ENSG00000104517

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220959 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding protein_coding 20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 2.633864 1.5814515 6.300743 0.3826624 0.2483974 1.9874667 0.11650833 0.09913333 0.22560000 0.1264667 3.878705e-05 7.715214e-17 FALSE TRUE
ENST00000517465 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding retained_intron 20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 3.620050 3.9314966 2.276936 1.2835466 0.2164773 -0.7853276 0.18715000 0.23130000 0.08180000 -0.1495000 2.194580e-06 7.715214e-17 TRUE TRUE
ENST00000518205 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding protein_coding 20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 4.321355 5.6391378 3.224764 1.9984119 0.5052080 -0.8043702 0.21990417 0.31850000 0.11510000 -0.2034000 1.394524e-03 7.715214e-17 FALSE TRUE
ENST00000520539 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding protein_coding 20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 4.383060 3.5861239 5.469948 1.1597799 0.2173952 0.6077194 0.21341667 0.20793333 0.19613333 -0.0118000 9.349805e-01 7.715214e-17 FALSE TRUE
MSTRG.31937.3 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding   20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 1.122545 0.3846088 1.477391 0.1923221 0.1436003 1.9142891 0.05484583 0.03643333 0.05283333 0.0164000 8.007625e-01 7.715214e-17 FALSE TRUE
MSTRG.31937.5 ENSG00000104517 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR5 protein_coding   20.68175 16.74823 27.91942 5.036909 0.4326238 0.7369153 2.774665 0.6480787 6.953055 0.1383763 0.2463381 3.4033884 0.12145417 0.04170000 0.24890000 0.2072000 7.715214e-17 7.715214e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000104517 E001 109.7445235 1.3341477790 3.438040e-01 5.814569e-01 8 102252273 102253735 1463 - 1.849 2.239 1.305
ENSG00000104517 E002 97.3694416 0.0195329818 5.130564e-04 5.795834e-03 8 102253736 102253945 210 - 1.841 2.143 1.014
ENSG00000104517 E003 187.3647303 0.0010562047 3.225247e-18 7.586164e-16 8 102253946 102254197 252 - 2.127 2.414 0.962
ENSG00000104517 E004 159.2456395 0.0031642616 3.464279e-13 3.883262e-11 8 102254198 102254350 153 - 2.044 2.357 1.049
ENSG00000104517 E005 183.4622307 0.0206297834 8.424860e-05 1.295940e-03 8 102254351 102254514 164 - 2.109 2.423 1.050
ENSG00000104517 E006 120.2046408 1.3793030645 3.816461e-01 6.136327e-01 8 102257632 102257717 86 - 1.904 2.264 1.205
ENSG00000104517 E007 5.6374151 0.0057755858 6.055396e-01 7.738670e-01 8 102258316 102258424 109 - 0.774 0.862 0.347
ENSG00000104517 E008 171.7844164 0.0332085356 1.530324e-02 7.921692e-02 8 102258985 102259129 145 - 2.102 2.370 0.895
ENSG00000104517 E009 158.2715116 0.0003395755 1.079324e-09 6.260043e-08 8 102261146 102261259 114 - 2.094 2.300 0.687
