ENSG00000104723

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382020 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding protein_coding 46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 4.8679261 1.8673341 5.851062 0.2762056 0.62943816 1.642477 0.10588750 0.10796667 0.11036667 0.00240000 1.000000e+00 2.970105e-06 FALSE TRUE
ENST00000507400 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding processed_transcript 46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 7.1410942 1.2594860 10.370206 1.2594860 1.32619999 3.031519 0.14261667 0.07213333 0.19746667 0.12533333 2.750685e-01 2.970105e-06 FALSE FALSE
ENST00000511783 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding protein_coding 46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 6.6763314 1.8723228 12.204619 1.3232661 2.04821716 2.698023 0.14615417 0.10166667 0.22903333 0.12736667 6.812184e-01 2.970105e-06 TRUE TRUE
MSTRG.31195.10 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding   46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 19.3483121 7.7798780 19.425129 0.7314733 0.74263106 1.318994 0.40983750 0.45316667 0.36670000 -0.08646667 5.284418e-01 2.970105e-06 FALSE FALSE
MSTRG.31195.5 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding   46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 4.5421453 2.9208979 1.020162 0.6013159 0.02465169 -1.508472 0.10222083 0.17370000 0.01926667 -0.15443333 2.970105e-06 2.970105e-06 FALSE TRUE
MSTRG.31195.9 ENSG00000104723 HEK293_OSMI2_6hA HEK293_TMG_6hB TUSC3 protein_coding   46.60941 17.20073 52.94342 0.9460314 1.363971 1.621416 0.8826399 0.8175985 0.000000 0.5018233 0.00000000 -6.370859 0.02839167 0.05086667 0.00000000 -0.05086667 1.563419e-04 2.970105e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104723 E001 0.0000000       8 15417215 15417305 91 +      
ENSG00000104723 E002 0.0000000       8 15483386 15483483 98 +      
ENSG00000104723 E003 0.0000000       8 15540223 15540226 4 +      
ENSG00000104723 E004 0.0000000       8 15540227 15540232 6 +      
ENSG00000104723 E005 0.3641499 0.0305902595 5.509998e-01   8 15540233 15540234 2 + 0.085 0.171 1.167
ENSG00000104723 E006 4.1483606 0.0059204075 7.958825e-04 8.248957e-03 8 15540235 15540262 28 + 0.468 0.941 1.996
ENSG00000104723 E007 7.2704284 0.0046019263 5.080300e-04 5.753213e-03 8 15540263 15540278 16 + 0.707 1.117 1.560
ENSG00000104723 E008 8.5826421 0.0170704228 1.026059e-02 5.922785e-02 8 15540279 15540280 2 + 0.821 1.133 1.163
ENSG00000104723 E009 9.9686067 0.0106994843 2.304334e-04 3.006522e-03 8 15540281 15540282 2 + 0.834 1.241 1.495
ENSG00000104723 E010 111.1242935 0.0005200269 4.971633e-07 1.539846e-05 8 15540283 15540568 286 + 1.956 2.128 0.576
ENSG00000104723 E011 0.0000000       8 15561563 15561596 34 +      
ENSG00000104723 E012 0.0000000       8 15561597 15561618 22 +      
ENSG00000104723 E013 0.0000000       8 15561619 15561640 22 +      
ENSG00000104723 E014 0.6246688 0.0190841885 1.821387e-01   8 15561641 15561685 45 + 0.270 0.000 -12.759
ENSG00000104723 E015 0.3228314 0.4409216033 6.558504e-01   8 15562514 15562590 77 + 0.156 0.000 -10.637
ENSG00000104723 E016 0.4762370 0.0217681645 2.039027e-01   8 15623078 15623079 2 + 0.085 0.294 2.165
ENSG00000104723 E017 214.0772359 0.0002577535 7.652283e-01 8.757851e-01 8 15623080 15623249 170 + 2.303 2.292 -0.039
ENSG00000104723 E018 269.8474869 0.0002001454 1.430147e-01 3.519983e-01 8 15650697 15650814 118 + 2.411 2.373 -0.125
ENSG00000104723 E019 0.2027342 0.0345304536 2.139134e-01   8 15650815 15651017 203 + 0.000 0.171 11.642
ENSG00000104723 E020 316.4669626 0.0003206134 2.866738e-02 1.233844e-01 8 15659507 15659647 141 + 2.482 2.431 -0.171
ENSG00000104723 E021 321.1240143 0.0003030760 3.188866e-01 5.586199e-01 8 15662156 15662296 141 + 2.481 2.457 -0.082
ENSG00000104723 E022 155.6039789 0.0003276993 9.710290e-01 9.873558e-01 8 15673747 15673762 16 + 2.163 2.160 -0.009
ENSG00000104723 E023 250.0370108 0.0002108818 7.403846e-01 8.606458e-01 8 15673763 15673836 74 + 2.370 2.358 -0.039
ENSG00000104723 E024 214.0252563 0.0017641672 8.400814e-01 9.194534e-01 8 15730666 15730729 64 + 2.302 2.292 -0.032
ENSG00000104723 E025 0.1723744 0.0324433925 2.141211e-01   8 15733392 15733645 254 + 0.000 0.171 11.666
ENSG00000104723 E026 0.0000000       8 15743444 15743445 2 +      
ENSG00000104723 E027 0.7912460 0.0175412147 1.805573e-01   8 15743446 15743529 84 + 0.155 0.389 1.752
ENSG00000104723 E028 0.3150090 0.0269821290 5.498617e-01   8 15743530 15743537 8 + 0.085 0.171 1.167
ENSG00000104723 E029 221.3496590 0.0016697224 7.116165e-01 8.428512e-01 8 15743538 15743612 75 + 2.311 2.319 0.026
ENSG00000104723 E030 189.9148140 0.0002836304 2.463079e-01 4.839107e-01 8 15748375 15748465 91 + 2.239 2.266 0.092
ENSG00000104723 E031 1.1159304 0.4289257704 5.492142e-01   8 15748466 15748846 381 + 0.364 0.167 -1.481
ENSG00000104723 E032 38.8104465 0.0019572391 1.950574e-02 9.421282e-02 8 15757791 15757855 65 + 1.515 1.653 0.472
ENSG00000104723 E033 0.6709767 0.0317477707 8.146743e-01   8 15757856 15757859 4 + 0.217 0.171 -0.421
ENSG00000104723 E034 6.4174217 0.0131031184 8.395526e-03 5.113893e-02 8 15758030 15758033 4 + 0.708 1.046 1.302
ENSG00000104723 E035 12.8544579 0.0028346997 7.131720e-02 2.274057e-01 8 15758034 15758278 245 + 1.046 1.217 0.612
ENSG00000104723 E036 284.7748923 0.0032014178 3.184122e-02 1.327255e-01 8 15764203 15766649 2447 + 2.444 2.370 -0.246
ENSG00000104723 E037 0.6081007 0.0216772777 1.831135e-01   8 15806363 15806415 53 + 0.270 0.000 -12.741