ENSG00000104613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397977 ENSG00000104613 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS10 protein_coding protein_coding 27.59663 11.78374 43.41883 0.7089818 1.935079 1.880632 19.487648 8.6882725 29.393012 1.4791811 0.1991761 1.757163 0.69732083 0.72716667 0.67986667 -0.0473 8.871673e-01 4.453589e-06 FALSE  
ENST00000517546 ENSG00000104613 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS10 protein_coding retained_intron 27.59663 11.78374 43.41883 0.7089818 1.935079 1.880632 1.322639 0.6414994 1.611254 0.1839352 0.2578685 1.315274 0.05438333 0.05666667 0.03676667 -0.0199 7.995932e-01 4.453589e-06    
MSTRG.31229.4 ENSG00000104613 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS10 protein_coding   27.59663 11.78374 43.41883 0.7089818 1.935079 1.880632 1.776910 0.0000000 3.857709 0.0000000 1.2410428 8.595336 0.05450417 0.00000000 0.08710000 0.0871 4.453589e-06 4.453589e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104613 E001 5.2269395 0.0056470210 0.25740683 0.49614227 8 19817202 19817390 189 + 0.693 0.853 0.642
ENSG00000104613 E002 3.8848594 0.0166456163 0.06810040 0.22080331 8 19817391 19817415 25 + 0.536 0.819 1.197
ENSG00000104613 E003 4.2596081 0.0636393400 0.16119995 0.37856899 8 19817416 19817431 16 + 0.584 0.822 0.993
ENSG00000104613 E004 4.6422493 0.0078268831 0.42592678 0.64794336 8 19817432 19817436 5 + 0.659 0.779 0.493
ENSG00000104613 E005 5.3815078 0.0215316231 0.15435616 0.36850767 8 19817437 19817438 2 + 0.677 0.887 0.837
ENSG00000104613 E006 10.2309879 0.0055812743 0.01322872 0.07136632 8 19817439 19817449 11 + 0.899 1.174 1.006
ENSG00000104613 E007 49.4188067 0.0008765766 0.04764093 0.17414711 8 19817450 19817580 131 + 1.615 1.726 0.378
ENSG00000104613 E008 73.5032920 0.0014484063 0.78102377 0.88529512 8 19817581 19817666 86 + 1.810 1.827 0.056
ENSG00000104613 E009 2.4458570 0.2245224150 0.24897799 0.48675188 8 19818194 19818274 81 + 0.401 0.689 1.356
ENSG00000104613 E010 80.7252252 0.0005781076 0.77393002 0.88109459 8 19818275 19818342 68 + 1.853 1.868 0.050
ENSG00000104613 E011 4.2537089 0.0067043131 0.29779289 0.53827049 8 19818343 19818473 131 + 0.621 0.779 0.654
ENSG00000104613 E012 4.7564472 0.0093669954 0.80748071 0.90066400 8 19818474 19818872 399 + 0.725 0.689 -0.148
ENSG00000104613 E013 118.1175320 0.0003548656 0.54727308 0.73432853 8 19819573 19819676 104 + 2.025 2.005 -0.069
ENSG00000104613 E014 151.3308136 0.0003752825 0.53144385 0.72303493 8 19820379 19820518 140 + 2.130 2.110 -0.064
ENSG00000104613 E015 3.4392106 0.0068133528 0.05612645 0.19391523 8 19820949 19822438 1490 + 0.676 0.325 -1.751
ENSG00000104613 E016 143.4427136 0.0004173154 0.37877908 0.61122481 8 19822439 19822520 82 + 2.110 2.081 -0.096
ENSG00000104613 E017 135.9506426 0.0003613669 0.51564344 0.71204101 8 19823301 19823387 87 + 2.073 2.097 0.081
ENSG00000104613 E018 123.0015809 0.0003647588 0.36935295 0.60355086 8 19823388 19823441 54 + 2.028 2.063 0.115
ENSG00000104613 E019 0.1614157 0.0331958861 1.00000000   8 19823442 19823452 11 + 0.075 0.000 -7.847
ENSG00000104613 E020 107.5944327 0.0004400587 0.78031180 0.88496064 8 19823873 19823894 22 + 1.977 1.990 0.042
ENSG00000104613 E021 164.0134489 0.0003013374 0.21990721 0.45339369 8 19823895 19823981 87 + 2.171 2.134 -0.124