ENSG00000104517 E010 178.5438573 0.0006628355 1.686816e-08 7.524565e-07 8 102261915 102262070 156 - 2.149 2.341 0.643
ENSG00000104517 E011 115.3659458 0.0007043544 1.690474e-07 5.944944e-06 8 102264474 102264558 85 - 1.951 2.161 0.704
ENSG00000104517 E012 152.0285327 0.0019025728 3.369440e-05 5.958643e-04 8 102265100 102265202 103 - 2.086 2.261 0.587
ENSG00000104517 E013 90.3252695 0.0021779151 1.553580e-02 8.010738e-02 8 102265203 102265207 5 - 1.880 2.014 0.449
ENSG00000104517 E014 124.9864232 0.0065229705 3.825593e-02 1.502622e-01 8 102265208 102265275 68 - 2.019 2.156 0.457
ENSG00000104517 E015 59.0858333 0.0017357155 8.910867e-02 2.621305e-01 8 102265276 102265278 3 - 1.708 1.819 0.376
ENSG00000104517 E016 124.8043627 0.0007105897 2.491709e-02 1.119621e-01 8 102266947 102267007 61 - 2.029 2.134 0.350
ENSG00000104517 E017 8.6859899 0.0264040542 4.076219e-01 6.342058e-01 8 102267008 102267092 85 - 0.992 0.889 -0.387
ENSG00000104517 E018 59.2724970 0.1663200033 4.580829e-01 6.717912e-01 8 102267093 102268977 1885 - 1.783 1.659 -0.420
ENSG00000104517 E019 160.6616569 0.0003556585 2.142467e-02 1.007254e-01 8 102268978 102269108 131 - 2.142 2.237 0.315
ENSG00000104517 E020 168.3229257 0.0006881776 2.033657e-04 2.712145e-03 8 102270039 102270183 145 - 2.144 2.283 0.464
ENSG00000104517 E021 125.8332529 0.0003556383 2.739910e-05 4.984999e-04 8 102271134 102271193 60 - 2.010 2.174 0.549
ENSG00000104517 E022 131.4425340 0.0003249841 1.561217e-02 8.040561e-02 8 102271194 102271245 52 - 2.054 2.158 0.348
ENSG00000104517 E023 238.0207077 0.0011998763 2.683562e-04 3.410421e-03 8 102272529 102272772 244 - 2.300 2.428 0.427
ENSG00000104517 E024 0.6238610 0.0193874923 4.580239e-01   8 102272773 102272931 159 - 0.155 0.294 1.170
ENSG00000104517 E025 129.2888077 0.0012250874 7.391027e-04 7.773853e-03 8 102275521 102275619 99 - 2.027 2.173 0.487
ENSG00000104517 E026 127.0617399 0.0019932669 7.368942e-05 1.159363e-03 8 102275708 102275828 121 - 2.009 2.184 0.587
ENSG00000104517 E027 0.8323924 0.0176543129 5.696535e-01   8 102276774 102276971 198 - 0.270 0.172 -0.829
ENSG00000104517 E028 161.1553877 0.0002983904 1.529162e-05 3.031954e-04 8 102276972 102277192 221 - 2.122 2.274 0.508
ENSG00000104517 E029 137.3760454 0.0018717090 3.518432e-02 1.420615e-01 8 102278826 102278939 114 - 2.069 2.174 0.353
ENSG00000104517 E030 176.5222005 0.0042259000 2.409281e-01 4.776289e-01 8 102279036 102279208 173 - 2.190 2.264 0.247
ENSG00000104517 E031 138.4303735 0.0066330604 8.289768e-01 9.132560e-01 8 102280394 102280467 74 - 2.100 2.132 0.109
ENSG00000104517 E032 197.4044286 0.0007951821 4.380341e-01 6.572411e-01 8 102281289 102281519 231 - 2.262 2.264 0.007
ENSG00000104517 E033 112.9966241 0.0004519494 4.908602e-01 6.945617e-01 8 102285127 102285244 118 - 2.022 2.022 -0.002
ENSG00000104517 E034 85.1980135 0.0009590922 8.506922e-01 9.254186e-01 8 102285245 102285338 94 - 1.897 1.913 0.056
