ENSG00000104859

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221455 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding protein_coding 58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 4.531863 5.488672 0.7685631 2.7446043 0.3879146 -2.8201973 0.07791667 0.09936667 0.01310000 -0.08626667 0.83149991 0.04976591 FALSE TRUE
ENST00000391952 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding nonsense_mediated_decay 58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 7.603835 9.166004 6.4893432 0.9853083 0.1161055 -0.4975721 0.13059167 0.14823333 0.11140000 -0.03683333 0.67082346 0.04976591 TRUE TRUE
ENST00000585432 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding retained_intron 58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 8.128967 8.550518 9.6080113 2.0455163 1.0756225 0.1680406 0.13656250 0.13090000 0.16460000 0.03370000 0.73769449 0.04976591   FALSE
ENST00000585615 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding retained_intron 58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 4.502249 3.542236 5.6221152 1.3583108 0.4475764 0.6649495 0.07464167 0.05313333 0.09633333 0.04320000 0.35874077 0.04976591 FALSE FALSE
ENST00000587112 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding nonsense_mediated_decay 58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 9.509396 8.366541 13.8848390 2.2230986 0.8526969 0.7301226 0.16606250 0.12676667 0.23843333 0.11166667 0.04976591 0.04976591 TRUE FALSE
MSTRG.17304.3 ENSG00000104859 HEK293_OSMI2_6hA HEK293_TMG_6hB CLASRP protein_coding   58.4955 63.63788 58.2916 8.532127 0.5975539 -0.126577 7.850567 9.907722 6.6510674 1.6144945 0.9727915 -0.5742554 0.13487917 0.15446667 0.11446667 -0.04000000 0.58006623 0.04976591 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104859 E001 0.1308682 0.0308950013 8.390185e-01   19 45039045 45039045 1 + 0.000 0.093 9.343
ENSG00000104859 E002 0.1308682 0.0308950013 8.390185e-01   19 45039046 45039049 4 + 0.000 0.093 9.348
ENSG00000104859 E003 0.1308682 0.0308950013 8.390185e-01   19 45039050 45039050 1 + 0.000 0.093 9.348
ENSG00000104859 E004 0.4397201 0.0853085569 1.000000e+00   19 45039051 45039052 2 + 0.158 0.168 0.108
ENSG00000104859 E005 0.6120945 0.0187882866 6.754037e-01   19 45039053 45039053 1 + 0.157 0.234 0.709
ENSG00000104859 E006 2.5647710 0.0168137831 8.343259e-01 9.162035e-01 19 45039054 45039060 7 + 0.559 0.529 -0.141
ENSG00000104859 E007 10.1099898 0.0030086308 6.293144e-01 7.900488e-01 19 45039061 45039064 4 + 1.060 1.013 -0.173
ENSG00000104859 E008 39.4646211 0.0134556315 1.956714e-01 4.241811e-01 19 45039065 45039073 9 + 1.519 1.620 0.343
ENSG00000104859 E009 78.4384722 0.0005647894 7.491074e-01 8.662436e-01 19 45039074 45039108 35 + 1.869 1.885 0.057
ENSG00000104859 E010 1.7012339 0.0117428099 4.867142e-01 6.917231e-01 19 45039521 45039917 397 + 0.503 0.385 -0.612
ENSG00000104859 E011 2.0916932 0.0164786541 6.298830e-02 2.094303e-01 19 45039918 45040183 266 + 0.652 0.341 -1.550
ENSG00000104859 E012 146.7576281 0.0003092260 5.111731e-03 3.520662e-02 19 45040184 45040269 86 + 2.201 2.120 -0.272
ENSG00000104859 E013 153.8410760 0.0003077078 4.094747e-03 2.969942e-02 19 45040270 45040311 42 + 2.222 2.141 -0.272
ENSG00000104859 E014 7.2293693 0.2064845678 8.426686e-01 9.209317e-01 19 45040312 45040747 436 + 0.797 0.938 0.543
ENSG00000104859 E015 137.8137851 0.0004175672 3.045887e-02 1.287169e-01 19 45052071 45052097 27 + 2.165 2.100 -0.218
ENSG00000104859 E016 181.5194058 0.0039243690 1.629146e-01 3.811090e-01 19 45052098 45052168 71 + 2.279 2.220 -0.196
ENSG00000104859 E017 122.1948042 0.0019620030 1.420663e-01 3.505252e-01 19 45052791 45052799 9 + 2.106 2.051 -0.185
ENSG00000104859 E018 236.4192400 0.0015883245 2.177664e-03 1.825718e-02 19 45052800 45052892 93 + 2.413 2.322 -0.301