ENSG00000104613 E022 135.7762587 0.0004257323 0.05328410 0.18740219 8 19823982 19824044 63 + 2.097 2.030 -0.224
ENSG00000104613 E023 7.4588977 0.0364293711 0.46252097 0.67483609 8 19824045 19824492 448 + 0.900 0.780 -0.467
ENSG00000104613 E024 5.9885948 0.0662173651 0.55757631 0.74153855 8 19824664 19824802 139 + 0.812 0.693 -0.479
ENSG00000104613 E025 100.3890306 0.0015330374 0.01542590 0.07969798 8 19824803 19824837 35 + 1.976 1.868 -0.363
ENSG00000104613 E026 159.4828792 0.0003419649 0.28148324 0.52180251 8 19824838 19824972 135 + 2.156 2.123 -0.111
ENSG00000104613 E027 197.4978006 0.0011656172 0.99742901 1.00000000 8 19826426 19826559 134 + 2.239 2.239 0.001
ENSG00000104613 E028 9.4051413 0.0536244730 0.02772459 0.12048796 8 19830403 19830405 3 + 1.035 0.642 -1.540
ENSG00000104613 E029 164.8329342 0.0032468258 0.92235887 0.96345623 8 19830406 19830518 113 + 2.161 2.165 0.012
ENSG00000104613 E030 78.8630784 0.0005421834 0.57160219 0.75140648 8 19830519 19830559 41 + 1.851 1.827 -0.081
ENSG00000104613 E031 124.6420170 0.0004229815 0.32490131 0.56411347 8 19832028 19832100 73 + 2.031 2.069 0.126
ENSG00000104613 E032 89.0878671 0.0005885577 0.06084280 0.20468921 8 19832101 19832110 10 + 1.873 1.954 0.272
ENSG00000104613 E033 182.0052076 0.0003015551 0.93741860 0.97090396 8 19833169 19833321 153 + 2.205 2.204 -0.001
ENSG00000104613 E034 67.6301590 0.0005582068 0.16055832 0.37762592 8 19837052 19837052 1 + 1.795 1.727 -0.231
ENSG00000104613 E035 95.6795159 0.0004460320 0.10704353 0.29404029 8 19837053 19837080 28 + 1.944 1.878 -0.223
ENSG00000104613 E036 146.1562696 0.0002727843 0.33001775 0.56895995 8 19837081 19837160 80 + 2.118 2.087 -0.103
ENSG00000104613 E037 1.5962992 0.0556381773 0.73454063 0.85700611 8 19837161 19837517 357 + 0.397 0.326 -0.421
ENSG00000104613 E038 2.9791435 0.0380488380 0.33441072 0.57298872 8 19841827 19841955 129 + 0.513 0.686 0.773
ENSG00000104613 E039 127.5434031 0.0003205981 0.52511362 0.71851529 8 19842848 19842898 51 + 2.058 2.037 -0.070
ENSG00000104613 E040 104.2861039 0.0003862992 0.67221466 0.81770621 8 19842899 19842927 29 + 1.969 1.954 -0.049
ENSG00000104613 E041 79.6043827 0.0005617397 0.26166725 0.50072804 8 19844076 19844080 5 + 1.859 1.809 -0.169
ENSG00000104613 E042 119.9702806 0.0003427767 0.83294298 0.91545688 8 19844081 19844127 47 + 2.025 2.019 -0.021
ENSG00000104613 E043 161.9360146 0.0002919297 0.31411599 0.55434308 8 19844128 19844238 111 + 2.144 2.178 0.112
ENSG00000104613 E044 8.5391820 0.1341779307 0.46171314 0.67432023 8 19845423 19845696 274 + 0.882 1.025 0.535
ENSG00000104613 E045 3.5102459 0.0604711755 0.18091188 0.40517206 8 19845697 19845703 7 + 0.537 0.776 1.023
ENSG00000104613 E046 141.2790865 0.0043549019 0.09117689 0.26583481 8 19845704 19845797 94 + 2.074 2.148 0.247
ENSG00000104613 E047 6.6345335 0.0096030387 0.22264779 0.45664426 8 19845798 19845914 117 + 0.782 0.944 0.625
ENSG00000104613 E048 13.2315186 0.0155536718 0.08395178 0.25268542 8 19848763 19849161 399 + 1.045 1.234 0.677
ENSG00000104613 E049 7.2699504 0.0342032206 0.00932684 0.05520781 8 19849162 19849239 78 + 0.740 1.103 1.375
ENSG00000104613 E050 253.5414411 0.0010319499 0.23335220 0.46899193 8 19851649 19852083 435 + 2.337 2.371 0.112