ENSG00000104517 E035 137.3561728 0.0028357132 5.943506e-01 7.665652e-01 8 102285513 102285781 269 - 2.108 2.110 0.008
ENSG00000104517 E036 134.0567920 0.0006442464 1.080063e-01 2.957235e-01 8 102286360 102286617 258 - 2.070 2.149 0.263
ENSG00000104517 E037 72.4924795 0.0005709342 8.319055e-02 2.511630e-01 8 102287433 102287504 72 - 1.799 1.900 0.341
ENSG00000104517 E038 88.4912639 0.0010738298 6.682717e-01 8.150818e-01 8 102287505 102287564 60 - 1.901 1.943 0.143
ENSG00000104517 E039 121.3975809 0.0005420582 4.066980e-01 6.335635e-01 8 102288155 102288266 112 - 2.055 2.050 -0.015
ENSG00000104517 E040 110.1879057 0.0003688900 2.097028e-01 4.415230e-01 8 102289453 102289528 76 - 2.018 1.997 -0.070
ENSG00000104517 E041 103.0050119 0.0003978897 2.185675e-02 1.020898e-01 8 102289529 102289576 48 - 2.003 1.940 -0.212
ENSG00000104517 E042 165.3259369 0.0009214392 3.630071e-03 2.709756e-02 8 102293605 102293844 240 - 2.209 2.138 -0.238
ENSG00000104517 E043 102.5545071 0.0036104488 2.075698e-02 9.852734e-02 8 102293955 102294115 161 - 2.007 1.921 -0.289
ENSG00000104517 E044 87.4508308 0.0004873075 3.974214e-02 1.540651e-01 8 102294982 102295111 130 - 1.931 1.870 -0.206
ENSG00000104517 E045 94.9437517 0.0015246621 5.036918e-03 3.483403e-02 8 102295204 102295330 127 - 1.981 1.883 -0.331
ENSG00000104517 E046 92.0778682 0.0007105090 5.937195e-04 6.524278e-03 8 102295414 102295532 119 - 1.972 1.852 -0.404
ENSG00000104517 E047 103.4422715 0.0006552467 1.643153e-05 3.231442e-04 8 102295636 102295782 147 - 2.030 1.881 -0.501
ENSG00000104517 E048 92.1168630 0.0004398547 3.587787e-06 8.658360e-05 8 102296893 102296984 92 - 1.983 1.812 -0.576
ENSG00000104517 E049 103.9196290 0.0047769216 2.527036e-04 3.249158e-03 8 102297458 102297606 149 - 2.036 1.875 -0.544
ENSG00000104517 E050 78.1765308 0.0033360124 2.502413e-05 4.617719e-04 8 102298392 102298489 98 - 1.921 1.722 -0.672
ENSG00000104517 E051 46.9399647 0.0033099782 7.287791e-04 7.685261e-03 8 102298848 102298859 12 - 1.698 1.505 -0.657
ENSG00000104517 E052 49.7309187 0.0048186514 1.939181e-04 2.608869e-03 8 102298860 102298866 7 - 1.729 1.505 -0.765
ENSG00000104517 E053 79.9670380 0.0077222304 4.766550e-04 5.465697e-03 8 102298867 102298971 105 - 1.930 1.731 -0.670
ENSG00000104517 E054 51.7911754 0.0181244649 8.368106e-03 5.101583e-02 8 102299452 102299496 45 - 1.746 1.542 -0.692
ENSG00000104517 E055 50.6994650 0.0163311044 1.404124e-01 3.481567e-01 8 102299497 102299547 51 - 1.708 1.623 -0.287
ENSG00000104517 E056 82.3381741 0.0005505387 1.799083e-03 1.569466e-02 8 102300000 102300151 152 - 1.921 1.809 -0.378
ENSG00000104517 E057 6.6725571 0.1904928368 6.588264e-01 8.092749e-01 8 102302271 102302481 211 - 0.887 0.793 -0.364
ENSG00000104517 E058 78.2211364 0.0016233228 3.131086e-06 7.709590e-05 8 102304043 102304166 124 - 1.923 1.718 -0.693
ENSG00000104517 E059 42.2857093 0.0011819578 1.209870e-05 2.472512e-04 8 102304167 102304169 3 - 1.672 1.417 -0.871
