2.048 -0.037
ENSG00000104870 E025 0.1723744 0.0342473686 0.84241489   19 49515177 49515269 93 + 0.000 0.051 7.794
ENSG00000104870 E026 0.1723744 0.0342473686 0.84241489   19 49516114 49516199 86 + 0.000 0.051 7.794
ENSG00000104870 E027 2.3078160 0.4426878238 0.76982459 0.87855180 19 49520669 49521201 533 + 0.428 0.392 -0.194
ENSG00000104870 E028 3.0708522 0.0108102069 0.03697557 0.14684895 19 49521695 49521813 119 + 0.000 0.541 12.004
ENSG00000104870 E029 90.0980965 0.0005122363 0.01417329 0.07502495 19 49524507 49524570 64 + 1.673 1.807 0.455
ENSG00000104870 E030 166.4489548 0.0004030168 0.42367651 0.64636407 19 49524571 49524776 206 + 2.031 2.055 0.082
ENSG00000104870 E031 23.8057299 0.0365731715 0.01395212 0.07415004 19 49524777 49525456 680 + 1.481 1.177 -1.061
ENSG00000104870 E032 123.7450784 0.0004545541 0.24908454 0.48689293 19 49525457 49525561 105 + 1.977 1.920 -0.190
ENSG00000104870 E033 71.2831409 0.0006709293 0.91234542 0.95830870 19 49525562 49525573 12 + 1.702 1.689 -0.045
ENSG00000104870 E034 1.3982084 0.1614438452 0.33045838 0.56940318 19 49525973 49526009 37 + 0.000 0.305 10.300
ENSG00000104870 E035 191.1847229 0.0006726724 0.03850757 0.15089780 19 49526010 49526428 419 + 2.179 2.098 -0.269