ENSG00000104859 E019 25.9694532 0.0444737044 9.595790e-03 5.637730e-02 19 45052893 45053097 205 + 1.577 1.288 -0.998
ENSG00000104859 E020 133.1981891 0.0037525078 1.440414e-02 7.590513e-02 19 45053098 45053110 13 + 2.174 2.071 -0.346
ENSG00000104859 E021 258.6465395 0.0011384540 6.874886e-04 7.335011e-03 19 45053111 45053177 67 + 2.452 2.362 -0.299
ENSG00000104859 E022 294.3327677 0.0002463042 1.093898e-06 3.069547e-05 19 45056450 45056534 85 + 2.515 2.413 -0.338
ENSG00000104859 E023 375.9962896 0.0001750207 6.730218e-02 2.190391e-01 19 45057750 45057882 133 + 2.579 2.547 -0.104
ENSG00000104859 E024 154.0792339 0.0003027287 5.526249e-03 3.735295e-02 19 45057883 45057898 16 + 2.113 2.202 0.298
ENSG00000104859 E025 5.7387488 0.2996374954 2.433609e-01 4.804273e-01 19 45057899 45058253 355 + 0.906 0.748 -0.614
ENSG00000104859 E026 315.5430683 0.0004765985 9.691888e-02 2.763335e-01 19 45059268 45059364 97 + 2.505 2.471 -0.111
ENSG00000104859 E027 288.3513277 0.0014645192 2.173362e-01 4.502323e-01 19 45060389 45060467 79 + 2.464 2.432 -0.108
ENSG00000104859 E028 242.3556365 0.0007423458 4.819497e-01 6.883631e-01 19 45060554 45060627 74 + 2.380 2.365 -0.052
ENSG00000104859 E029 145.6956307 0.0025992057 7.822453e-02 2.412437e-01 19 45062154 45062195 42 + 2.104 2.175 0.239
ENSG00000104859 E030 215.4042249 0.0009404420 4.963081e-07 1.537719e-05 19 45064012 45064227 216 + 2.215 2.366 0.502
ENSG00000104859 E031 40.2736517 0.0034693279 5.094419e-02 1.819108e-01 19 45064228 45064342 115 + 1.511 1.640 0.441
ENSG00000104859 E032 196.5898080 0.0053810452 9.762632e-11 6.933656e-09 19 45064343 45064630 288 + 2.064 2.361 0.991
ENSG00000104859 E033 145.1656095 0.0017085145 4.739081e-11 3.588074e-09 19 45067337 45067470 134 + 1.969 2.223 0.853
ENSG00000104859 E034 203.1969894 0.0043233901 1.940132e-04 2.609942e-03 19 45067471 45067594 124 + 2.185 2.340 0.517
ENSG00000104859 E035 154.7263456 0.0029081421 6.184017e-02 2.069676e-01 19 45068015 45068054 40 + 2.125 2.201 0.253
ENSG00000104859 E036 48.4668473 0.0009258821 9.793240e-02 2.781602e-01 19 45068055 45068058 4 + 1.727 1.645 -0.281
ENSG00000104859 E037 27.0189440 0.0457725780 6.285839e-02 2.091499e-01 19 45068059 45068120 62 + 1.549 1.341 -0.718
ENSG00000104859 E038 21.5418675 0.0650096106 1.089958e-01 2.974018e-01 19 45068121 45068180 60 + 1.444 1.258 -0.646
ENSG00000104859 E039 39.6783937 0.0754245899 6.882776e-02 2.224312e-01 19 45068202 45068419 218 + 1.712 1.505 -0.704
ENSG00000104859 E040 191.3416910 0.0059342874 2.037389e-01 4.342476e-01 19 45068420 45068480 61 + 2.227 2.282 0.183
ENSG00000104859 E041 173.3388536 0.0040362309 1.607191e-01 3.778473e-01 19 45069066 45069082 17 + 2.183 2.242 0.196
ENSG00000104859 E042 210.6084844 0.0004796562 3.790161e-02 1.493645e-01 19 45069083 45069124 42 + 2.269 2.328 0.199
ENSG00000104859 E043 14.9330805 0.0217832308 4.592619e-01 6.726512e-01 19 45069125 45069201 77 + 1.233 1.157 -0.268
ENSG00000104859 E044 198.4264988 0.0020714568 2.642545e-01 5.035000e-01 19 45069202 45069248 47 + 2.257 2.294 0.126
ENSG00000104859 E045 38.0327399 0.0491366898 4.862199e-02 1.764194e-01 19 45069646 45069838 193 + 1.695 1.486 -0.712
ENSG00000104859 E046 21.5617826 0.0730912834 6.285424e-02 2.091410e-01 19 45069839 45069943 105 + 1.469 1.236 -0.809
ENSG00000104859 E047 24.7786476 0.0459877720 1.291375e-01 3.304233e-01 19 45069944 45070021 78 + 1.488 1.325 -0.563
ENSG00000104859 E048 239.6556973 0.0025920066 5.490934e-01 7.356783e-01 19 45070022 45070104 83 + 2.350 2.368 0.061
ENSG00000104859 E049 156.5723015 0.0004197132 4.778048e-01 6.856473e-01 19 45070537 45070561 25 + 2.164 2.189 0.084
ENSG00000104859 E050 17.0602180 0.0083690668 9.761675e-01 9.898654e-01 19 45070562 45070802 241 + 1.235 1.236 0.004
ENSG00000104859 E051 135.6031811 0.0006384895 3.202840e-01 5.599786e-01 19 45070803 45070956 154 + 2.094 2.130 0.123