ENSG00000104691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265616 ENSG00000104691 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN8 protein_coding protein_coding 10.57247 2.770024 14.23773 0.05692785 0.8175721 2.357562 8.3285844 1.5809761 12.1196792 0.08092098 1.25093327 2.9305573 0.73848750 0.57006667 0.846666667 0.27660000 0.01425272 0.00398831 FALSE TRUE
ENST00000380154 ENSG00000104691 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN8 protein_coding nonsense_mediated_decay 10.57247 2.770024 14.23773 0.05692785 0.8175721 2.357562 0.5737788 0.2595377 0.5570843 0.08307040 0.17850537 1.0730761 0.06689167 0.09380000 0.040733333 -0.05306667 0.52273294 0.00398831 FALSE TRUE
ENST00000620074 ENSG00000104691 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN8 protein_coding protein_coding 10.57247 2.770024 14.23773 0.05692785 0.8175721 2.357562 0.1383971 0.1581189 0.1195910 0.06677127 0.05281459 -0.3755167 0.02379167 0.05806667 0.008033333 -0.05003333 0.15498418 0.00398831 FALSE TRUE
ENST00000620706 ENSG00000104691 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN8 protein_coding processed_transcript 10.57247 2.770024 14.23773 0.05692785 0.8175721 2.357562 0.2496896 0.2613563 0.1211812 0.02117997 0.06806181 -1.0486274 0.04640000 0.09450000 0.008466667 -0.08603333 0.00398831 0.00398831   FALSE
MSTRG.31361.4 ENSG00000104691 HEK293_OSMI2_6hA HEK293_TMG_6hB UBXN8 protein_coding   10.57247 2.770024 14.23773 0.05692785 0.8175721 2.357562 0.5854675 0.2311889 0.6805919 0.18173952 0.32105779 1.5176697 0.05418750 0.08443333 0.050533333 -0.03390000 1.00000000 0.00398831 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104691 E001 0.1614157 0.0329754318 1.000000000   8 30729131 30729345 215 + 0.062 0.000 -7.125
ENSG00000104691 E002 0.1614157 0.0329754318 1.000000000   8 30731529 30732370 842 + 0.062 0.000 -8.807
ENSG00000104691 E003 0.0000000       8 30732619 30733215 597 +      
ENSG00000104691 E004 0.0000000       8 30733216 30733308 93 +      
ENSG00000104691 E005 0.0000000       8 30733847 30734324 478 +      
ENSG00000104691 E006 1.4568735 0.0127872959 0.782437668 0.88610525 8 30744157 30744163 7 + 0.318 0.372 0.328
ENSG00000104691 E007 6.0415871 0.0085030905 0.166564550 0.38596875 8 30744164 30744173 10 + 0.805 0.568 -0.993
ENSG00000104691 E008 10.0646750 0.0031692230 0.344990901 0.58256428 8 30744174 30744188 15 + 0.976 0.850 -0.477
ENSG00000104691 E009 13.7246633 0.0033721892 0.522647735 0.71678718 8 30744189 30744189 1 + 1.093 1.019 -0.269
ENSG00000104691 E010 35.4395692 0.0010464115 0.346045956 0.58360136 8 30744190 30744277 88 + 1.474 1.404 -0.242
ENSG00000104691 E011 1.7075083 0.0562985231 0.037785251 0.14905469 8 30744278 30744327 50 + 0.249 0.643 2.133
ENSG00000104691 E012 3.9144970 0.0069224934 0.090659252 0.26499791 8 30744328 30744460 133 + 0.540 0.807 1.135
ENSG00000104691 E013 25.0470416 0.0017534358 0.255271472 0.49388416 8 30751396 30751396 1 + 1.338 1.236 -0.357
ENSG00000104691 E014 53.8575071 0.0007488420 0.351255691 0.58841138 8 30751397 30751506 110 + 1.646 1.590 -0.191
ENSG00000104691 E015 27.7288527 0.0015708803 0.976736277 0.99011678 8 30751507 30751518 12 + 1.353 1.355 0.008
ENSG00000104691 E016 24.3408938 0.0026817516 0.843468802 0.92134382 8 30753035 30753037 3 + 1.303 1.285 -0.061
ENSG00000104691 E017 47.5684280 0.0097604602 0.927944544 0.96600484 8 30753038 30753105 68 + 1.576 1.586 0.033
ENSG00000104691 E018 51.3273336 0.0033084534 0.604690903 0.77330037 8 30754665 30754749 85 + 1.617 1.583 -0.114
ENSG00000104691 E019 41.0985757 0.0009229858 0.817553265 0.90667475 8 30754750 30754787 38 + 1.523 1.507 -0.054
ENSG00000104691 E020 3.1641216 0.0128276659 0.001229773 0.01164968 8 30756119 30756283 165 + 0.378 0.891 2.289
ENSG00000104691 E021 73.8511879 0.0005216145 0.154732231 0.36901363 8 30756765 30756887 123 + 1.756 1.823 0.228
ENSG00000104691 E022 42.1228665 0.0010809032 0.216981443 0.44985398 8 30760888 30760929 42 + 1.519 1.597 0.268
ENSG00000104691 E023 0.0000000       8 30763146 30763272 127 +      
ENSG00000104691 E024 48.6593467 0.0008509106 0.712749708 0.84345807 8 30763273 30763347 75 + 1.590 1.612 0.075
ENSG00000104691 E025 129.5543688 0.0026907911 0.715282778 0.84511705 8 30766227 30767006 780 + 2.016 2.001 -0.051