ENSG00000104517 E060 120.1931635 0.0005168217 4.582244e-08 1.844006e-06 8 102305085 102305295 211 - 2.100 1.918 -0.611
ENSG00000104517 E061 112.5772653 0.0004268378 5.730656e-06 1.298289e-04 8 102311299 102311496 198 - 2.064 1.915 -0.498
ENSG00000104517 E062 84.6964647 0.0005978992 4.738142e-07 1.477227e-05 8 102311735 102311889 155 - 1.954 1.753 -0.678
ENSG00000104517 E063 67.1132945 0.0005683569 1.354254e-05 2.727509e-04 8 102312134 102312245 112 - 1.853 1.663 -0.643
ENSG00000104517 E064 71.2581747 0.0006877776 5.919261e-08 2.321004e-06 8 102312342 102312485 144 - 1.888 1.644 -0.825
ENSG00000104517 E065 89.3943538 0.0004298505 1.926600e-10 1.285078e-08 8 102313804 102313916 113 - 1.987 1.731 -0.864
ENSG00000104517 E066 84.3457059 0.0005214546 5.186548e-11 3.890438e-09 8 102314744 102314853 110 - 1.967 1.690 -0.937
ENSG00000104517 E067 98.6904028 0.0004685677 3.399185e-14 4.596018e-12 8 102323311 102323495 185 - 2.040 1.738 -1.017
ENSG00000104517 E068 81.2198454 0.0010675280 6.593318e-09 3.214749e-07 8 102326546 102326663 118 - 1.945 1.690 -0.862
ENSG00000104517 E069 91.2160415 0.0008685125 2.630145e-06 6.619132e-05 8 102327742 102327896 155 - 1.979 1.796 -0.616
ENSG00000104517 E070 71.9766511 0.0048966486 1.061171e-04 1.572386e-03 8 102329090 102329200 111 - 1.884 1.676 -0.702
ENSG00000104517 E071 84.2996968 0.0005810082 9.779481e-10 5.720912e-08 8 102329283 102329399 117 - 1.962 1.706 -0.863
ENSG00000104517 E072 114.5857842 0.0017317239 3.016198e-15 4.751575e-13 8 102342473 102342666 194 - 2.108 1.778 -1.110
ENSG00000104517 E073 26.8200533 0.0014896719 1.501204e-04 2.099818e-03 8 102342667 102342684 18 - 1.481 1.204 -0.963
ENSG00000104517 E074 100.1392505 0.0004654587 1.447106e-10 9.929367e-09 8 102345396 102345545 150 - 2.037 1.795 -0.813
ENSG00000104517 E075 0.0000000       8 102345896 102346235 340 -      
ENSG00000104517 E076 92.1057643 0.0088324058 1.088316e-04 1.604072e-03 8 102346236 102346395 160 - 1.996 1.783 -0.719
ENSG00000104517 E077 79.7486074 0.0069345191 1.845032e-05 3.568259e-04 8 102346903 102347092 190 - 1.940 1.698 -0.817
ENSG00000104517 E078 0.1723744 0.1026690911 2.257817e-01   8 102359652 102360070 419 - 0.000 0.172 10.224
ENSG00000104517 E079 58.8486954 0.0069803679 1.217080e-05 2.485726e-04 8 102360071 102360190 120 - 1.816 1.540 -0.935
ENSG00000104517 E080 46.3929038 0.0181349167 1.549692e-03 1.395923e-02 8 102360589 102360665 77 - 1.714 1.444 -0.922
ENSG00000104517 E081 47.9681450 0.0452829033 1.206883e-02 6.672370e-02 8 102361125 102361206 82 - 1.731 1.448 -0.965
ENSG00000104517 E082 0.3088520 0.0264484821 5.795414e-01   8 102361207 102361209 3 - 0.085 0.171 1.167
ENSG00000104517 E083 31.7396045 0.0029977564 9.569881e-05 1.440895e-03 8 102361582 102361626 45 - 1.557 1.286 -0.934
ENSG00000104517 E084 42.7163328 0.0430605213 1.783109e-01 4.016307e-01 8 102412173 102412759 587 - 1.654 1.498 -0.535